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  • 柠檬烯;双戊烯

    Limonene

    柠檬烯;双戊烯
    产品编号 CFN93050
    CAS编号 138-86-3
    分子式 = 分子量 C10H16 = 136.2
    产品纯度 >=98%
    物理属性 Oil
    化合物类型 Monoterpenoids
    植物来源 The peels of Citrus limon.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    柠檬烯;双戊烯 CFN93050 138-86-3 10mg QQ客服:215959384
    柠檬烯;双戊烯 CFN93050 138-86-3 20mg QQ客服:215959384
    柠檬烯;双戊烯 CFN93050 138-86-3 50mg QQ客服:215959384
    柠檬烯;双戊烯 CFN93050 138-86-3 100mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Mendel University in Brno (Czech Republic)
  • Regional Crop Research Institute (Korea)
  • University of Helsinki (Finland)
  • Shanghai Institute of Organic Chemistry (China)
  • Martin Luther University of Halle-Wittenberg (Germany)
  • Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
  • Macau University of Science and Technology (China)
  • National Cancer Institute (USA)
  • University of Malaya (Malaysia)
  • Chinese University of Hong Kong (China)
  • University of Hawaii Cancer Center (USA)
  • Wroclaw Medical University (Poland)
  • Johannes Gutenberg University Mainz (JGU) (Germany)
  • Monash University (Australia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Front Pharmacol.2019, 10:1025
  • Journal of Ginseng Research2019, 10.1016
  • Enzyme Microb Technol.2022, 161:110111.
  • Appl Microbiol Biotechnol.2018, 102(12):5105-5120
  • J Sep Sci.2018, 41(7):1682-1690
  • Metabolites.2023, 13(5):625.
  • Cardiovasc Toxicol.2019, 19(4):297-305
  • ARPN Journal of Eng.& Applied Sci.2016, 2199-2204
  • Nat Prod Sci.2014, 20(3):182-190
  • Molecules.2017, 22(6)
  • Tumour Biol.2015, 36(9):7027-34
  • Univerzita Karlova2022, 228192.
  • Korean j.of Pharm.2017, 70-76
  • Molecules.2019, 24(2):329
  • Molecules.2023, 28(3):958.
  • Eur J Pharm Sci.2016, 94:33-45
  • Evid Based Complement Alternat Med.2021, 8707280.
  • The Journal of Korean Medicine2022, 43(3): 79-93.
  • Plant Physiol Biochem.2019, 144:355-364
  • Int J Mol Sci.2020, 21(22):8816.
  • Pharmaceutics.2022, 14(12):2765.
  • Int J Mol Sci.2023, 24(17):13230.
  • Sci Rep.2019, 9(1):4646
  • ...
  • 生物活性
    Description: Limonene has antioxidant activity, it at all concentrations reveal a reduction in the frequency of MN and DNA damage induced by H2O2.
    Targets: P450 (e.g. CYP17)
    In vitro:
    Food Chem Toxicol. 2015 Jul;81:160-70.
    The antioxidant and antigenotoxic properties of citrus phenolics limonene and naringin.[Pubmed: 25896273]
    Phenolic compounds not only contribute to the sensory qualities of fruits and vegetables but also exhibit several health protective properties. Limonene and naringin are the most popular phenolics found in Citrus plants.
    METHODS AND RESULTS:
    In this study, we investigated the antioxidant capacities of limonene and naringin by the trolox equivalent antioxidant capacity (TEAC) assay and the cytotoxic effects by 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay in Chinese hamster fibroblast (V79) cells. The genotoxic potentials of limonene and naringin were evaluated by micronucleus (MN) and alkaline COMET assays in human lymphocytes and V79 cells. Limonene and naringin, were found to have antioxidant activities at concentrations of 2-2000 µM and 5-2000 µM respectively. IC50 values of limonene and naringin were found to be 1265 µM and 9026 µM, respectively. Limonene at the concentrations below 10,000 µM and naringin at the all concentrations studied, have not exerted genotoxic effects in lymphocytes and in V79 cells.
    CONCLUSIONS:
    Limonene and naringin at all concentrations revealed a reduction in the frequency of MN and DNA damage induced by H2O2.
    Phytomedicine . 2019 Feb;53:37-42.
    Gastroprotective effect of limonene in rats: Influence on oxidative stress, inflammation and gene expression[Pubmed: 30668410]
    Abstract Background: In an increasing search for natural products that may heal the ulcers and avoid its recurrence, limonene appears as a promising candidate. Hypothesis/purpose: The present study aimed to investigate the protective effect of limonene in ethanol-induced gastric ulcers, in addition, to investigate the involvement of antioxidant and anti-inflammatory activities, besides the modulation of gene expression. Study design: Male Wistar rats were orally treated with vehicle (8% tween 80), carbenoxolone (100 mg/kg) or limonene (25, 50 or 100 mg/kg) and then orally received ethanol to induce gastric ulcers formation. Methods: The activity of myeloperoxidase (MPO) was measured. Levels of glutathione (GSH) and activities of glutathione peroxidase (GPx), glutathione reductase (GR) and superoxide dismutase (SOD) were measured. We investigated the anti-inflammatory effect of limonene measuring the levels of pro-inflammatory cytokines tumor necrosis factor-a (TNF-a), interleukin-6 (IL-6), interleukin-1β (IL-1β) and anti-inflammatory cytokine interleukin-10 (IL-10) by ELISA. Additionally, we investigate through real-time PCR (qPCR) the gene expression of nuclear factor-kappa B (Nf-κb), Gpx, Il-1β, Mpo, and Il-10. Results: Our results showed that limonene 50 mg/kg was the lowest effective dose, offering 93% of reduction in gastric ulcer area compared with the vehicle. There was an increase in mucus production and higher preservation of gastric mucosa integrity after treatment with limonene.There was a reduction in the MPO activity, a biomarker of neutrophils infiltration, and an increase in GPx activity, suggesting an antioxidant effect. Limonene displayed anti-inflammatory activity through decreasing the levels of TNF-a, IL-6, and IL-1β and increasing the level of IL-10. Limonene could down-regulate the expression of Nf-κb, Il-1β, and Mpo and up-regulate the expression of Gpx. Conclusion: Our results demonstrate that oral treatment with limonene exerts gastroprotection through local mucosal defense mechanisms, such as increasing the mucus production, modulation of the oxidative stress and inflammatory response and inhibition of Nf-κb expression. Keywords: Antioxidant; Gastric ulcer; Gene expression; Inflammation; Limonene; qPCR.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 7.3421 mL 36.7107 mL 73.4214 mL 146.8429 mL 183.5536 mL
    5 mM 1.4684 mL 7.3421 mL 14.6843 mL 29.3686 mL 36.7107 mL
    10 mM 0.7342 mL 3.6711 mL 7.3421 mL 14.6843 mL 18.3554 mL
    50 mM 0.1468 mL 0.7342 mL 1.4684 mL 2.9369 mL 3.6711 mL
    100 mM 0.0734 mL 0.3671 mL 0.7342 mL 1.4684 mL 1.8355 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    薄荷酮; Menthone CFN93280 10458-14-7 C10H18O = 154.3 20mg QQ客服:3257982914
    蒲勒酮, 胡薄荷酮,长叶薄荷酮; Pulegone CFN93286 89-82-7 C10H16O = 152.2 20mg QQ客服:2159513211
    异长叶薄荷酮; (-)Isopulegone CFN91649 17882-43-8 C10H16O = 152.23 5mg QQ客服:1457312923
    异胡薄荷醇; Isopulegol CFN98126 7786-67-6 C10H18O = 154.25 20mg QQ客服:2159513211
    D-薄荷醇; D-Menthol CFN98125 15356-60-2 C10H20O = 156.27 20mg QQ客服:2056216494
    氯甲酸薄荷酯; (1S)-(+)-Menthyl chloroformate CFN98124 7635-54-3 C11H19ClO2 = 218.72 20mg QQ客服:2056216494
    (+)-异胡薄荷醇; (+)-Isopulegol CFN98127 104870-56-6 C10H18O = 154.25 20mg QQ客服:2056216494
    DL-薄荷醇; DL-Menthol CFN99160 15356-70-4 C10H20O = 156.27 20mg QQ客服:2159513211
    对薄荷烯-3,6-二醇; p-Menth-1-ene-3,6-diol CFN98633 4031-55-4 C10H18O2 = 170.3 5mg QQ客服:1457312923
    Eucamalol; Eucamalol CFN99604 145544-91-8 C10H16O2 = 168.2 5mg QQ客服:2056216494

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