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  • 女贞甙

    Ligustroside

    女贞甙
    产品编号 CFN98484
    CAS编号 35897-92-8
    分子式 = 分子量 C25H32O12 = 524.5
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Iridoids
    植物来源 The seeds of Ligustrum lucidum
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    女贞甙 CFN98484 35897-92-8 1mg QQ客服:2159513211
    女贞甙 CFN98484 35897-92-8 5mg QQ客服:2159513211
    女贞甙 CFN98484 35897-92-8 10mg QQ客服:2159513211
    女贞甙 CFN98484 35897-92-8 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Monash University (Australia)
  • Weizmann Institute of Science (Israel)
  • Celltrion Chemical Research Institute (Korea)
  • Universitas islam negeri Jakarta (Indonesia)
  • Deutsches Krebsforschungszentrum (Germany)
  • Ain Shams University (Egypt)
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  • Subang Jaya Medical Centre (Malaysia)
  • Complutense University of Madrid (Spain)
  • Vin?a Institute of Nuclear Sciences (Serbia)
  • Chungnam National University (Korea)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Inflammation.2015, 38(4):1502-16
  • Academic J of Second Military Medical University2019, 40(1)
  • Drug Des Devel Ther.2020, 14:5189-5204.
  • Molecules.2019, 24(24):E4536
  • World J Mens Health.2019, 10.5534
  • J Nat Med.2022, 76(1):59-67.
  • Univerzita Karlova2022, 228192.
  • European Journal of Integrative Medicine2018, 20:165-172
  • Clin Transl Med.2021, 11(5):e392.
  • J Holistic Integrative Pharm.2023, 4(1):14-28
  • Nutr Res Pract.2020, 14(3):203-217.
  • J Cell Mol Med.2023, 27(11):1592-1602.
  • Food Science&Tech. Res.2022, 28(2):123-132.
  • Hum Exp Toxicol.2023, 42:9603271221145386.
  • J Nat Med.2018, 72(3):734-744
  • Preprints2022, 202211.0388.v1.
  • Plants (Basel).2021, 10(4):702.
  • Synthetic and Systems Biotechnology2023, j.synbio.
  • Acta Pharmaceutica Hungarica2016, 86:35-40
  • Phytomedicine.2019, 55:229-237
  • Food Bioscience2022, 50:102187.
  • JLiquid Chromatography & Related Tech.2021, 10826076.
  • Process Biochemistry2019, 85:106-115
  • ...
  • 生物活性
    Description: Ligustroside shows little antioxidant, and anti-inflammatory properties, it shows a significant inhibition effect on prostaglandin E2 (PGE2)-release. Ligustroside shows moderate antiviral activities against parainfluenza type 3 virus.
    Targets: EGFR | COX | LOX | PGE | Influenza virus
    In vitro:
    J Nat Med. 2011 Jan;65(1):237-40.
    Cytotoxic and EGFR tyrosine kinase inhibitory activities of aglycone derivatives obtained by enzymatic hydrolysis of oleoside-type secoiridoid glucosides, oleuropein and ligustroside.[Pubmed: 21042869]

    METHODS AND RESULTS:
    Hydrolysis of oleoside-type secoiridoid glucosides, oleuropein (1) and Ligustroside (2), in the presence of β-glucosidase provided their aglycones, named (5S,8R,9S)-7-3,4-dihydroxyphenethyl elenolate (3) and (5S,8R,9S)-7-4-hydroxyphenethyl elenolate (4), respectively. The structures of 3 and 4 were identified by spectroscopic means and optical rotation measurements.
    CONCLUSIONS:
    Evaluation of the cytotoxic and epidermal growth factor receptor (EGFR) tyrosine kinase inhibitory activities of compounds 1-4 showed that compounds 3 and 4 exhibited moderate cytotoxicity against a disease-oriented panel of 39 human cancer cell lines in vitro, whereas compound 3 inhibited the enzyme.
    J Chromatogr A. 2006 Apr 21;1112(1-2):311-8.
    Isolation and identification of radical scavengers in olive tree (Olea europaea) wood.[Pubmed: 16426626 ]
    Several extracts of Olea europaea wood (Picual olive cultivar) were obtained with solvents of different polarity and their antioxidant activities determined.
    METHODS AND RESULTS:
    The active compounds were detected in fractions of an ethyl acetate extract using HPLC with on-line radical scavenging detection. After applying different separation techniques, hydroxytyrosol, tyrosol, cycloolivil, 7-deoxyloganic acid, oleuropein and Ligustroside were isolated and characterized. Hydroxytyrosol showed a higher activity than the natural antioxidant rosmarinic acid in scavenging the DPPH model radical.
    CONCLUSIONS:
    Cycloolivil and oleuropein showed stronger activities than the synthetic antioxidant BHT against the same radical. Ligustroside, tyrosol and 7-deoxyloganic acid showed little activity. The latter compound has not been previously identified in the genus Olea.
    Chem Pharm Bull (Tokyo). 2001 Nov;49(11):1471-3.
    In vitro evaluation of secoiridoid glucosides from the fruits of Ligustrum lucidum as antiviral agents.[Pubmed: 11724241]
    Six secoiridoid glucosides, lucidumoside C (1), oleoside dimethylester (2), neonuezhenide (3), oleuropein (4), Ligustroside (5) and lucidumoside A (6), isolated from the fruits of Ligustrum lucidum (Oleaceae), were examined in vitro for their activities against four strains of pathogenic viruses, namely herpes simplex type I virus (HSV-1), influenza type A virus (Flu A), respiratory syncytial virus (RSV) and parainfluenza type 3 virus (Para 3).
    METHODS AND RESULTS:
    Antiviral activities were evaluated by the cytopathic effect (CPE) inhibitory assay. The purpose was to check if the antioxidative potency of these glucosides correlated with their antiviral potency. Results showed that none of the glucosides had any significant activity against HSV-1 and Flu A. Oleuropein, however, showed significant antiviral activities against RSV and Para 3 with IC50 value of 23.4 and 11.7 microg/ml, respectively. Lucidumoside C, oleoside dimethylester and Ligustroside showed potent or moderate antiviral activities against Para 3 with IC50 values of 15.6-20.8 microg/ml.
    CONCLUSIONS:
    These results also documented that the anti-oxidative potency of these secoiriodoid glucosides was not directly related to their antiviral effects.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.9066 mL 9.5329 mL 19.0658 mL 38.1316 mL 47.6644 mL
    5 mM 0.3813 mL 1.9066 mL 3.8132 mL 7.6263 mL 9.5329 mL
    10 mM 0.1907 mL 0.9533 mL 1.9066 mL 3.8132 mL 4.7664 mL
    50 mM 0.0381 mL 0.1907 mL 0.3813 mL 0.7626 mL 0.9533 mL
    100 mM 0.0191 mL 0.0953 mL 0.1907 mL 0.3813 mL 0.4766 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Oleonuezhenide; Oleonuezhenide CFN99228 112693-21-7 C48H64O27 = 1073.0 10mg QQ客服:1413575084
    Hydrangenoside A dimethyl acetal; Hydrangenoside A dimethyl acetal CFN97593 952485-00-6 C33H46O14 = 666.72 5mg QQ客服:2159513211
    (E)-Aldosecologanin; (E)-Aldosecologanin CFN97737 471271-55-3 C34H46O19 = 758.73 5mg QQ客服:215959384
    (Z)-Aldosecologanin (Centauroside); (Z)-Aldosecologanin (Centauroside) CFN95079 82474-97-3 C34H46O19 = 758.73 5mg QQ客服:1457312923
    Nudifloside B ; Nudifloside B CFN89186 297740-98-8 C43H60O22 = 928.92 5mg QQ客服:1413575084
    Jasminin; Jasminin CFN89180 30164-93-3 C26H38O12 = 542.57 5mg QQ客服:2056216494
    迎春花甙; Jasmoside CFN89269 97763-17-2 C43H60O22 = 928.92 5mg QQ客服:1457312923
    Isojasminin; Isojasminin CFN89205 135378-08-4 C26H38O12 = 542.57 5mg QQ客服:1413575084
    4''-Hydroxyisojasminin; 4''-Hydroxyisojasminin CFN89089 135378-09-5 C26H38O13 = 558.57 5mg QQ客服:3257982914
    Nudifloside C ; Nudifloside C CFN89204 297740-99-9 C26H38O12 = 542.57 5mg QQ客服:2056216494

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