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  • Leucodin

    Leucodin

    Leucodin
    产品编号 CFN96803
    CAS编号 17946-87-1
    分子式 = 分子量 C15H18O3 = 246.30
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Sesquiterpenoids
    植物来源 The roots of Scorzonera latifolia (Fisch. and Mey.) DC.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Leucodin CFN96803 17946-87-1 1mg QQ客服:215959384
    Leucodin CFN96803 17946-87-1 5mg QQ客服:215959384
    Leucodin CFN96803 17946-87-1 10mg QQ客服:215959384
    Leucodin CFN96803 17946-87-1 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of the Basque Country (Spain)
  • University of Fribourg (Switzerland)
  • Tohoku University (Japan)
  • Celltrion Chemical Research Institute (Korea)
  • Center for protein Engineering (CIP) (Belgium)
  • Kitasato University (Japan)
  • Periyar University (India)
  • University of Sao Paulo (Brazil)
  • Monash University (Australia)
  • Universit?t Basel (Switzerland)
  • Complutense University of Madrid (Spain)
  • University of East Anglia (United Kingdom)
  • Griffith University (Australia)
  • Universidade Federal de Pernambuco (UFPE) (Brazil)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Genes Genomics.2020, 10.1007
  • Anal Bioanal Chem.2016, 408(1):177-90.
  • Cell Biochem Funct.2018, 36(6):303-311
  • Jour. of Stored Pro & Postharvest Res.2016, 7(3):32-36
  • Pharmaceuticals.2022, 15(4), 402.
  • Life Sci.2019, 216:259-270
  • J Ethnopharmacol.2022, 282:114574.
  • Neurochem Int.2020, 133:104629
  • Kor. J. Pharmacogn.2016, 47(1):62-72
  • Neuropharmacology2019, 151437
  • Molecules.2021, 26(18):5665.
  • J Ethnopharmacol.2017, 206:327-336
  • British Jou. Med.&Med. Research2014, 1802-1811
  • J Biochem Mol Toxicol.2020, 34(7):e22489.
  • Front Microbiol.2021, 12:736780.
  • Nutrients.2017, 10(1)
  • J Biomol Struct Dyn.2023, 1-21.
  • LWT2021, 138:110397.
  • Plants (Basel).2021, 10(2):278.
  • J Traditional Thai Medical Res.2022, 8(1):pp1-14.
  • Nat Commun.2023, 14(1):4540.
  • Applied Biological Chemistry2023, 66:85.
  • Molecules2022, 27(3),1140.
  • ...
  • 生物活性
    Description: Leucodin shows high anti-hypercholesterolemic potential. Leucodin may have anti-allergic activity, it shows a potent inhibitory activity upon the beta-hexosaminidase release from RBL-2H3 cells in a dose-dependent manner with IC50 of 80 microM.
    Targets: TNF-α | MMP(e.g.TIMP)
    In vitro:
    Molecules. 2016 Mar 25;21(4):404.
    The Chemical Composition of Achillea wilhelmsii C. Koch and Its Desirable Effects on Hyperglycemia, Inflammatory Mediators and Hypercholesterolemia as Risk Factors for Cardiometabolic Disease.[Pubmed: 27023504 ]

    METHODS AND RESULTS:
    The chloroform fraction (CF) and ethyl acetate fraction (EAF) both showed a significant ability to reduce the secretion of tumor necrosis factor alpha (TNF-α). The EAF, however, also attenuated the levels of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9). The CF showed the most significant 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) inhibition activity. The five main compounds in the CF were isolated and identified.
    CONCLUSIONS:
    Out of the five compounds in the CF, 1β,10β-epoxydesacetoxymatricarin (CP1) and Leucodin (CP2) showed the highest anti-hypercholesterolemic potential. A molecular docking study provided corresponding results.
    Planta Med. 1998 Aug;64(6):577-8.
    Desacetylmatricarin, an anti-allergic component from Taraxacum platycarpum.[Pubmed: 9741305]

    METHODS AND RESULTS:
    The bioassay-guided fractionation of Taraxacum platycarpum (Compositae) extract led to the isolation of a desacetylmatricarin (1) as an active principle responsible for the anti-allergic property.
    CONCLUSIONS:
    It showed a potent inhibitory activity upon the beta-hexosaminidase release from RBL-2H3 cells in a dose-dependent manner and the IC50 was 7.5 microM. Two structurally related guaianolide sesquiterpenes, achillin and Leucodin, were also examined and their IC50 values were determined as 100 microM and 80 microM, respectively.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.0601 mL 20.3004 mL 40.6009 mL 81.2018 mL 101.5022 mL
    5 mM 0.812 mL 4.0601 mL 8.1202 mL 16.2404 mL 20.3004 mL
    10 mM 0.406 mL 2.03 mL 4.0601 mL 8.1202 mL 10.1502 mL
    50 mM 0.0812 mL 0.406 mL 0.812 mL 1.624 mL 2.03 mL
    100 mM 0.0406 mL 0.203 mL 0.406 mL 0.812 mL 1.015 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    1beta,10beta-Epoxydehydroleucodin; 1beta,10beta-Epoxydehydroleucodin CFN89030 130858-00-3 C15H16O4 = 260.28 5mg QQ客服:215959384
    (3aS,9aS,9bS)-6,9-二甲基-3-亚甲基-4,5,9a,9b-四氢-3aH-薁并[5,4-d]呋喃-2,7-二酮 ; Dehydroleucodine CFN96587 36150-07-9 C15H16O3 = 244.29 5mg QQ客服:1457312923
    Leucodin ; Leucodin CFN96803 17946-87-1 C15H18O3 = 246.30 5mg QQ客服:1413575084
    羟基蓍含蓍素 ; Desacetylmatricarin CFN96955 10180-88-8 C15H18O4 = 262.30 5mg QQ客服:1457312923
    1beta,10beta-Epoxydesacetoxymatricarin; 1beta,10beta-Epoxydesacetoxymatricarin CFN89005 124020-39-9 C15H18O4 = 262.30 5mg QQ客服:2056216494
    杰氏苦苣菜内酯; Jacquilenin CFN95434 7726-34-3 C15H18O4 = 262.3 5mg QQ客服:215959384
    Crepidiaside B; Crepidiaside B CFN95432 101921-35-1 C21H28O9 = 424.5 10mg QQ客服:2056216494
    11beta,13-二氢山莴苣素; 11beta,13-Dihydrolactucin CFN95433 83117-63-9 C15H18O5 = 278.3 10mg QQ客服:2159513211
    Artemyriantholide D; Artemyriantholide D CFN89190 421558-76-1 C30H36O6 = 492.61 5mg QQ客服:1413575084
    去氢木香内酯; Dehydrocostus lactone CFN98720 477-43-0 C15H18O2 = 230.3 20mg QQ客服:3257982914

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