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    Kobophenol A

    产品编号 CFN92530
    CAS编号 124027-58-3
    分子式 = 分子量 C56H44O13 = 925.0
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenols
    植物来源 The herbs of Carex humilis Leyss.
    产品名称 产品编号 CAS编号 包装 QQ客服
    蒿草酚A CFN92530 124027-58-3 1mg QQ客服:215959384
    蒿草酚A CFN92530 124027-58-3 5mg QQ客服:215959384
    蒿草酚A CFN92530 124027-58-3 10mg QQ客服:215959384
    蒿草酚A CFN92530 124027-58-3 20mg QQ客服:215959384
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  • 生物活性
    Description: Kobophenol A has antimicrobial, and anti-inflammatory activities, it might be a candidate for treatment of inflammatory bone diseases relevant to osteoblast cell death. Kobophenol A inhibits AChE activity in a dose-dependent manner, and the IC50 value is 115.8mM. Kobophenol A has protective effect against nitrosative/oxidative or mitochondrial damages resulted in the inhibition of the ROS, intracellular calcium ion level, and mitochondrial transmembrane potential changes on SH-SY5Y cells.
    Targets: p38MAPK | CDK | ROS | Bcl-2/Bax | JNK | AP-1 | NO | NF-kB | MMP(e.g.TIMP)
    In vitro:
    Int Immunopharmacol. 2013 Nov;17(3):704-13.
    Kobophenol A enhances proliferation of human osteoblast-like cells with activation of the p38 pathway.[Pubmed: 24021754]
    Bone cell proliferation, bone formation, and bone resorption are the main factors involved in the homeostasis of the bone mass. Osteoblast death is a problem experienced by postmenopause women. Herbal medicines have attracted considerable attention for use as a drug or a drug substitute in the treatment of bone-related diseases, such as osteoporosis.
    This study investigated the effects of kobophenol A on the proliferation in human osteoblast cells. Kobophenol A stimulated the proliferation of osteoblast cells by the increases in DNA synthesis and the enhancement of cell cycle progression. Kobophenol A stimulation induced the expression of the cyclin B1 and cyclin-dependent kinase 1 (CDK1). Treatment of osteoblast cells with p38 MAPK inhibitor SB203580 significantly inhibited kobophenol A-enhanced proliferation. In addition, kobophenol A induced phosphorylation of p38 MAPK. Treatment of osteoblast cells with kobophenol A resulted in improvement of ROS scavenging activity. Moreover, kobophenol A treatment up-regulated the Bcl-2 level, but down-regulated the level of Bax expression. We also demonstrate that kobophenol A increased alkaline phosphatase (ALP) activity after 2 days.
    Taken together, the results of this study reveal that kobophenol A has proliferative effects and enhances ALP activity in osteoblast cells and these findings provide insights into the development of a therapeutic approach of kobophenol A in the prevention of osteoporosis and other bone disorders.
    Chem Pharm Bull (Tokyo). 2014;62(7):713-8. Epub 2014 Apr 24.
    Kobophenol A inhibits sodium nitroprusside-induced cardiac H9c2 cell death through suppressing activation of JNK and preserving mitochondrial anti-apoptotic Bcl-2 and Mcl-1.[Pubmed: 24759620]
    Sodium nitroprusside (SNP) releases nitric oxide (NO), a powerful vasodilator, and thus widely used in intensive care unit for treating hypertension emergency. However, cardiac toxicity after SNP administration is a clinical problem.
    For finding a natural compound that suppressing SNP-induced cardiac toxicity, we tested the protective potential of kobophenol A (Kob A), purified from the root of Caragana sinica, against the toxic effects of SNP. The severe cardiac H9c2 cell death was induced by SNP (2 mM) treatment. Kob A ameliorated SNP-induced cardiac H9c2 cell death, and this protective effect of Kob A may be related to the inhibition of c-Jun NH2-terminal kinase (JNK) and p38 mitogen-activated protein (MAP) kinase activation following SNP administration. In addition, the downregulation of cellular Bcl-2 and Mcl-1 levels by SNP exposure was strongly abrogated in the presence of Kob A.
    These biological properties of Kob A might provide insights into developing new cardioprotectant against SNP-induced cardiac cell death.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.0811 mL 5.4054 mL 10.8108 mL 21.6216 mL 27.027 mL
    5 mM 0.2162 mL 1.0811 mL 2.1622 mL 4.3243 mL 5.4054 mL
    10 mM 0.1081 mL 0.5405 mL 1.0811 mL 2.1622 mL 2.7027 mL
    50 mM 0.0216 mL 0.1081 mL 0.2162 mL 0.4324 mL 0.5405 mL
    100 mM 0.0108 mL 0.0541 mL 0.1081 mL 0.2162 mL 0.2703 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Caraganaphenol A; Caraganaphenol A CFN95093 174916-31-5 C56H42O13 = 923.0 5mg QQ客服:2932563308
    蒿草酚A; Kobophenol A CFN92530 124027-58-3 C56H44O13 = 925.0 10mg QQ客服:2932563308
    Carasinol B; Carasinol B CFN95042 777857-86-0 C56H44O13 = 925.0 5mg QQ客服:2932563308
    (-)-蛇葡萄素H; (-)-Ampelopsin H CFN93787 N/A C56H42O12 = 907.0 5mg QQ客服:1413575084
    Alpha-葡萄素; alpha-Viniferin CFN97068 62218-13-7 C42H30O9 = 678.7 10mg QQ客服:215959384
    Caraphenol A; Caraphenol A CFN98469 354553-35-8 C42H28O9 = 676.7 5mg QQ客服:2932563308
    葡萄醇D; Viniferol D CFN97082 625096-18-6 C42H32O9 = 680.7 5mg QQ客服:1148253675
    桑呋喃C; Mulberrofuran C CFN96132 77996-04-4 C34H28O9 = 580.6 5mg QQ客服:215959384
    桑呋喃G; Mulberrofuran G CFN92788 87085-00-5 C34H26O8 = 562.6 5mg QQ客服:2932563308
    桑呋喃G五乙酸酯; Mulberrofuran G pentaacetate CFN96253 99217-75-1 C44H36O13 = 772.8 5mg QQ客服:2159513211





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