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  • Kielcorin

    Kielcorin

    Kielcorin
    产品编号 CFN89359
    CAS编号 64280-48-4
    分子式 = 分子量 C24H20O8 = 436.41
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Xanthones
    植物来源 The branches of Kielmeyera variabilis.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Kielcorin CFN89359 64280-48-4 1mg QQ客服:2159513211
    Kielcorin CFN89359 64280-48-4 5mg QQ客服:2159513211
    Kielcorin CFN89359 64280-48-4 10mg QQ客服:2159513211
    Kielcorin CFN89359 64280-48-4 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University Medical Center Mainz (Germany)
  • Shanghai Institute of Biochemistry and Cell Biology (China)
  • Guangzhou Institutes of Biomedicine and Health (China)
  • University of Vigo (Spain)
  • Siksha O Anusandhan University (India)
  • University of Parma (Italy)
  • Korea Institute of Oriental Medicine (Korea)
  • Chang Gung University (Taiwan)
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
  • Martin Luther University of Halle-Wittenberg (Germany)
  • Universidade de Franca (Brazil)
  • Wroclaw Medical University (Poland)
  • University of Malaya (Malaysia)
  • Donald Danforth Plant Science Center (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Pharmacol Rep.2018, 70(6):1195-1201
  • Free Radic Biol Med.2021, 166:104-115.
  • Pharmacol Rep.2017, 69(6):1224-1231
  • Phytochemistry.2017, 141:162-170
  • BMC Cancer. 2021, 21(1):91.
  • Antioxidants.2022, 11(3):592.
  • Enzyme Microb Technol.2022, 161:110111.
  • Metabolites.2020, 10(12):497.
  • Int J Mol Sci.2022, 23(21):12816.
  • Int J Mol Sci.2015, 16(1):1232-51
  • Antioxidants (Basel).2021, 10(10):1638.
  • Int J Mol Sci.2022, 23(23):15213.
  • Phytomedicine.2019, 67:153159
  • Planta Med.2019, 85(9-10):766-773
  • Trop J Pharm Res.2023, 22(3):283-288.
  • J Biomed Sci.2020, 27(1):60.
  • Food and Fermentation Industries2018, 44(371)
  • Int. J. Mol. Sci. 2022, 23(3),1696.
  • Agriculture2022, 12(2),227.
  • Nutrients.2019, 11(4):E936
  • Food Sci Biotechnol.2021, 30(2):217-226.
  • Pest Manag Sci.2019, 75(9):2530-2541
  • Int J Mol Sci.2021, 22(19):10405.
  • ...
  • 生物活性
    Description: Kielcorin shows antibacterial activity against strain EMRSA-16. It also shows in vitro anti-inflammatory (respiratory burst) inhibiting activities using isolated human neutrophils (IC (50) = 965.21 ± 65.80 uM). trans-Kielcorin has hepatoprotective activity, it can prevent tert-butylhydroperoxide-induced lipid peroxidation and cell death in freshly isolated rat hepatocytes.
    Targets: Immunology & Inflammation related | Antifection
    In vitro:
    J Nat Prod. 2016 Mar 25;79(3):470-6.
    Antistaphylococcal Prenylated Acylphoroglucinol and Xanthones from Kielmeyera variabilis.[Pubmed: 26900954 ]

    METHODS AND RESULTS:
    Bioactivity-guided fractionation of the EtOH extract of the branches of Kielmeyera variabilis led to the isolation of a new acylphoroglucinol (1), which was active against all the MRSA strains tested herein, with pronounced activity against strain EMRSA-16. Compound 1 displayed an MIC of 0.5 mg/L as compared with an MIC of 128 mg/L for the control antibiotic norfloxacin. The structure of the new compound was elucidated by 1D and 2D NMR spectroscopic analysis and mass spectrometry, and experimental and calculated ECD were used to determine the absolute configurations. The compounds β-sitosterol (2), stigmasterol (3), ergost-5-en-3-ol (4), and osajaxanthone (5) also occurred in the n-hexane fraction.
    CONCLUSIONS:
    The EtOAc fraction contained nine known xanthones: 3,6-dihydroxy-1,4,8-trimethoxyxanthone (6), 3,5-dihydroxy-4-methoxyxanthone (7), 3,4-dihydroxy-6,8-dimethoxyxanthone (8), 3,4-dihydroxy-2-methoxyxanthone (9), 5-hydroxy-1,3-dimethoxyxanthone (10), 4-hydroxy-2,3-dimethoxyxanthone (11), Kielcorin (12), 3-hydroxy-2-methoxyxanthone (13), and 2-hydroxy-1-methoxyxanthone (14), which showed moderate to low activity against the tested MRSA strains.
    Planta Med. 2011 Dec;77(18):2013-8.
    Anti-inflammatory xanthones from the twigs of Hypericum oblongifolium wall.[Pubmed: 21870324 ]

    METHODS AND RESULTS:
    Two new xanthonolignoids, hypericorin A (1) and hypericorin B (2), along with five known new source compounds, a xanthonolignoid, Kielcorin (3), 4-hydroxy-2,3-dimethoxyxanthone (4), 3,4,5-trihydroxyxanthone (5), 1,3-dihydroxy-5-methoxyxanthone ( 6) and 1,3,7-trihydroxyxanthone (7), were isolated from the stems (twigs) of Hypericum oblongifolium Wall. The structures of the new compounds were deduced on the basis of spectroscopic techniques (EI-MS, HREI-MS, (1)H NMR, (13)C NMR, HMQC, HMBC, and NOESY). We also report herein for the first time the single crystal X-ray structure of compound 6.
    CONCLUSIONS:
    Compounds 1- 7 were screened for their IN VITRO anti-inflammatory (respiratory burst) inhibiting activities using isolated human neutrophils; compounds 1, 2, 3, 5, and 7 showed significant activities (IC (50) = 816.23 ± 73.30, 985.20 ± 55.80, 965.21 ± 65.80, 907.20 ± 50.80, 975.20 ± 81.10 μM, respectively), compound 6 showed moderate activity (IC (50) = 2500.85 ± 50.50 μM), while compound 4 was totally inactive at 1000 μg/mL as compared to the positive control used, indomethacin (IC (50) = 757.99 ± 5.90 μM), and aspirin (IC (50) = 279.44 ± 4.40 μM). Compound 4 was also inactive in comparison with other tested Hypericum compounds.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.2914 mL 11.4571 mL 22.9142 mL 45.8285 mL 57.2856 mL
    5 mM 0.4583 mL 2.2914 mL 4.5828 mL 9.1657 mL 11.4571 mL
    10 mM 0.2291 mL 1.1457 mL 2.2914 mL 4.5828 mL 5.7286 mL
    50 mM 0.0458 mL 0.2291 mL 0.4583 mL 0.9166 mL 1.1457 mL
    100 mM 0.0229 mL 0.1146 mL 0.2291 mL 0.4583 mL 0.5729 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    5-羟基-1-甲氧基双苯吡酮; 5-Hydroxy-1-methoxyxanthone CFN96278 27770-13-4 C14H10O4 = 242.2 5mg QQ客服:1457312923
    2,5-二羟基呫吨酮; 2,5-Dihydroxyxanthone CFN89290 35040-32-5 C13H8O4 = 228.20 5mg QQ客服:215959384
    1,2,5-Trihydroxyxanthone; 1,2,5-Trihydroxyxanthone CFN89304 156640-23-2 C13H8O5 = 244.20 5mg QQ客服:2056216494
    2,5-Dihydroxy-1-methoxyxanthone; 2,5-Dihydroxy-1-methoxyxanthone CFN89295 173220-32-1 C14H10O5 = 258.22 5mg QQ客服:2159513211
    1,4,5-三羟基呫吨酮; Subelliptenone G CFN99684 162473-22-5 C13H8O5 = 244.2 5mg QQ客服:215959384
    铁力木呫吨酮A; Mesuaxanthone A CFN98472 3561-81-7 C14H10O5 = 258.2 5mg QQ客服:215959384
    Tovopyrifolin C; Tovopyrifolin C CFN96578 34211-53-5 C14H10O6 = 274.23 5mg QQ客服:2159513211
    1-羟基-2,3,5-三甲氧基咄酮; 1-Hydroxy-2,3,5-trimethoxyxanthone CFN96272 22804-49-5 C16H14O6 = 302.3 5mg QQ客服:3257982914
    2-羟基-9H-9-氧杂蒽酮; 2-Hydroxyxanthone CFN89262 1915-98-6 C13H8O3 = 212.20 5mg QQ客服:215959384
    3,4-Dihydroxy-2-methoxyxanthone; 3,4-Dihydroxy-2-methoxyxanthone CFN89353 6702-55-2 C14H10O5 = 258.22 5mg QQ客服:2056216494

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