顺式-(+)-凯林内酯

Khellactone

	产品编号	CFN96394
	CAS编号	24144-61-4
	分子式 = 分子量	C₁₄H₁₄O₅ = 262.3
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Coumarins
	植物来源	The roots of Angelica purpuraefolia.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

提供自定义包装

产品名称	产品编号	CAS编号	包装	QQ客服
顺式-(+)-凯林内酯	CFN96394	24144-61-4	1mg	QQ客服：2056216494
顺式-(+)-凯林内酯	CFN96394	24144-61-4	5mg	QQ客服：2056216494
顺式-(+)-凯林内酯	CFN96394	24144-61-4	10mg	QQ客服：2056216494
顺式-(+)-凯林内酯	CFN96394	24144-61-4	20mg	QQ客服：2056216494

存储与注意事项

1. 在您收到产品后请检查产品。如无问题，请将产品存入冰霜并且样品瓶保持密封，产品可以存放长达24个月（2-8摄氏度）。

2. 只要有可能，产品溶解后，您应该在同一天应用于您的实验。但是，如果您需要提前做预实验，或者需要全部溶解，我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。通常，这些可用于长达两周。使用前，打开样品瓶前，我们建议您将产品平衡至室温至少1小时。

3. 需要更多关于溶解度，使用和处理的建议？请发送电子邮件至：service@chemfaces.com

订购流程

1. 在线订购

请联系我们QQ客服

2. 电话订购

请拨打电话：
027-84237683 或 027-84237783

3. 邮件或传真订购

发送电子邮件到: manager@chemfaces.com 或
发送传真到：027-84254680

提供订购信息

为了方便客户的订购，请需要订购ChemFaces产品的客户，在下单的时候请提供下列信息，以供我们快速为您建立发货信息。

1. 产品编号（CAS No.或产品名称）

2. 发货地址

3. 联系方法 (联系人，电话）

4. 开票抬头 (如果需要发票的客户）

5. 发票地址（发货地址与发票地址不同）

发货时间

1. 付款方式为100%预付款客户，我们将在确认收到货款后当天或1-3个工作日发货。

2. 付款方式为月结的客户，我们承诺在收到订单后当天或1-3个工作日内发货。

3. 如果客户所需要的产品，需要重新生产，我们有权告知客户，交货时间需要延期。

ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

University of Bordeaux (France)

Uniwersytet Jagielloński w Krakowie (Poland)

University of Perugia (Italy)

Subang Jaya Medical Centre (Malaysia)

Monash University Malaysia (Malaysia)

Weizmann Institute of Science (Israel)

Kyushu University (Japan)

Universite de Lille1 (France)

Stanford University (USA)

VIT University (India)

Universidad de Buenos Aires (Argentina)

Kazusa DNA Research Institute (Japan)

University of Maryland (USA)

Martin Luther University of Halle-Wittenberg (Germany)

More...

Description:

Khellactone shows antitumor activity,it can suppress the growth of NCI-H460 tumor cells. (+)-4'-cis-Khellactone and (+)-3'-cis-khellactone have antiplasmodial activities, they show notable inhibitory activity against -sensitive strains of with IC(50) values from 1.5 and 2.4 microM.

Targets:

Antifection

In vitro:

Phytother Res. 2010 Mar;24(3):469-71.

Antiplasmodial and cytotoxic activity of khellactone derivatives from Angelica purpuraefolia Chung.[Pubmed: 19960419 ]

The methanolic extract of the rhizomes parts of Agelica purpuraefolia was investigated for its activity against chloroquine-sensitive strains of Plasmodium falciparum using the parasite lactate dehydrogenase assay method.
METHODS AND RESULTS:
Two natural khellactone, (+)-4'-Decanoyl-cis-khellactone (1) and (+)-3'-Decanoyl-cis-khellactone (2) were isolated from the rhizomes parts of A. purpuraefolia. Two compounds were evaluated for in vitro antiplasmodial activities as well as their cytotoxic potential on SK-OV-3 cancer cell line cells. Compounds 1, 2 showed notable growth inhibitory activity against chloroquine-sensitive strains of Plasmodium falciparum with IC(50) values from 1.5 and 2.4 microM. This compound showed no significant cytotoxicity (IC(50) > 100 microM) evaluated using SK-OV-3 cancer cell line cells.
CONCLUSIONS:
This is the first report on the antiplasmodial activity of the compounds from A. purpuraefolia.

In vivo:

Phytother Res. 2007 May;21(5):406-9.

Isolation of coumarins and ferulate from the roots of Angelica purpuraefolia and the antitumor activity of khellactone.[Pubmed: 17236175 ]

A new coumarin, hydroxylomatin (1), was isolated from the CHCl(3)-soluble fraction of the roots of Angelica purpuraefolia, along with one ferulate (2) and three other known coumarins (3-5) including Khellactone (3). The structure of hydroxylomatin (1) was determined to be 3'beta,5'-dihydroxy-3',4'-dihydroseselin (1) by spectroscopic means including 2D-NMR. The modified Mosher's method was used to determine the chiral center at C-1 of compound 2. Khellactone (3) is a major compound of the roots of A. purpuraefolia.
METHODS AND RESULTS:
This study also examined the antitumor activity of Khellactone (3) using a LLC mouse lung carcinoma in the BDF-1 mice and a NCI-H460 human lung carcinoma in a human tumor xenograft model in nude mice. This compound (3) inhibited LLC tumor growth with a T/C (mean value of treated group/mean value of control group) value of 12.9% at a dose of 5 mg/kg and 33.2% at a dose of 10 mg/kg, respectively, in a dose-dependent manner. In addition, it suppressed the growth of NCI-H460 tumor cells, accounting for 81.4% at a dose of 10 mg/kg in nude mice.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
顺式-甲基凯诺内酯; cis-Methylkhellactone	CFN89413	20107-13-5	C₁₅H₁₆O₅ = 276.28	5mg	QQ客服：1413575084
Praeroside II; Praeroside II	CFN96695	86940-46-7	C₂₀H₂₄O₁₀ = 424.40	5mg	QQ客服：2159513211
(+)-沙米丁; Samidin	CFN96375	477-33-8	C₂₁H₂₂O₇ = 386.4	5mg	QQ客服：215959384
Hyuganin D; Hyuganin D	CFN89402	77331-76-1	C₂₀H₂₂O₇ = 374.38	5mg	QQ客服：1413575084
(-)-白花前胡素 A; (-)-Praeruptorin A	CFN89386	14017-71-1	C₂₁H₂₂O₇ = 386.39	5mg	QQ客服：2159513211
白花前胡丙素; Praeruptorin C	CFN98143	72463-77-5	C₂₄H₂₈O₇ = 428.48	20mg	QQ客服：2159513211
(-)-白花前胡素 B; (-)-Praeruptorin B	CFN89387	4970-26-7	C₂₄H₂₆O₇ = 426.45	5mg	QQ客服：215959384
丝立尼亭; Selinidin	CFN90570	19427-82-8	C₁₉H₂₀O₅ = 328.4	5mg	QQ客服：215959384
前胡香豆精E; Qianhucoumarin E	CFN92597	156041-02-0	C₁₉H₁₈O₆ = 342.4	5mg	QQ客服：215959384
前胡香豆精 A; Qianhucoumarin A	CFN92709	150135-35-6	C₁₉H₂₀O₆ = 344.4	5mg	QQ客服：2159513211

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.8124 mL	19.0621 mL	38.1243 mL	76.2486 mL	95.3107 mL
5 mM	0.7625 mL	3.8124 mL	7.6249 mL	15.2497 mL	19.0621 mL
10 mM	0.3812 mL	1.9062 mL	3.8124 mL	7.6249 mL	9.5311 mL
50 mM	0.0762 mL	0.3812 mL	0.7625 mL	1.525 mL	1.9062 mL
100 mM	0.0381 mL	0.1906 mL	0.3812 mL	0.7625 mL	0.9531 mL

顺式-(+)-凯林内酯

Khellactone

信息支持

联系方式