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  • 南五味子素

    Kadsurin

    南五味子素
    产品编号 CFN92728
    CAS编号 51670-40-7
    分子式 = 分子量 C25H30O8 = 458.5
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Lignans
    植物来源 The stems of Kadsura japonica
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    南五味子素 CFN92728 51670-40-7 1mg QQ客服:2159513211
    南五味子素 CFN92728 51670-40-7 5mg QQ客服:2159513211
    南五味子素 CFN92728 51670-40-7 10mg QQ客服:2159513211
    南五味子素 CFN92728 51670-40-7 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Uniwersytet Jagielloński w Krakowie (Poland)
  • Universiti Putra Malaysia(UPM) (Malaysia)
  • Uniwersytet Medyczny w ?odzi (Poland)
  • Weizmann Institute of Science (Israel)
  • Shanghai University of TCM (China)
  • Ain Shams University (Egypt)
  • Utrecht University (Netherlands)
  • University of Parma (Italy)
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
  • Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)
  • Universidad Industrial de Santander (Colombia)
  • Stanford University (USA)
  • Korea Food Research Institute(KFRI) (Korea)
  • Imperial College London (United Kingdom)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Metabolites2023, 13(1), 3.
  • The Pharmaceutical Society of Japan2018, 138(4):571-579
  • Planta Med.2023, 2192-2281
  • Int J Mol Sci.2020, 21(9):3144.
  • Molecules.2020, 25(21):5091.
  • Viruses2023, 15(6), 1377
  • J Microbiol Biotechnol.2020, 30(2):178-186.
  • Fitoterapia.2021, 153:104995.
  • JMicrobiol Biotech Food Sci2021, e4289.
  • Phytomedicine.2018, 40:37-47
  • Food Science and Human Wellness2022, 11(4):965-974
  • Industrial Crops and Products2020, 146:112186
  • Int J Mol Sci.2021, 22(2):770.
  • Molecules.2022, 27(7):2093.
  • Chemistry of Plant Raw Materials2019, 4:135-147
  • Journal of Chromatography A2020, 460942
  • Molecules.2020, 25(11):2599.
  • Biomed Pharmacother.2022, 145:112410.
  • J Pharm Anal.2016, 6(6):363-373
  • Preprints2022, 202211.0388.v1.
  • Environ Toxicol.2023, 23929.
  • Journal of Apicultural Research2021, 60(1)
  • Pharmaceuticals (Basel).2022, 15(8):982.
  • ...
  • 生物活性
    Description: Kadsurin has anti-oxidant activity, it induces enzymes capable of scavenging oxygen radical species in the liver. Kadsurin may be valuable antitumor promoters or chemopreventors.
    Targets: SOD
    In vitro:
    J Nat Prod. 2002 Sep;65(9):1242-5.
    Interiotherins C and D, two new lignans from Kadsura interior and antitumor-promoting effects of related neolignans on Epstein-Barr virus activation.[Pubmed: 12350139]

    METHODS AND RESULTS:
    Two new lignans, interiotherins C (1) and D (2), together with the known compounds interiorin (3), heteroclitin F (4), neokadsuranin (5), heteroclitin D (6), Kadsurin (7), gomisin A (8), schisandrin C (9), interiotherin A (10), angeloylgomisin R (11), gomisin G (12), interiotherin B (13), and gomisin C (14), were isolated from the stems of Kadsura interior. The structures and stereochemistries of the new compounds were determined from mass, CD, and NMR spectral data. Fourteen neolignans were screened as potential antitumor promoters by examining their ability to inhibit Epstein-Barr virus early antigen (EBV-EA) activation (induced by 12-O-tetradecanoylphorbol-13-acetate) in Raji cells. Neokadsuranin (5) and schisandrin C (9) were the most potent compounds.
    CONCLUSIONS:
    These data suggest that some neolignans might be valuable antitumor promoters or chemopreventors.
    In vivo:
    Chem Pharm Bull (Tokyo). 1992 Feb;40(2):406-9.
    Anti-lipid peroxidative effect of an extract of the stems of Kadsura heteroclita and its major constituent, kadsurin, in mice.[Pubmed: 1606637]

    METHODS AND RESULTS:
    Three-days successive p.o. administration of an EtOH extract of the stems of Kadsura heteroclita (Schizandraceae) or its major constituent, kadsurin, resulted in significant decreases of CCl4-induced lipid-peroxidation products, such as thiobarbituric acid reactive substances (TBA-RS), conjugated dienes and fluorescent products in the liver of mice. In contrast, a significant restoration of superoxide dismutase (SOD) activity reduced by CCl4-intoxication was observed in the administered groups, suggesting that the subchronic treatment of mice with the EtOH extract or kadsurin induce enzymes capable of scavenging oxygen radical species in the liver, though the extract and kadsurin themselves may have an anti-oxidant property.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.181 mL 10.9051 mL 21.8103 mL 43.6205 mL 54.5256 mL
    5 mM 0.4362 mL 2.181 mL 4.3621 mL 8.7241 mL 10.9051 mL
    10 mM 0.2181 mL 1.0905 mL 2.181 mL 4.3621 mL 5.4526 mL
    50 mM 0.0436 mL 0.2181 mL 0.4362 mL 0.8724 mL 1.0905 mL
    100 mM 0.0218 mL 0.1091 mL 0.2181 mL 0.4362 mL 0.5453 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    鹤庆五味子癸素; Schisanwilsonin I CFN98732 1181216-84-1 C28H34O9 = 514.6 5mg QQ客服:2056216494
    内南五味子酯 C; Interiotherin C CFN92730 460090-65-7 C30H36O10 = 556.6 5mg QQ客服:2159513211
    滇藏五味子素G; Negsehisandrin G CFN90533 1023744-69-5 C28H36O7 = 484.6 10mg QQ客服:1413575084
    五味子酯乙; Schisantherin B CFN99924 58546-55-7 C28H34O9 = 514.57 20mg QQ客服:2056216494
    五味子酯甲; Schisantherin A CFN99925 58546-56-8 C30H32O9 = 536.56 20mg QQ客服:1413575084
    戈米辛D; Gomisin D CFN90122 60546-10-3 C28H34O10 = 530.56 20mg QQ客服:215959384
    戈米辛 E; Gomisin E CFN96725 72960-21-5 C28H34O9 = 514.57 5mg QQ客服:1457312923
    戈米辛F; Gomisin F CFN92719 62956-47-2 C28H34O9 = 514.6 5mg QQ客服:2056216494
    戈米辛G; Gomisin G CFN90123 62956-48-3 C30H32O9 = 536.6 10mg QQ客服:2056216494
    戈米辛H; Gomisin H CFN94008 66056-20-0 C23H30O7 = 418.5 10mg QQ客服:1413575084

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