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  • 异汉防己甲素

    Isotetrandrine

    异汉防己甲素
    产品编号 CFN98722
    CAS编号 477-57-6
    分子式 = 分子量 C38H42N2O6 = 622.8
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The roots of Stephania tetrandra S.Moore
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    异汉防己甲素 CFN98722 477-57-6 1mg QQ客服:1457312923
    异汉防己甲素 CFN98722 477-57-6 5mg QQ客服:1457312923
    异汉防己甲素 CFN98722 477-57-6 10mg QQ客服:1457312923
    异汉防己甲素 CFN98722 477-57-6 20mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Instituto Politécnico de Bragan?a (Portugal)
  • University of Parma (Italy)
  • University of Hull (United Kingdom)
  • Monash University Sunway Campus (Malaysia)
  • Chulalongkorn University (Thailand)
  • University of Leipzig (Germany)
  • Northeast Normal University Changchun (China)
  • Medizinische Universit?t Wien (Austria)
  • University of Otago (New Zealand)
  • Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)
  • University of Maryland (USA)
  • Instytut Nawozów Sztucznych w Pu?awach (Poland)
  • Calcutta University (India)
  • Complutense University of Madrid (Spain)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • BMC Complement Altern Med.2019, 19(1):325
  • AMB Express2020. 10(1):126.
  • BMC Plant Biol.2022, 22(1):128.
  • Mutlu Yanic S, Ates EG. JOTCSA.2023, 10(4);893-902.
  • Korean J of Crop Science2019, 452-458
  • Pharmacol Res.2022, 182:106346.
  • Molecules.2019, 24(20):3755
  • Nutrients.2022, 14(19):4170.
  • Food Chem.2017, 221:1135-1144
  • Chin Med.2022, 17(1):66.
  • Phytomedicine2022, 104:154318
  • Nat Prod Commun.2018, 10.1177
  • J Ethnopharmacol.2023, 317:116789.
  • Plos One.2019, 15(2):e0220084
  • J Pharm Biomed Anal.2023, 234:115570.
  • Chinese J of Tissue Engineering Res.2022, 26(17): 2636-2641.
  • J Ethnopharmacol.2016, 192:370-381
  • Food Res Int.2020, 128:108778
  • Preprints2022, 2022030063.
  • Agronomy 2021, 11(3),502.
  • J Ginseng Res.2022, 46(1):104-114.
  • J Nutr Biochem.2022, 107:109064.
  • Nature Ecology & Evolution2020, doi: 10.1038
  • ...
  • 生物活性
    Description: Isotetrandrine is a small molecule inhibitor, on various aspects of LPS-induced inflammation in vitro and in vivo. It dose-dependently suppresses the severity of LPS-induced ALI by inactivation of MAPK and NF-κB, which may involve the inhibition of tissue oxidative injury and pulmonary inflammatory process.
    Targets: IL Receptor | NF-kB | MAPK | Nrf2 | HO-1 | JNK
    In vitro:
    J Surg Res. 2014 Apr;187(2):596-604.
    Isotetrandrine protects against lipopolysaccharide-induced acute lung injury by suppression of mitogen-activated protein kinase and nuclear factor-kappa B.[Pubmed: 24331940]
    Mitogen-activated protein kinases (MAPKs) and nuclear factor-kappa B (NF-κB) signaling pathways are pleiotropic regulator of many genes involved in lipopolysaccharide (LPS)-induced acute lung injury (ALI). The present study aimed to reveal the protective effect of Isotetrandrine (ITD), a small molecule inhibitor, on various aspects of LPS-induced inflammation in vitro and in vivo.
    METHODS AND RESULTS:
    In vitro, RAW 264.7 cells were pretreated with different dose of Isotetrandrine 1 h before treatment with 1 mg/L of LPS. In vivo, to induce ALI, male BALB/c mice were injected intranasally with LPS and treated with Isotetrandrine (20 and 40 mg/kg) 1 h before LPS. In vitro, the cytokine levels of tumor necrosis factor-α, interleukin (IL)-1β, and IL-6 in supernatant were reduced by Isotetrandrine. Meanwhile, in vivo, pulmonary inflammatory cell infiltration, myeloperoxidase activity, total cells, neutrophils, macrophages, along with the levels of tumor necrosis factor-α, IL-1β, and IL-6 in bronchoalveolar lavage fluid were dose-dependently attenuated by Isotetrandrine. Furthermore, our data showed that Isotetrandrine significantly inhibited the activation of MAPK and NF-κB, which are induced by LPS in ALI model.
    CONCLUSIONS:
    These results suggested that Isotetrandrine dose-dependently suppressed the severity of LPS-induced ALI by inactivation of MAPK and NF-κB, which may involve the inhibition of tissue oxidative injury and pulmonary inflammatory process.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.6057 mL 8.0283 mL 16.0565 mL 32.113 mL 40.1413 mL
    5 mM 0.3211 mL 1.6057 mL 3.2113 mL 6.4226 mL 8.0283 mL
    10 mM 0.1606 mL 0.8028 mL 1.6057 mL 3.2113 mL 4.0141 mL
    50 mM 0.0321 mL 0.1606 mL 0.3211 mL 0.6423 mL 0.8028 mL
    100 mM 0.0161 mL 0.0803 mL 0.1606 mL 0.3211 mL 0.4014 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    鹤氏唐松草碱; Hernandezine CFN89519 6681-13-6 C39H44N2O7 = 652.77 5mg QQ客服:215959384
    防己诺林碱; 粉防己乙素; 汉防己乙素; 去甲粉防己碱; Fangchinoline CFN99167 436-77-1 C37H40N2O6 = 608.71 20mg QQ客服:1457312923
    (-)-箭毒素; (-)-Curine CFN90532 436-05-5 C36H38N2O6 = 594.69 5mg QQ客服:3257982914
    汉防己乙素; Demethyl tetrandrine CFN90482 33889-68-8 C37H40N2O6 = 608.72 20mg QQ客服:215959384
    Thalrugosidine; Thalrugosidine CFN89510 33954-34-6 C38H42N2O7 = 638.74 5mg QQ客服:1457312923
    异粉防己碱N-2'-氧化物; Isotetrandrine N-2'-oxide CFN97190 70191-83-2 C38H42N2O7 = 638.8 5mg QQ客服:2056216494
    头花千金藤醇灵碱; Cepharanoline CFN91640 27686-34-6 C36H36N2O6 = 592.68 5mg QQ客服:1457312923
    千金藤素; Cepharanthine CFN98570 481-49-2 C37H38N2O6 = 606.71 20mg QQ客服:215959384
    皱唐松草宁碱; Thalrugosaminine CFN89468 22226-73-9 C39H44N2O7 = 652.77 5mg QQ客服:1413575084
    异汉防己甲素; Isotetrandrine CFN98722 477-57-6 C38H42N2O6 = 622.8 5mg QQ客服:3257982914

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