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  • 异柯楠碱

    Isorauhimbine

    异柯楠碱
    产品编号 CFN98762
    CAS编号 483-09-0
    分子式 = 分子量 C21H26N2O3 = 354.5
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The roots of Rauvolfia serpentina
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    异柯楠碱 CFN98762 483-09-0 1mg QQ客服:1413575084
    异柯楠碱 CFN98762 483-09-0 5mg QQ客服:1413575084
    异柯楠碱 CFN98762 483-09-0 10mg QQ客服:1413575084
    异柯楠碱 CFN98762 483-09-0 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • The Australian National University (Australia)
  • Celltrion Chemical Research Institute (Korea)
  • University of South Australia (Australia)
  • Harvard University (USA)
  • University of Beira Interior (Portugal)
  • Julius Kühn-Institut (Germany)
  • Nicolaus Copernicus Uniwersity (Poland)
  • Chiang Mai University (Thailand)
  • University of Toulouse (France)
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  • Institute of Pathophysiology Medical University of Vienna (Austria)
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  • University Medical Center Mainz (Germany)
  • University of Cincinnati (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Phytomedicine Plus2022, 2(1):100207.
  • Biochem Biophys Res Commun.2018, 505(4):1148-1153
  • Appl. Sci.2020, 10(16),5482.
  • JPC-Journal of Planar Chromatography2023, 36:179-190
  • J Chromatogr Sci.2015, 53(5):824-9
  • J Med Food.2021, 24(2):151-160.
  • Separations2021, 8(7),90.
  • TCI CO.2019, US20190151281A1
  • Food Chem.2016, 191:81-90
  • Plants (Basel).2023, 12(22):3877.
  • Molecules.2016, 21(6)
  • US20170000760 A12016, 42740
  • QASCF2022, 14(4).
  • Planta Med.2022, a-1876-3009.
  • Nutrients.2020, 12(11):3448.
  • Int Immunopharmacol.2019, 71:361-371
  • Int Immunopharmacol.2023, 7:127:111322.
  • Tumour Biol.2015, 36(9):7027-34
  • Antioxidants (Basel).2021, 10(11): 1802.
  • Research Square2022, rs.3.rs-1948239
  • Front Plant Sci.2022, 13:982771.
  • Current Pharmaceutical Analysis2017, 13(5)
  • Nutrients.2018, 10(12):E1998
  • ...
  • 生物活性
    Description: 3-Epi-alpha-yohimbine(Isorauhimbine) has alpha adrenoceptor blocking activities,it also has cardiovascular effects.
    Targets: Adrenergic Receptor
    In vivo:
    N.-S. Arch.Pharmacol., 1981, 315(3):227-31.
    Yohimbine diastereoisomers: cardiovascular effects after central and peripheral application in the rat.[Pubmed: 7219571]

    METHODS AND RESULTS:
    The cardiovascular effects of four yohimbine diastereoisomers, yohimbine, rauwolscine, corynanthine, and 3-epi-alpha-yohimbine(Isorauhimbine) , were compared in urethane-anaesthetized and conscious, normotensive Sprague-Dawley rats. Intravenous cumulative infusions (10--500 microgram) of the drugs to anaesthetized rats decreased blood pressure and blunted the pressor response to intravenous adrenaline injections. Corynanthine was the most potent isomer in this regard, followed by yohimbine, rauwolscine, and 3-epi-alpha-yohimbine. Depressor responses following intravenous bolus doses (40 microgram) showed a similar ranking. Intraventricular injections of yohimbine to anaesthetized rats decreased blood pressure dose-dependently, as did injections of corynanthine and rauwolscine. Responses indicated the ranking to be yohimbine greater or equal to rauwolscine greater than corynanthine for this effect at the 40 microgram dose. Heart rate was also decreased by these isomers, but not in a dose-dependent fashion. In conscious rats, the intraventricular injection of these isomers (20 microgram) increased blood pressure and heart rate. No differences were noted in terms of blood pressure responses; but, in causing tachycardia, the ranking was rauwolscine greater than yohimbine greater than corynanthine.
    CONCLUSIONS:
    These data suggest that after intraventricular application in anaesthetized rats, the effects of these alpha-adrenoceptor blockers are related to their individual affinity for the alpha 2 adrenoceptor.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.8209 mL 14.1044 mL 28.2087 mL 56.4175 mL 70.5219 mL
    5 mM 0.5642 mL 2.8209 mL 5.6417 mL 11.2835 mL 14.1044 mL
    10 mM 0.2821 mL 1.4104 mL 2.8209 mL 5.6417 mL 7.0522 mL
    50 mM 0.0564 mL 0.2821 mL 0.5642 mL 1.1283 mL 1.4104 mL
    100 mM 0.0282 mL 0.141 mL 0.2821 mL 0.5642 mL 0.7052 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    利血平氮氧化物; Reserpin N-oxide CFN92583 474-48-6 C33H40N2O10 = 624.7 5mg QQ客服:3257982914
    18-β-羟基-3-表-α-育亨宾; 18-Beta-hydroxy-3-epi-alpha-yohimbine CFN92610 81703-06-2 C21H26N2O4 = 370.5 5mg QQ客服:215959384
    利血平; Reserpine CFN98112 50-55-5 C33H40N2O9 = 608.69 20mg QQ客服:1457312923
    羧酯利血平; Syrosingopine CFN98542 84-36-6 C35H42N2O11 = 666.71 5mg QQ客服:1457312923
    异柯楠碱; Isorauhimbine CFN98762 483-09-0 C21H26N2O3 = 354.5 5mg QQ客服:215959384
    β-育亨宾; beta-Yohimbine CFN98921 549-84-8 C21H26N2O3 = 354.5 5mg QQ客服:2056216494
    α-育亨宾; alpha-Yohimbine CFN99400 131-03-3 C21H26N2O3 = 354.5 5mg QQ客服:1457312923
    盐酸育亨宾; Yohimbine Hydrochloride CFN99511 65-19-0 C21H26N2O3 HCL = 390.91 20mg QQ客服:3257982914
    常绿钩吻碱; Sempervirine CFN97173 6882-99-1 C19H16N2 = 272.4 5mg QQ客服:3257982914
    别育享宾; Allo-Yohimbine CFN92577 522-94-1 C21H26N2O3 = 354.5 5mg QQ客服:215959384

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