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  • Isomahanine

    Isomahanine

    Isomahanine
    产品编号 CFN92200
    CAS编号 144606-95-1
    分子式 = 分子量 C23H25NO2 = 347.5
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The leaves of Murraya koenigii
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Isomahanine CFN92200 144606-95-1 1mg QQ客服:215959384
    Isomahanine CFN92200 144606-95-1 5mg QQ客服:215959384
    Isomahanine CFN92200 144606-95-1 10mg QQ客服:215959384
    Isomahanine CFN92200 144606-95-1 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Center for protein Engineering (CIP) (Belgium)
  • University of Hertfordshire (United Kingdom)
  • University of Fribourg (Switzerland)
  • Universiti Sains Malaysia (Malaysia)
  • Uniwersytet Medyczny w ?odzi (Poland)
  • Univerzita Karlova v Praze (Czech Republic)
  • University of Queensland (Australia)
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • MTT Agrifood Research Finland (Finland)
  • University of Eastern Finland (Finland)
  • University of British Columbia (Canada)
  • Chinese University of Hong Kong (China)
  • The Ohio State University (USA)
  • University of South Australia (Australia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • BMC Plant Biol.2022, 22(1):128.
  • Korean Herb. Med. Inf.2020, 8(2):243-254.
  • Int J Mol Sci.2019, 20(16):E4015
  • Natural Product Communications2020, doi: 10.1177.
  • Sci Rep.2023, 13(1):7475.
  • Research Square2020, doi: 10.21203.
  • VNU Journal of Science: Med.& Pharm. Sci.2022, 38(2):2588-1132.
  • Front Pharmacol.2022, 13:919230.
  • Srinagarind Medical Journal2017, 32(1)
  • Food Sci Nutr.2023, 11(9):5532-5542.
  • Food Res Int.2020, 133:109130.
  • ACS Synth Biol.2020, 9(9):2282-2290.
  • Front Pharmacol.2020, 11:683.
  • Molecules2022, 27(12):3824.
  • Antioxidants (Basel).2022, 11(12):2411.
  • Planta Med.2022, a-1876-3009.
  • Med Sci Monit.2019, 25:9499-9508
  • Hum Exp Toxicol.2017, 36(11):1169-1176
  • Phytomedicine.2019, 57:95-104
  • Int J Mol Sci.2020, 21(9):3144.
  • Anal Chim Acta.2021, 1180:338874.
  • Processes2021, 9(1), 153.
  • Ecol Evol.2022, 12(11):e9459.
  • ...
  • 生物活性
    Description: Isomahanine and mahanine show antibacterial activity towards Flavobacterium columnare and Streptococcus iniae which caused columnaris disease and streptococcosis respectively; isomahanine has the strongest activity against F. columnare (isolate ALM-00-173) and S. iniae (isolate LA94-426) based on 24-h 50% inhibition concentration (IC50) and minimum inhibition concentration (MIC). Isomahanine is also a potent inhibitor of sEH , with IC50 values of 22.565±651.7.
    Targets: Antifection
    In vitro:
    J Agric Food Chem. 2003 Oct 22;51(22):6461-7.
    Comparison of antioxidative properties of carbazole alkaloids from Murraya koenigii leaves.[Pubmed: 14558763]

    METHODS AND RESULTS:
    A new dimeric carbazole alkaloid, 8,10'-[3,3',11,11'-tetrahydro-9,9'-dihydroxy-3,3',5,8'-tetramethyl-3,3'-bis(4-methyl-3-pentenyl)]bipyrano[3,2-a]carbazole (12), was isolated from the CH(2)Cl(2) extract of Murraya koenigii together with six known carbazole alkaloids, koenimbine (6), O-methylmurrayamine A (7), O-methylmahanine (8), Isomahanine (9), bismahanine (10), and bispyrayafoline (11). Their structures were determined on the basis of (1)H and (13)C NMR spectroscopic and mass spectrometric (MS) data. The antioxidative properties of 12 carbazole alkaloids isolated from leaves of M. koenigii were evaluated on the basis of the oil stability index together with their radical scavenging ability against 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical. On the basis of the lag time to reach a steady state, the 12 carbazoles were classified into three groups.
    CONCLUSIONS:
    It is suggested that an aryl hydroxyl substituent on the carbazole rings plays a role in stabilizing the thermal oxidation and rate of reaction against DPPH radical.
    J. Agr. Chem. Env., 2013, 02(4):90-100.
    Antibacterial compounds from Rutaceae with activities against Flavobacterium columnare and Streptococcus iniae[Reference: WebLink]

    METHODS AND RESULTS:
    From the ethyl acetate extract of Murraya koenegii (Rutaceae) leaves, Isomahanine (1) and mahanine (2) were isolated that showed antibacterial activity towards Flavobacterium columnare and Streptococcus iniae which caused columnaris disease and streptococcosis respectively. Isomahanine was found to have the strongest activity against F. columnare (isolate ALM-00-173) and S. iniae (isolate LA94-426) based on 24-h 50% inhibition concentration (IC50) and minimum inhibition concentration (MIC). Although compound (7), a nicotinamide isolated from Amyris texana had the lowest MIC (2.8 ± 0 mg/L) of any of the test compounds against F. columnare, the 24-h IC50 of 14.8 ± 0.6 mg/L was higher than that of Isomahanine and subsequently the 24-h IC50 RDC values for (7) were almost a magnitude of order higher than those obtained for Isomahanine.
    CONCLUSIONS:
    Isomahanine also had the strongest activity against S. iniae, with a 24-h IC50 of 1.3 ± 0.1 mg/L and MIC of 3.5 ± 0 mg/L, respectively.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.8777 mL 14.3885 mL 28.777 mL 57.554 mL 71.9424 mL
    5 mM 0.5755 mL 2.8777 mL 5.7554 mL 11.5108 mL 14.3885 mL
    10 mM 0.2878 mL 1.4388 mL 2.8777 mL 5.7554 mL 7.1942 mL
    50 mM 0.0576 mL 0.2878 mL 0.5755 mL 1.1511 mL 1.4388 mL
    100 mM 0.0288 mL 0.1439 mL 0.2878 mL 0.5755 mL 0.7194 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Clausine E; Clausine E CFN91823 182261-83-2 C14H11NO3 = 241.2 5mg QQ客服:2056216494
    1,6-二羟基-9H-咔唑-3-甲醛; Clausine Z CFN97428 866111-14-0 C13H9NO3 = 227.2 5mg QQ客服:215959384
    1-羟基-6-甲氧基-9H-咔唑-3-甲醛; Clausine I CFN97800 182261-94-5 C14H11NO3 = 241.24 5mg QQ客服:2159513211
    2,8-二羟基-9H-咔唑-3-甲醛; Clauszoline M CFN97796 187110-72-1 C13H9NO3 = 227.22 5mg QQ客服:2056216494
    柯里九里香碱; Curryangine CFN92926 25488-37-3 C23H25NO = 331.45 5mg QQ客服:3257982914
    Murrayamine E; Murrayamine E CFN92927 172617-68-4 C23H25NO2 = 347.45 5mg QQ客服:215959384
    柯九里香甲碱; Koenigicine CFN70319 24123-92-0 C20H21NO3 = 323.4 5mg QQ客服:3257982914
    马汉九里香碱; Mahanimbine CFN92197 21104-28-9 C23H25NO = 331.5 5mg QQ客服:1457312923
    异马汉九里香碱; Isomahanimbine CFN92198 26871-46-5 C23H25NO = 331.5 5mg QQ客服:1413575084
    Mahanine; Mahanine CFN92199 28360-49-8 C23H25NO2 = 347.5 5mg QQ客服:3257982914

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