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  • 异莲花掌苷

    Isolindleyin

    异莲花掌苷
    产品编号 CFN93016
    CAS编号 87075-18-1
    分子式 = 分子量 C23H26O11 = 478.45
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenols
    植物来源 The herbs of Rheum palmatum L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    异莲花掌苷 CFN93016 87075-18-1 1mg QQ客服:2056216494
    异莲花掌苷 CFN93016 87075-18-1 5mg QQ客服:2056216494
    异莲花掌苷 CFN93016 87075-18-1 10mg QQ客服:2056216494
    异莲花掌苷 CFN93016 87075-18-1 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Amsterdam (Netherlands)
  • Srinakharinwirot University (Thailand)
  • Medical University of South Carolina (USA)
  • Lodz University of Technology (Poland)
  • Subang Jaya Medical Centre (Malaysia)
  • Agricultural Research Organization (ARO) (Israel)
  • University of Illinois at Chicago (USA)
  • Universitas Airlangga (Indonesia)
  • Warszawski Uniwersytet Medyczny (Poland)
  • University of Wisconsin-Madison (USA)
  • Auburn University (USA)
  • Washington State University (USA)
  • University Medical Center Mainz (Germany)
  • Seoul National University of Science and Technology (Korea)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int J Biol Macromol.2021, 199:189-200.
  • Key Engineering Materials2022, 931(47-53).
  • US20170000760 A12016, 42740
  • Phytother Res.2022, 10.1002:ptr.7602.
  • Acta Chromatographica2016, 29(3)
  • Pharmacol Rep.2019, 71(2):289-298
  • Bio-protocol2018, 9(14):e3301
  • Molecules. 2013, 18(11):14105-21
  • J. Pharm. Res. Int.2022, 34(58): pp.1-14.
  • International Food Research Journal2018, 25(6):2560-2571
  • Research on Crops.2017, 18(3):569
  • Appl. Sci.2020, 10(5),1713.
  • J Cosmet Dermatol.2022, 21(1):396-402.
  • Food Science&Tech. Res.2022, 28(2):123-132.
  • Journal of Research in Pharmacy.2022, 26(6):p1752-1757.
  • Mol Med Rep.2022, 26(4):299.
  • Environ Toxicol.2023, 38(5):1174-1184.
  • J Chromatogr Sci.2020, 58(6):485-493.
  • Natural Product Communications2020, doi: 10.1177.
  • Antioxidants (Basel).2021, 10(9):1487.
  • Appl. Sci.2020, 10(20),7374.
  • Recent Pat Anticancer Drug Discov.2022, 17(4):416-426.
  • Comparative Clinical Pathology 2021, 30:961-971.
  • ...
  • 生物活性
    Description: Reference standards.
    In vitro:
    Chem Pharm Bull (Tokyo). 2000 Jul;48(7):1055-61.
    Prolyl endopeptidase inhibitory activity of fourteen Kampo formulas and inhibitory constituents of Tokaku-joki-to.[Pubmed: 10923840]
    Prolyl endopeptidase (PEP, EC 3.4.21.26) is an enzyme playing a role in the metabolism of proline-containing neuropeptides which have been suggested to be involved in learning and memory processes.
    METHODS AND RESULTS:
    In screening for PEP inhibitors from fourteen traditional Kampo formulas, we found that Tokaku-joki-to shows a significant inhibitory activity. Examination of the constituents of the Kampo formula resulted in the isolation of two new compounds, cis-3,5,4'-trihydroxystilbene 4'-O-beta-D-(6-O-galloyl)glucopyranoside (10) and 4-(4-hydroxyphenyl)-2-butanone 4'-O-beta-D-(6-O-galloyl-2-O-cinnamoyl)glucopyranoside (16), along with twenty-five known compounds, cinnamic acid (1), protocatechuic acid (2), gallic acid (3), torachrysone 8-O-beta-D-glucoside (4), emodin (5), emodin 8-O-beta-D-glucoside (6), 3,5,4'-trihydroxystilbene 4'-O-beta-D-glucopyranoside (7), 3,5,4'-trihydroxystilbene 4'-O-beta-D-(2-O-galloyl)glucopyranoside (8), 3,5,4'-trihydroxystilbene 4'-O-beta-D-(6-O-galloyl)glucopyranoside (9), 4-(4-hydroxyphenyl)-2-butanone 4'-O-beta-D-glucopyranoside (11), Isolindleyin (12), lindleyin (13), 4(4-hydroxyphenyl)-2-butanone 4'-O-beta-D-(2,6-di-O-galloyl)glucopyranoside (14), 4-(4-hydroxyphenyl)-2-butanone 4'-O-beta-D-(2-O-galloyl-6-O-cinnamoyl)glucopyranoside (15), 1-O-galloylglucose (17), 1,2,6-tri-O-galloylglucose (18), gallic acid 4-O-beta-D-(6-O-galloyl)glucopyranoside (19), liquiritigenin (20), liquiritigenin 4'-O-beta-D-glucoside (21), liquiritigenin 7,4'-diglucoside (22), liquiritigenin 4'-O-beta-D-apiofuranosyl-(1-->2)-beta-D-glucopyranoside (23), licuroside (24), (-)-epicatechin (25), (-)-epicatechin 3-O-gallate (26) and (+)-catechin (27).
    CONCLUSIONS:
    Among these compounds, twelve (7-10, 14-16, 18, 19, 24-26) showed noncompetitive inhibition with an IC50 of 22.9, 3.0, 14.9, 2.8, 10.5, 0.69, 8.2, 0.44, 9.39, 26.5, 28.1 and 0.052 microM, respectively.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.0901 mL 10.4504 mL 20.9008 mL 41.8017 mL 52.2521 mL
    5 mM 0.418 mL 2.0901 mL 4.1802 mL 8.3603 mL 10.4504 mL
    10 mM 0.209 mL 1.045 mL 2.0901 mL 4.1802 mL 5.2252 mL
    50 mM 0.0418 mL 0.209 mL 0.418 mL 0.836 mL 1.045 mL
    100 mM 0.0209 mL 0.1045 mL 0.209 mL 0.418 mL 0.5225 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    伏格列波糖; Voglibose CFN91808 83480-29-9 C10H21NO7 = 267.3 20mg QQ客服:2056216494
    异栓翅芹醇; Isogosferol CFN98890 53319-52-1 C16H14O5 = 286.3 5mg QQ客服:2056216494
    没食子酸辛酯; Octyl Gallate CFN93142 1034-01-1 C15H22O5 = 282.33 20mg QQ客服:2056216494
    甜菊醇-19-葡萄糖苷; Steviol-19-O-Glucoside CFN93339 1185737-16-9 C26H40O8 = 480.59 5mg QQ客服:2056216494

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