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  • 异欧前胡素

    Isoimperatorin

    异欧前胡素
    产品编号 CFN99107
    CAS编号 482-45-1
    分子式 = 分子量 C16H14O4 = 270.28
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Coumarins
    植物来源 The roots of Peucedanum ostruthium L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    异欧前胡素 CFN99107 482-45-1 10mg QQ客服:1413575084
    异欧前胡素 CFN99107 482-45-1 20mg QQ客服:1413575084
    异欧前胡素 CFN99107 482-45-1 50mg QQ客服:1413575084
    异欧前胡素 CFN99107 482-45-1 100mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Utrecht University (Netherlands)
  • Tohoku University (Japan)
  • University of Queensland (Australia)
  • University of Vigo (Spain)
  • Gyeongsang National University (Korea)
  • Washington State University (USA)
  • Universidade Federal de Goias (UFG) (Brazil)
  • St. Jude Children Research Hospital (USA)
  • Wageningen University (Netherlands)
  • National Cancer Center Research Institute (Japan)
  • Universidade do Porto (Portugal)
  • Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
  • Medical University of Gdansk (Poland)
  • Martin Luther University of Halle-Wittenberg (Germany)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • British Jou. Med.&Med. Research2014, 1802-1811
  • Asian Journal of Chemistry2014, 26(8):2425
  • Tumour Biol.2015, 36(12):9385-93
  • Mol Cells.2015, 38(9):765-72
  • Phytomedicine.2016, 23(4):331-9
  • J Drug Target.2016, 24:1-28
  • J Ethnopharmacol.2017, 196:75-83
  • J Ethnopharmacol.2017, 209:305-316
  • Srinagarind Medical Journal2017, 32(1)
  • Oncotarget.2017, 8(53):90925-90947
  • RSC Advances2017, 86
  • BMC Complement Altern Med.2018, 18(1):303
  • Lab Chip.2018, 18(6):971-978
  • Biochem Biophys Res Commun.2018, 495(1):1271-1277
  • Nat Commun.2019, 10(1):2745
  • Food and Agriculture Org. Of the UN2019, 151-160
  • Molecules.2019, 24(17):E3127
  • Environ Toxicol.2019, 34(4):513-520.
  • Pharmaceutical Chemistry Journal2019, 52(12):986-991
  • Int J Food Sci Nutr.2019, 70(7):825-833
  • J of Ana. Chem.2019, 74(11):1113-1121
  • Food Sci Nutr.2019, 8(1):246-256
  • TCI CO.2019, US20190151281A1
  • ...
  • 生物活性
    Description: Isoimperatorin has analgesic, hepatoprotective, antimicrobial, anti-inflammatory, vascular relaxing and anticancer activities. It inhibited the expression of COX, TNF-α, PPAR-γ,ERK1/2, PI3K, and PKC. It showed significant inhibitory effects on acetylcholinesterase (AChE) with the IC50 of 74.6 uM, it also showed different inhibitory effects on all of the six CYP isoenzymes(human CYP1A2, 2B6, 2C9, 2C19, 2D6 and 3A4 enzymes).
    Targets: P450 (e.g. CYP17) | Nrf2 | COX | TNF-α | ERK | Akt | PI3K | PKC | PPAR | AChR
    In vitro:
    Lett Appl Microbiol. 2014 Apr;58(4):344-9.
    In vitro activity of isoimperatorin, alone and in combination, against Mycobacterium tuberculosis.[Pubmed: 24330002]
    Previous studies have shown that isoimperatorin (IO), a furanocoumarin isolated from several medicinal plants, has antimycobacterial activity against Mycobacterium tuberculosis strain H37Rv (ATCC 27294).
    METHODS AND RESULTS:
    This study demonstrated that IO has antimycobacterial activity against 2 drug-sensitive and 6 drug-resistant isolates, with minimum inhibitory concentrations (MICs) of 50-100 μg ml(-1) and 100-200 μg ml(-1), respectively. IO exhibited synergistic antimycobacterial effects with rifampin (RMP), isoniazid (INH) and ethambutol (EMB) against 6 drug-resistant strains, with fractional inhibitory concentration index (FICI) values of 0·133-0·472, 0·123-0·475 and 0·124-0·25, respectively. The IO/RMP, IO/INH and IO/EMB combination treatments had synergistic effects or no interaction in the 2 drug-sensitive strains and the standard strain ATCC 27294. The synergism of combined drugs against drug-resistant strains was better than drug-sensitive strains. No antagonism was observed in with the aforementioned combinations against all strains tested. IO exhibited relatively low cytotoxicity to Vero cells. Our results indicate that IO may serve as promising a template for future antimycobacterial drug development.
    CONCLUSIONS:
    This is the first report on the in vitro synergistic antimycobacterial effects of isoimperatorin (IO) in combination with three first-line drugs: rifampin (RMP), isoniazid (INH) and ethambutol (EMB). The results indicated that the antimycobacterial activity of IO was modest; however, IO was a useful and effective agent against Myco. tuberculosis when it was combined with first-line antimycobacterial drugs and is worthy of further development as a lead compound for the development of novel antimycobacterial therapeutic agents.
    Arch Pharm Res. 2008 Feb;31(2):210-5.
    The effects of isoimperatorin isolated from Angelicae dahuricae on cyclooxygenase-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells.[Pubmed: 18365692]
    Isoimperatorin (4-[(3-Methyl-2-butenyl)oxy]-7H-furo[3,2-g][1]benzopyran-7-one) is a medicinal herbal product that is isolated from the dried roots of Angelicae dahuricae.
    METHODS AND RESULTS:
    Isoimperatorin inhibits the cyclooxygenase-2 (COX-2) and COX-1-dependent phases of prostaglandin D2 (PGD2) generation in bone marrow-derived mast cells (BMMC) in a concentration-dependent manner, with IC50 values of 10.7 microM and 24 microM, respectively. However, this compound was not able to inhibit COX-1 and 2 protein expression in BMMC that were treated with concentrations of up to 50 microM, which indicates that isoimperatorin directly inhibits COX-2 activity. Furthermore, this compound consistently inhibited the production of leukotriene C4 (LTC4), as well as the degranulation reaction in BMMC, with an IC50 value of 5.7 microM and 9 microM, respectively, and these effects occurred in a dose dependent fashion.
    CONCLUSIONS:
    These results demonstrate that isoimperatorin has a dual cyclooxygenase-2 selective/5-lipoxygenase inhibitory activity, and therefore may provide the basis for novel anti-inflammatory drugs.
    J Ethnopharmacol. 2011 Jan 27;133(2):336-44.
    Isoimperatorin, cimiside E and 23-O-acetylshengmanol-3-xyloside from Cimicifugae rhizome inhibit TNF-α-induced VCAM-1 expression in human endothelial cells: involvement of PPAR-γ upregulation and PI3K, ERK1/2, and PKC signal pathways.[Pubmed: 20937376 ]
    Pretreatment of test compounds significantly reduced reactive oxygen species (ROS) production and expression of vascular cell adhesion molecule-1 (VCAM-1), but not intercellular cell adhesion molecule-1 (ICAM-1). Three compounds all dose-dependently increased not only PPAR-γ expression in EA.hy926 cells but inhibited TNF-α-induced phosphorylation of Akt, extracellular-signal-regulated kinase (ERK) and protein kinase C (PKC) with different specificity. Finally, they prevented TNF-α-induced adhesion of U937 monocytic cells to EA.hy926 cells. CONCLUSIONS: The present results show that cimiside E, 23-O-actylshengmanol-3-xyloside, isoimperatorin isolated from Cimicifugae Rhizome selectively inhibits TNF-α-induced expression of VCAM-1 at least by upregulation of PPAR-γ, and signals for ERK1/2, PI3K, and PKC are involved in this effect.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.6999 mL 18.4993 mL 36.9987 mL 73.9973 mL 92.4967 mL
    5 mM 0.74 mL 3.6999 mL 7.3997 mL 14.7995 mL 18.4993 mL
    10 mM 0.37 mL 1.8499 mL 3.6999 mL 7.3997 mL 9.2497 mL
    50 mM 0.074 mL 0.37 mL 0.74 mL 1.4799 mL 1.8499 mL
    100 mM 0.037 mL 0.185 mL 0.37 mL 0.74 mL 0.925 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    6',7'-二羟薄荷素; 6',7'-Dihydroxybergamottin CFN98307 264234-05-1 C21H24O6 = 372.4 10mg QQ客服:3257982914
    6',7'-二羟薄荷素缩丙酮; 6',7'-Dihydroxybergamottin acetonide CFN97165 684217-08-1 C24H28O6 = 412.5 5mg QQ客服:3257982914
    6'-羟基-7'-乙氧基香柠檬亭; 6'-Hydroxy-7'-ethoxybergamottin CFN97583 N/A C23H28O6 = 400.5 5mg QQ客服:1413575084
    8-氧甲基异欧前胡内酯; Cnidilin CFN90590 14348-22-2 C17H16O5 = 300.31 10mg QQ客服:1413575084
    氧化前胡素; Oxypeucedanin CFN90350 737-52-0 C16H14O5 = 286.28 20mg QQ客服:3257982914
    水合氧化前胡素; Oxypeucedanin hydrate CFN90557 2643-85-8 C16H16O6 = 304.29 20mg QQ客服:215959384
    佛手柑素; Bergamotine CFN90592 7380-40-7 C21H22O4 = 338.4 10mg QQ客服:215959384
    羌活醇; Notopterol CFN98563 88206-46-6 C21H22O5 = 354.40 20mg QQ客服:1148253675
    羌活酚; Notoptol CFN95218 88206-49-9 C21H22O5 = 354.4 5mg QQ客服:215959384
    环氧香柠檬素; Epoxybergamottin CFN70306 206978-14-5 C21H22O5 = 354.4 5mg QQ客服:1148253675

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