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  • 异阿魏酸

    Isoferulic acid

    异阿魏酸
    产品编号 CFN98282
    CAS编号 25522-33-2
    分子式 = 分子量 C10H10O4 = 194.2
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenylpropanoids
    植物来源 The roots of Cimicifuga foetida L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    异阿魏酸 CFN98282 25522-33-2 10mg QQ客服:3257982914
    异阿魏酸 CFN98282 25522-33-2 20mg QQ客服:3257982914
    异阿魏酸 CFN98282 25522-33-2 50mg QQ客服:3257982914
    异阿魏酸 CFN98282 25522-33-2 100mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Almansora University (Egypt)
  • Texas A&M University (USA)
  • University of Vienna (Austria)
  • University of Medicine and Pharmacy (Romania)
  • Leibniz Institute of Plant Biochemistry (Germany)
  • Biotech R&D Institute (USA)
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  • Helmholtz Zentrum München (Germany)
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  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Anticancer Res.2014, 34(7):3505-9
  • Faculty of Chem. & Nat. Resource Eng.2014, 62
  • Mol Med Rep.2014, 9(5):1653-9
  • Food Analytical Methods2017, 10:3225–3234
  • Evid Based Complement Alternat Med.2017, 2017:6360836
  • Molecules.2017, 22(2)
  • J Nat Med.2017, 71(2):457-462
  • Yakugaku Zasshi.2018, 138(4):571-579
  • Int J Mol Sci.2018, 19(9):E2601
  • Pak J Pharm Sci.2018, 31:311-315
  • Biochem Biophys Res Commun.2018, 505(4):1148-1153
  • Sci Rep.2018, 8:9267
  • Planta Med.2018, 84(6-07):465-474
  • Front Pharmacol.2018, 9:756
  • Cardiovasc Toxicol.2019, 19(4):297-305
  • Molecules.2019, 24(17):E3127
  • Int J Cosmet Sci.2019, 41(1):12-20
  • New Journal of Chemistry2019, 43:12538-12547
  • J Asian Nat Prod Res.2019, 5:1-17
  • Aquaculture2019, 510:392-399
  • Metabolites.2019, 9(11):E271
  • Front Plant Sci.2020, 10:1705
  • J Nat Med.2020, 74(1):65-75
  • ...
  • 生物活性
    Description: Isoferulic acid is an effective natural antioxidant in both lipid and aqueous media, it may be a new promising anti-glycation agent for the prevention of diabetic complications via inhibition of advanced glycation end products (AGEs) formation and oxidation-dependent protein damage. Isoferulic acid is a novel and potent inhibitor of murine IL-8 production, it also has inhibitory effect on mushroom tyrosinase.
    Targets: HDAC | GLUT | IL Receptor | Antifection
    In vitro:
    Molecules. 2013 May 30;18(6):6439-54.
    Isoferulic acid, a new anti-glycation agent, inhibits fructose- and glucose-mediated protein glycation in vitro.[Pubmed: 23722732]
    The inhibitory activity of isoferulic acid (IFA) on fructose- and glucose-mediated protein glycation and oxidation of bovine serum albumin (BSA) was investigated.
    METHODS AND RESULTS:
    Our data showed that IFA (1.25-5 mM) inhibited the formation of fluorescent advanced glycation end products (AGEs) and non-fluorescent AGE [Nε-(carboxymethyl) lysine: CML], as well as the level of fructosamine. IFA also prevented protein oxidation of BSA indicated by decreasing protein carbonyl formation and protein thiol modification. Furthermore, IFA suppressed the formation of β-cross amyloid structures of BSA.
    CONCLUSIONS:
    Therefore, IFA might be a new promising anti-glycation agent for the prevention of diabetic complications via inhibition of AGEs formation and oxidation-dependent protein damage.
    Nat Prod Commun. 2011 Sep;6(9):1285-8.
    Evaluation of antioxidant activity of isoferulic acid in vitro.[Pubmed: 21941899]
    Isoferulic acid (3-hydroxy-4-methoxycinnamic acid, IFA), the isomer of ferulic acid (4-hydroxy-3-methoxycinnamic acid), is a rare phenolic acid occurring in Rhizoma Cimicifugae. Unlike ferulic acid, which has been well investigated, the antioxidant activity of IFA has not been measured.
    METHODS AND RESULTS:
    In this study, IFA was systematically evaluated for its in vitro antioxidant activity for the first time. IC50 values were calculated of 7.30 +/- 0.57, 4.58 +/- 0.17, 1.08 +/- 0.01, 8.84 +/- 0.43, 7.69 +/- 0.39, 1.57 +/- 0.2, 13.33 +/- 0.49 microg/mL, respectively, for lipid peroxidation, DPPH (1,1-diphenyl-2-picrylhydrazyl radical) and ABTS (3-ethylbenzthiazoline-6-sulfonic acid diammonium salt) radical scavenging, reducing power on Fe3+ and CU2+ ions, and hydroxyl and superoxide anion radical scavenging. Comparison with the IC50 values with those of the positive controls, Trolox and butylated hydroxyanisole (BHA), it can be concluded that isoferulic acid is an effective natural antioxidant in both lipid and aqueous media.
    Planta Med. 1995 Jun;61(3):221-6.
    Inhibitory effect of ferulic acid and isoferulic acid on murine interleukin-8 production in response to influenza virus infections in vitro and in vivo.[Pubmed: 7617763 ]
    We investigated the effect of ferulic acid (FA) and Isoferulic acid (IFA), which are active components of the rhizoma of Cimicifuga species used frequently as anti-inflammatory drugs in Japanese Oriental medicines, on murine interleukin-8 (IL-8) production in response to influenza virus infections in vitro and in vivo by antibody-sandwich enzyme-linked immunosorbent assay.
    METHODS AND RESULTS:
    In the in vitro study, the murine macrophage cell line RAW 264.7 was infected with influenza virus at a dose of 10 plaque forming units (PFU)/cell and cultured in the presence or absence of drugs. Both FA and IFA reduced the IL-8 levels in the 20-h conditioned medium in comparison with control in a dose-dependent manner. The effect of IFA was greater than that of FA: IL-8 levels were reduced to 43% and 56% of the control in the presence of 100 micrograms/ml of IFA and FA, respectively. In the in vivo study, mice were infected with 1,000 PFU of virus and received daily oral administrations of Cimicifuga heracleifolia extract (5 mg/mouse/day), FA (0.5 mg/mouse/day), IFA (0.125 mg/mouse/day), or phosphate buffered saline. The three drugs showed a tendency to reduce IL-8 levels in bronchoalveolar lavage (BAL) obtained 2 days after infection. Moreover, both FA and IFA also significantly reduced the number of exuded neutrophils into BAL. However, the drug administrations did not affect the virus yields in BAL.
    CONCLUSIONS:
    These data suggest that FA and IFA are novel and potent inhibitors of murine IL-8 production and might act as one of the main components of anti-inflammatory rhizoma of Cimicifuga species.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 5.1493 mL 25.7467 mL 51.4933 mL 102.9866 mL 128.7333 mL
    5 mM 1.0299 mL 5.1493 mL 10.2987 mL 20.5973 mL 25.7467 mL
    10 mM 0.5149 mL 2.5747 mL 5.1493 mL 10.2987 mL 12.8733 mL
    50 mM 0.103 mL 0.5149 mL 1.0299 mL 2.0597 mL 2.5747 mL
    100 mM 0.0515 mL 0.2575 mL 0.5149 mL 1.0299 mL 1.2873 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
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