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  • (-)-异延胡索单酚碱

    (-)-Isocorypalmine

    (-)-异延胡索单酚碱
    产品编号 CFN90582
    CAS编号 483-34-1
    分子式 = 分子量 C20H23NO4 = 341.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The tubers of Corydalis yanhusuo W. T. Wang.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    (-)-异延胡索单酚碱 CFN90582 483-34-1 1mg QQ客服:1413575084
    (-)-异延胡索单酚碱 CFN90582 483-34-1 5mg QQ客服:1413575084
    (-)-异延胡索单酚碱 CFN90582 483-34-1 10mg QQ客服:1413575084
    (-)-异延胡索单酚碱 CFN90582 483-34-1 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Korea Intitute of Science and Technology (KIST) (Korea)
  • Regional Crop Research Institute (Korea)
  • Sapienza University of Rome (Italy)
  • Almansora University (Egypt)
  • University of Queensland (Australia)
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  • Uniwersytet Jagielloński w Krakowie (Poland)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • bioRxiv - Biochemistry2023, 548213.
  • Int. J. Mol. Sci.2022, 23(8), 4130.
  • Food Research International2016, 106-113
  • Int J Mol Sci.2018, 19(2)
  • J Mass Spectrom.2022, 57(2):e4810.
  • Chinese J of Tissue Engineering Res.2022, 26(17): 2636-2641.
  • Phytother Res.2019, 33(7):1784-1793
  • J Cell Physiol.2021, 236(3):1950-1966.
  • Genes (Basel).2021, 12(7):1024.
  • Sci Rep.2021, 11(1):14180.
  • Evid Based Complement Alternat Med.2017, 2017:1401279
  • Front Pharmacol.2021, 12:652860.
  • Arch Pharm Res.2015, 38(6):1080-9
  • J Chromatogr B Analyt Technol Biomed Life Sci.2022, 1203:123307.
  • Cell Metab.2020, S1550-4131(20)30002-4
  • BMC Plant Biol.2022, 22(1):128.
  • Bulletin of Health Research2016, 44(4):279-286
  • Food and Chemical Toxicology2020, 111221
  • Int J Mol Sci.2023, 24(17):13230.
  • Plant Physiol Biochem.2021, 160:166-174.
  • J Agric Food Chem.2021, 69(46):14037-14047.
  • Sci Rep.2016, 6:25094
  • Nat Chem Biol.2018, 14(8):760-763
  • ...
  • 生物活性
    Description: (-)-Isocorypalmine has significant antifungal activity. l-isocorypalmine acts as a D1 partial agonist and a D2 antagonist to produce its in vivo effects and may be a promising agent for treatment of cocaine addiction.
    Targets: cAMP | Antifection | Dopamine Receptor
    In vitro:
    FEBS Lett . 2014 Jan 3;588(1):198-204.
    Cloning and characterization of canadine synthase involved in noscapine biosynthesis in opium poppy[Pubmed: 24316226]
    Abstract Noscapine biosynthesis in opium poppy is thought to occur via N-methylcanadine, which would be produced through 9-O-methylation of (S)-scoulerine, methylenedioxy bridge formation on (S)-tetrahydrocolumbamine, and N-methylation of (S)-canadine. Only scoulerine 9-O-methyltransferase has been functionally characterized. We report the isolation and characterization of a cytochrome P450 (CYP719A21) from opium poppy that converts (S)-tetrahydrocolumbamine to (S)-canadine. Recombinant CYP719A21 displayed strict substrate specificity and high affinity (Km=4.63±0.71 μM) for (S)-tetrahydrocolumbamine. Virus-induced gene silencing of CYP719A21 caused a significant increase in (S)-tetrahydrocolumbamine accumulation and a corresponding decrease in the levels of putative downstream intermediates and noscapine in opium poppy plants. Keywords: BIA; Benzylisoquinoline alkaloid; CID; CPR; CYP; Cytochrome P450; ESI; GAPDH; LC–MS/MS; Methylenedioxy bridge; Noscapine biosynthesis; Papaver somniferum; SOMT; TNMT; TRV; VIGS; Virus-induced gene silencing; benzylisoquinoline alkaloid; collision-induced dissociation; cytochrome P450; cytochrome P450 reductase; electrospray ionization; glyceraldehyde 3-phosphate dehydrogenase; liquid chromatography–tandem mass spectrometry; scoulerine 9-O-methyltransferase; tetrahydroprotoberberine N-methyltransferase; tobacco rattle virus; virus-induced gene silencing.
    In vivo:
    Drug Alcohol Depen., 2013, 133(2):693- 703.
    L-isocorypalmine reduces behavioral sensitization and rewarding effects of cocaine in mice by acting on dopamine receptors.[Pubmed: 24080315 ]
    We previously reported isolation of l-isocorypalmine (l-ICP), a mono-demethylated analog of l-tetrahydropalmatine (l-THP), from the plant Corydalis yanhusuo. Here we characterized its in vitro pharmacological properties and examined its effects on cocaine-induced behaviors in mice.
    METHODS AND RESULTS:
    Receptor binding, cAMP and [(35)S]GTPγS assays were used to examine pharmacological actions of l-ICP in vitro. Effects of l-ICP on cocaine-induced locomotor hyperactivity and sensitization and conditioned place preference (CPP) in mice were investigated. HPLC was employed to analyze metabolites of l-ICP in mouse serum. Among more than 40 targets screened, l-ICP and l-THP bound only to dopamine (DA) receptors. l-ICP was a high-affinity partial agonist of D1 and D5 receptors and a moderate-affinity antagonist of D2, D3 and D4 receptors, whereas l-THP bound to only D1 and D5 receptors, with lower affinities than l-ICP. At 10mg/kg (i.p.), l-ICP inhibited spontaneous locomotor activity for a shorter time than l-THP. Pretreatment with l-ICP reduced cocaine-induced locomotor hyperactivities. Administration of l-ICP before cocaine once a day for 5 days reduced cocaine-induced locomotor sensitization on days 5 and 13 after 7 days of withdrawal. Pretreatment with l-ICP before cocaine daily for 6 days blocked cocaine-induced CPP, while l-ICP itself did not cause preference or aversion. HPLC analysis showed that l-ICP was the main compound in mouse serum following i.p. injection of l-ICP.
    CONCLUSIONS:
    l-ICP likely acts as a D1 partial agonist and a D2 antagonist to produce its in vivo effects and may be a promising agent for treatment of cocaine addiction.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.9291 mL 14.6456 mL 29.2912 mL 58.5823 mL 73.2279 mL
    5 mM 0.5858 mL 2.9291 mL 5.8582 mL 11.7165 mL 14.6456 mL
    10 mM 0.2929 mL 1.4646 mL 2.9291 mL 5.8582 mL 7.3228 mL
    50 mM 0.0586 mL 0.2929 mL 0.5858 mL 1.1716 mL 1.4646 mL
    100 mM 0.0293 mL 0.1465 mL 0.2929 mL 0.5858 mL 0.7323 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    四氢黄连碱,人血草碱; Tetrahydrocoptisine CFN90416 7461-02-1 C19H17NO4 = 323.12 20mg QQ客服:215959384
    盐酸人血草碱; Stylopine hydrochloride CFN96656 96087-21-7 C19H18ClNO4 = 359.81 5mg QQ客服:1413575084
    左旋千金藤啶碱; L-Stepholidine CFN90457 16562-13-3 C19H21NO4 = 327.37 20mg QQ客服:2056216494
    (S)-金黄紫堇碱; Scoulerine CFN96330 6451-73-6 C19H21NO4 = 327.4 5mg QQ客服:1413575084
    L-四氢小檗碱; Tetrahydroberberine CFN90506 522-97-4 C20H21O4N = 339.38 20mg QQ客服:3257982914
    华紫堇碱;碎叶紫堇碱; Cheilanthifoline CFN90945 483-44-3 C19H19NO4 = 325.36 10mg QQ客服:215959384
    四氢表小檗碱; Tetrahydroepiberberine CFN90507 38853-67-7 C20H21NO4 = 339.15 10mg QQ客服:1413575084
    延胡索单酚碱; Corypalmine CFN97021 6018-40-2 C20H23NO4 = 341.4 5mg QQ客服:2159513211
    (-)-异延胡索单酚碱; (-)-Isocorypalmine CFN90582 483-34-1 C20H23NO4 = 341.4 10mg QQ客服:2159513211
    N-甲基四氢非洲防己碱; N-Methyltetrahydrocolumbamine CFN95590 92758-34-4 C21H26NO4+ = 356.4 10mg QQ客服:215959384

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