鸢尾酚酮3-C-beta-D-吡喃葡萄糖苷

Iriflophenone 3-C-beta-D-glucopyranoside

	产品编号	CFN99063
	CAS编号	104669-02-5
	分子式 = 分子量	C₁₉H₂₀O₁₀ = 408.4
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Xanthones
	植物来源	The herbs of Aquilaria sinensis
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产品名称	产品编号	CAS编号	包装	QQ客服
鸢尾酚酮3-C-beta-D-吡喃葡萄糖苷	CFN99063	104669-02-5	1mg	QQ客服：1457312923
鸢尾酚酮3-C-beta-D-吡喃葡萄糖苷	CFN99063	104669-02-5	5mg	QQ客服：1457312923
鸢尾酚酮3-C-beta-D-吡喃葡萄糖苷	CFN99063	104669-02-5	10mg	QQ客服：1457312923
鸢尾酚酮3-C-beta-D-吡喃葡萄糖苷	CFN99063	104669-02-5	20mg	QQ客服：1457312923

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Description:

Iriflophenone-3-C-β-d-glucoside shows potent inhibitory activity against α-glucosidase. Iriflophenone 3-C-β-D-glucoside and mangiferin which along with 3 β taraxerol and other sterols could be contributing to the cholesterol lowering activity. Iriflophenone-3- C -glucoside has antioxidant activity, it presents no radical scavenging ability against DPPH , but scavenges ABTS + and peroxyl radicals (TEAC ABTS of 1.04 and TEAC ORAC of 3.61).

In vitro:

J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Mar 1;951-952:164-71.

Iriflophenone-3-C-glucoside from Cyclopia genistoides: isolation and quantitative comparison of antioxidant capacity with mangiferin and isomangiferin using on-line HPLC antioxidant assays.[Pubmed: 24566268 ]

METHODS AND RESULTS:
The benzophenone, iriflophenone-3-C-glucoside, was isolated from Cyclopia genistoides using a combination of fluid-fluid extraction, high performance counter-current chromatography (HPCCC) and semi-preparative high performance liquid chromatography (HPLC). The microplate oxygen radical absorbance capacity (ORAC) assay, with fluorescein as probe, was adapted for use in an on-line HPLC configuration. The method was validated using a mixture of authentic standards including iriflophenone-3-C-glucoside(Iriflophenone 3-C-beta-D-glucopyranoside), and the xanthones, mangiferin and isomangiferin. Trolox (6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid) was included in the mixture for calculation of Trolox equivalent antioxidant capacity (TEAC) values. Using the on-line HPLC-ORAC assay, as well as 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS(+)) on-line assays, the antioxidant activity of iriflophenone-3-C-glucoside(Iriflophenone 3-C-beta-D-glucopyranoside) and isomangiferin was demonstrated for the first time.
CONCLUSIONS:
Iriflophenone-3-C-glucoside(Iriflophenone 3-C-beta-D-glucopyranoside) presented no radical scavenging ability against DPPH, but scavenged ABTS(+) and peroxyl radicals (TEACABTS of 1.04 and TEACORAC of 3.61). Isomangiferin showed slightly lower antioxidant capacity than mangiferin against DPPH (TEACDPPH of 0.57 vs. 0.62), but higher capacity against ABTS(+) (TEACABTS of 1.82 vs. 1.67) and peroxyl radical (TEACORAC of 4.14 vs. 3.69) than mangiferin. The on-line HPLC-ORAC assay was shown to be more sensitive for radical scavengers, but at the same time less selective for rapid radical scavengers than the DPPH assay.

In vivo:

Pharmacognosy Res. 2017 Jan-Mar;9(1):21-26.

Evaluation of Cholesterol-lowering Activity of Standardized Extract of Mangifera indica in Albino Wistar Rats.[Pubmed: 28250649 ]

Cholesterol lowering activity of Mangifera indica L. has been determined by earlier researchers and kernel, leaf and bark have shown significant activity. However, the specific cholesterol lowering activity of leaf methanol extract has not been determined.
METHODS AND RESULTS:
The present study involved evaluation of cholesterol lowering potential of methanol extract of M. indica leaves using high cholesterol diet model in albino Wistar rats. The acute oral toxicity at a dose of 5000 mg/ kg body weight was also determined in female albino Wistar rats. Phytoconstituents Iriflophenone 3-C-beta-D-glucopyranoside and mangiferin were quantified in methanol extracts of different varieties of mango leaves using high performance liquid chromatography. Significant cholesterol lowering activity was observed with methanol extract of M. indica leaves, at dose of 90 mg/kg body weight in rats and it was also found to be safe at dose of 5000 mg/kg rat body. Iriflophenone 3-C-beta-D-glucopyranoside and mangiferin were found to be in the range of 1.2 to 2.8% w/w and 3.9 to 4.6% w/w, respectively which along with 3 β taraxerol and other sterols could be contributing to the cholesterol lowering activity of mango leaves extract.
CONCLUSIONS:
The phytosterols rich extract of Mangifera indica leaves is a good source of nutraceutical ingredient that have the potential to lower serum cholesterol levels.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
2,5-二羟基-4-甲氧基二苯甲酮; Cearoin	CFN89497	52811-37-7	C₁₄H₁₂O₄ = 244.24	5mg	QQ客服：2056216494
2,6,4’-三羟基-4-甲氧基二苯甲酮; 2,6,4'-Trihydroxy-4-methoxybenzophenone	CFN89307	55051-85-9	C₁₄H₁₂O₅ = 260.24	10mg	QQ客服：3257982914
桑橙素，2,3',4,4',6-五羟基二苯甲酮; Maclurin	CFN98836	519-34-6	C₁₃H₁₀O₆ = 262.2	5mg	QQ客服：3257982914
鸢尾酚酮; Iriflophenone	CFN98864	52591-10-3	C₁₃H₁₀O₅ = 246.2	5mg	QQ客服：3257982914
二甲基穗罗汉松树脂酚; Dimethylmatairesinol	CFN97524	943989-68-2	C₁₉H₂₀O₉ = 392.4	5mg	QQ客服：2159513211
鸢尾酚酮3-C-beta-D-吡喃葡萄糖苷; Iriflophenone 3-C-beta-D-glucopyranoside	CFN99063	104669-02-5	C₁₉H₂₀O₁₀ = 408.4	5 mg	QQ客服：2056216494
硫赭曲菌素; Sulochrin	CFN96651	519-57-3	C₁₇H₁₆O₇ = 332.30	5mg	QQ客服：1413575084
Monomethylsulochrin ; Monomethylsulochrin	CFN96952	10056-14-1	C₁₈H₁₈O₇ = 346.33	5mg	QQ客服：3257982914
9-Dehydroxyeurotinone; 9-Dehydroxyeurotinone	CFN89103	1360606-85-4	C₁₅H₁₂O₅ = 272.25	5mg	QQ客服：1457312923
(2,3-二羟基苯基)(2-羟基-4,6-二甲氧基苯基)甲酮; 2,2',3'-Trihydroxy-4,6-dimethoxybenzophenone	CFN98091	219861-73-1	C₁₅H₁₄O₆ = 290.3	5mg	QQ客服：2056216494

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.4486 mL	12.2429 mL	24.4858 mL	48.9716 mL	61.2145 mL
5 mM	0.4897 mL	2.4486 mL	4.8972 mL	9.7943 mL	12.2429 mL
10 mM	0.2449 mL	1.2243 mL	2.4486 mL	4.8972 mL	6.1214 mL
50 mM	0.049 mL	0.2449 mL	0.4897 mL	0.9794 mL	1.2243 mL
100 mM	0.0245 mL	0.1224 mL	0.2449 mL	0.4897 mL	0.6121 mL

鸢尾酚酮3-C-beta-D-吡喃葡萄糖苷

Iriflophenone 3-C-beta-D-glucopyranoside

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