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  • 醋酸因香酚

    Incensole acetate

    醋酸因香酚
    产品编号 CFN93207
    CAS编号 34701-53-6
    分子式 = 分子量 C22H36O3 = 348.5
    产品纯度 >=98%
    物理属性 Oil
    化合物类型 Diterpenoids
    植物来源 The resin of Boswellia carterii Birdw.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    醋酸因香酚 CFN93207 34701-53-6 10mg QQ客服:3257982914
    醋酸因香酚 CFN93207 34701-53-6 20mg QQ客服:3257982914
    醋酸因香酚 CFN93207 34701-53-6 50mg QQ客服:3257982914
    醋酸因香酚 CFN93207 34701-53-6 100mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • University of Leipzig (Germany)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules.2021, 26(3):695.
  • BMC Complement Med Ther.2023, 23(1):264.
  • Int J Mol Sci.2022, 23(11):6172.
  • Microchemical Journal2018, 137:168-173
  • Int. Conference on Med. Sci. and Bio.2017, 17973
  • Int Immunopharmacol.2021, 100:108073.
  • Heliyon.2023, 9:e21652.
  • J Appl Toxicol.2020, 40(7):965-978.
  • FASEB J.2019, 33(2):2026-2036
  • Inflammation.2021, doi: 10.1007
  • J Ethnopharmacol.2017, 197:157-164
  • Drug Des Devel Ther.2023, 17:2461-2479.
  • BMC Plant Biol.2020, 20(1):214.
  • J Sep Sci.2022, 45(18):3556-3566.
  • Inflammation.2020, 43(5):1716-1728.
  • Phytother Res.2019, 33(5):1490-1500
  • BMB Rep.2018, 51(5):249-254
  • Chin J Pharm Anal.2019, 39(7):1217-1228
  • Curr Eye Res.2018, 43(1):27-34
  • Nutrients.2019, 12(1)
  • Antioxidants (Basel).2021, 10(8):1300.
  • J.Pharm. & Biome. Anal.2023, 2: 100018.
  • Biomed Pharmacother.2019, 116:108987
  • ...
  • 生物活性
    Description: Incensole acetate is a novel anti-inflammatory compound that inhibits NF-κB activation. Incensole acetate has protective effects on cerebral ischemic injury, it can reduce depressive-like behavior and modulate hippocampal BDNF and CRF expression of submissive animals.
    Targets: NF-kB | TRPV | TGF-β/Smad | TNF-α | IL Receptor
    In vivo:
    Brain Res. 2012 Mar 14;1443:89-97. doi: 10.1016/j.brainres.2012.01.001. Epub 2012 Jan 9.
    Protective effects of incensole acetate on cerebral ischemic injury.[Pubmed: 22284622]
    The resin of Boswellia species is a major anti-inflammatory agent that has been used for centuries to treat various conditions including injuries and inflammatory conditions. Incensole acetate (IA), a major constituent of this resin, has been shown to inhibit NF-κB activation and concomitant inflammation, as well as the neurological deficit following head trauma.
    METHODS AND RESULTS:
    Here, we show that IA protects against ischemic neuronal damage and reperfusion injury in mice, attenuating the inflammatory nature of ischemic damage. IA given post-ischemia, reduced infarct volumes and improved neurological activities in the mouse model of ischemic injury in a dose dependent fashion. The protection from damage was accompanied by inhibition of TNF-α, IL-1β and TGF-β expression, as well as NF-κB activation following injury. In addition, IA is shown to have a therapeutic window of treatment up to 6h after ischemic injury. Finally, the protective effects of IA were partially mediated by TRPV3 channels as determined by the TRPV3 deficient mice and channel blocker studies.
    CONCLUSIONS:
    This study suggests that the anti-inflammatory and neuroprotective activities of IA may serve as a novel therapeutic treatment for ischemic and reperfusion injury, and as a tool in the ongoing research of mechanisms for neurological damage.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.8694 mL 14.3472 mL 28.6944 mL 57.3888 mL 71.736 mL
    5 mM 0.5739 mL 2.8694 mL 5.7389 mL 11.4778 mL 14.3472 mL
    10 mM 0.2869 mL 1.4347 mL 2.8694 mL 5.7389 mL 7.1736 mL
    50 mM 0.0574 mL 0.2869 mL 0.5739 mL 1.1478 mL 1.4347 mL
    100 mM 0.0287 mL 0.1435 mL 0.2869 mL 0.5739 mL 0.7174 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    美伐他汀; Mevastatin CFN90426 73573-88-3 C23H34O5 = 390.51 20mg QQ客服:215959384
    洛伐他汀; Lovastatin CFN99961 75330-75-5 C24H36O5 = 404.54 20mg QQ客服:1413575084
    辛伐他汀,斯伐他汀; Simvastatin CFN90427 79902-63-9 C25H38O5 = 418.56 20mg QQ客服:215959384
    三白草酮; Sauchinone CFN90153 177931-17-8 C20H20O6 = 356.36 20mg QQ客服:1413575084
    Fischeria A; Fischeria A CFN92879 221456-63-9 C19H28O2 = 288.4 5mg QQ客服:2159513211
    Kongensin A; Kongensin A CFN97452 885315-96-8 C22H30O5 = 374.5 5mg QQ客服:2159513211
    3,10-二羟基-5,11-二薄荷二烯-4,9-二酮; 3,10-Dihydroxy-5,11-dielmenthadiene-4,9-dione CFN99078 106623-23-8 C20H28O4 = 332.4 5mg QQ客服:1457312923
    因香酚; Incensole CFN93208 22419-74-5 C20H34O2 = 306.5 20mg QQ客服:2159513211
    醋酸因香酚; Incensole acetate CFN93207 34701-53-6 C22H36O3 = 348.5 20mg QQ客服:2159513211

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