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  • 7alpha-羟基谷甾醇3-O-beta-D-葡萄糖苷

    Ikshusterol 3-O-glucoside

    7alpha-羟基谷甾醇3-O-beta-D-葡萄糖苷
    产品编号 CFN99217
    CAS编号 112137-81-2
    分子式 = 分子量 C35H60O7 = 592.9
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Steroids
    植物来源 The herbs of Urtica dioica
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    7alpha-羟基谷甾醇3-O-beta-D-葡萄糖苷 CFN99217 112137-81-2 1mg QQ客服:3257982914
    7alpha-羟基谷甾醇3-O-beta-D-葡萄糖苷 CFN99217 112137-81-2 5mg QQ客服:3257982914
    7alpha-羟基谷甾醇3-O-beta-D-葡萄糖苷 CFN99217 112137-81-2 10mg QQ客服:3257982914
    7alpha-羟基谷甾醇3-O-beta-D-葡萄糖苷 CFN99217 112137-81-2 20mg QQ客服:3257982914
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
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    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Pak J Pharm Sci.2019, 32(6)
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  • Chem Biol Interact.2019, 315:108910
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  • Int J Food Sci Nutr.2019, 70(7):825-833
  • iScience.2023, 26(9):107602.
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  • Medicinal Chemistry Research 2021, 30:1117-1124.
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  • Exp Parasitol.2017, 183:160-166
  • HortTechnology2016, 26(6):816-819
  • Sci Rep. 2018, 10590
  • Food Quality and Safety2018, 2:213-219
  • J Biol Chem.2021, 297(6):101362.
  • ...
  • 生物活性
    Description: Ikshusterol 3-O-glucoside has a potent snake-venom neutralizing capacity and it might be a potential molecule for the therapeutic treatment for snakebites.
    Targets: PLA2
    In vitro:
    Journal of Biomolecular Structure and Dynamics, 2017:1-35.
    Computational and in vitro insights on snake venom phospholipase A2 inhibitor of phytocompound ikshusterol3-O-glucoside of Clematis gouriana Roxb. ex DC.[Reference: WebLink]
    Ikshusterol 3-O-glucoside was isolated from Clematis gouriana Roxb. ex DC. root. A structure of the isolated compound was determined on the basis of various spectroscopic interpretations (UV, NMR, FTIR, and GC-MS-EI). This structure was submitted in the PubChem compound database (SID 249494133).
    METHODS AND RESULTS:
    SID 249494133 was carried out by density functional theory calculation to observe the chemical stability and electrostatic potential of this compound. The absorption, distribution, metabolism, and excretion property of this compound was predicted to evaluate the drug likeness and toxicity. In addition, molecular docking, quantum polarized ligand docking, prime MMGBSA calculation, and induced fit docking were performed to predict the binding status of SID 249494133 with the active site of phospholipase A2 (PLA2) (PDB ID: 1A3D). The stability of the compound in the active site of PLA2 was carried out using molecular dynamics simulation. Further, the anti-venom activity of the compound was assessed using the PLA2 assay against Naja naja (Indian cobra) crude venom.
    CONCLUSIONS:
    The results strongly show that Ikshusterol 3-O-glucoside has a potent snake-venom neutralizing capacity and it might be a potential molecule for the therapeutic treatment for snakebites.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.6866 mL 8.4331 mL 16.8663 mL 33.7325 mL 42.1656 mL
    5 mM 0.3373 mL 1.6866 mL 3.3733 mL 6.7465 mL 8.4331 mL
    10 mM 0.1687 mL 0.8433 mL 1.6866 mL 3.3733 mL 4.2166 mL
    50 mM 0.0337 mL 0.1687 mL 0.3373 mL 0.6747 mL 0.8433 mL
    100 mM 0.0169 mL 0.0843 mL 0.1687 mL 0.3373 mL 0.4217 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    赤桐甾醇葡糖苷; Clerosterol glucoside CFN99351 123621-00-1 C35H58O6 = 574.8 5mg QQ客服:2159513211
    22-脱氢赤桐甾醇葡糖苷; 22-Dehydroclerosterol glucoside CFN99480 143815-99-0 C35H56O6 = 572.8 5mg QQ客服:3257982914
    豆甾醇葡萄糖甙; Stigmasterol glucoside CFN98000 19716-26-8 C35H58O6 = 574.8 5mg QQ客服:215959384
    胡萝卜苷; Daucosterol CFN98713 474-58-8 C35H60O6 = 576.9 20mg QQ客服:215959384
    Sitoindoside I; Sitoindoside I CFN99866 18749-71-8 C51H90O7 = 815.3 5mg QQ客服:2159513211
    7alpha-羟基谷甾醇3-O-beta-D-葡萄糖苷; Ikshusterol 3-O-glucoside CFN99217 112137-81-2 C35H60O7 = 592.9 5mg QQ客服:3257982914
    alpha-波菜甾醇葡糖苷; alpha-Spinasterol glucoside CFN99824 1745-36-4 C35H58O6 = 574.8 5mg QQ客服:2159513211

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