Info: Read More
  • 中药标准品生产商,产品定制服务
  • 金丝桃素

    Hypericin

    金丝桃素
    产品编号 CFN99188
    CAS编号 548-04-9
    分子式 = 分子量 C30H16O8 = 504.45
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Anthraquinones
    植物来源 The herbs of Hypericum perforatum L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    金丝桃素 CFN99188 548-04-9 10mg QQ客服:2056216494
    金丝桃素 CFN99188 548-04-9 20mg QQ客服:2056216494
    金丝桃素 CFN99188 548-04-9 50mg QQ客服:2056216494
    金丝桃素 CFN99188 548-04-9 100mg QQ客服:2056216494
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Uniwersytet Jagielloński w Krakowie (Poland)
  • Korea Institute of Oriental Medicine (Korea)
  • Imperial College London (United Kingdom)
  • National Research Council of Canada (Canada)
  • University of British Columbia (Canada)
  • National Cancer Institute (USA)
  • Warszawski Uniwersytet Medyczny (Poland)
  • Funda??o Universitária de Desenvolvimento (Brazil)
  • Shanghai University of TCM (China)
  • Universidade da Beira Interior (Germany)
  • University of Medicine and Pharmacy (Romania)
  • Calcutta University (India)
  • University of Auckland (New Zealand)
  • University of Pretoria (South Africa)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Separations2021, 8(6),80.
  • Korean Journal of Pharmacognosy2018, 49(3):270-277
  • Int. J. of Food Properties2017, S108-S118
  • Viruses.2021, 13(11):2118.
  • Nutrients.2021, 13(1):254.
  • Oxid Med Cell Longev2019, 9056845:13
  • The Journal of Animal & Plant Sciences.2020, 30(6):1366-1373
  • Pharmaceuticals (Basel).2022, 15(8):982.
  • Molecules.2016, 21(6)
  • Evid Based Complement Alternat Med.2016, 2016:4357656
  • Vietnam Journal of Food Control2022, 5(3):pp.390-401.
  • Anticancer Res.2020, 40(10):5529-5538.
  • Plants (Basel).2021, 10(6):1119.
  • Heliyon2020, 6(6):e04337.
  • Molecules2022, 27(12):3824.
  • Trop J Nat Prod Res.2019, 3(1):6-9
  • Food Res Int.2017, 96:40-45
  • Braz J Med Biol Res.2021, 54(12):e11183.
  • Pharmacognosy Journal.2022, 14,4,327-337.
  • J. Pharm. Res. Int.2022, 34(58): pp.1-14.
  • Nat Prod Sci.2019, 25(3):238
  • Antioxidants (Basel).2020, 9(6):544.
  • China Pharmacy2015, 26(27)
  • ...
  • 生物活性
    Description: Hypericin is a photosensitive antiviral with anticancer and antidepressant agent . It can inhibit tyrosine kinases with IC50 of 7.5 μM. It can induce both apoptosis and necrosis in a concentration and light dose-dependent fashion, and inhibit RANKL-mediated osteoclastogenesis via affecting ERK signalling in vitro and suppresses wear particle-induced osteolysis in vivo.
    Targets: PKC | ERK | NF-kB | JNK | p38MAPK
    In vitro:
    Int J Biochem Cell Biol. 2002 Mar;34(3):221-41.
    Hypericin in cancer treatment: more light on the way.[Pubmed: 11849990]
    Photodynamic therapy (PDT) has been described as a promising new modality for the treatment of cancer. PDT involves the combination of a photosensitizing agent (photosensitizer), which is preferentially taken up and retained by tumor cells, and visible light of a wavelength matching the absorption spectrum of the drug. Each of these factors is harmless by itself, but when combined they ultimately produce, in the presence of oxygen, cytotoxic products that cause irreversible cellular damage and tumor destruction. Hypericin, a powerful naturally occurring photosensitizer, is found in Hypericum perforatum plants, commonly known as St. John's wort. In recent years increased interest in hypericin as a potential clinical anticancer agent has arisen since several studies established its powerful in vivo and in vitro antineoplastic activity upon irradiation. Investigations of the molecular mechanisms underlying hypericin photocytotoxicity in cancer cells have revealed that this photosensitizer can induce both apoptosis and necrosis in a concentration and light dose-dependent fashion. Moreover, PDT with hypericin results in the activation of multiple pathways that can either promote or counteract the cell death program. This review focuses on the more recent advances in the use of hypericin as a photodynamic agent and discusses the current knowledge on the signaling pathways underlying its photocytotoxic action.
    J BUON. 2014 Jul-Sep;19(3):627-32.
    The effects of hypericin on ADAMTS and p53 gene expression in MCF-7 breast cancer cells.[Pubmed: 25261644]
    The purpose of this study was to determine the effects of hypericin on MCF-7 (Michigan Cancer Foundation- 7) breast cancer cells, as it is known to exert an antitumor effect on the expression and regulation of ADAMTS1, 3, 10 and the p53 gene in breast cancer cells.
    METHODS AND RESULTS:
    MFC-7 cells were cultured and subjected separately to various doses (1, 5 and 7.5 μg /mL) hypericin. After 24 hrs, RNA was isolated and transcribed into cDNA. Expression analysis was performed by real time (RT)-PCR and cell survival was determined by the XTT assay. While the expression of ADAMTS1 in MFC-7 cells decreased to 0.04-fold after exposure to 1 μg /mL hypericin, the expression increased by 5.6- and 36-fold with 5 and 7.5 μg/mL, respectively. Furthermore, ADAMTS3 expression in MCF7 cells increased 3.9-fold with the use of 5 μg /mL of hypericin. These concentrations of hypericin did not lead to significant changes in the expression of ADAMTS10 and the p53 gene. Viability of cancer cells as evaluated by the XTT assay showed that hypericin concentration of 7.5 μg /mL led to increased apoptosis of cancer cells.
    CONCLUSIONS:
    The increase in ADAMTS1 expression may prevent metastasis or facilitate the development of an adjuvant factor with tumor-suppressive effects. Hypericin may therefore exert its antitumor and apoptotic effects in MFC-7 cells via ADAMTS1 and ADAMTS3.
    Biochem. Biophys. Res. Commun., 1989 ,165(3):1207-12.
    Hypericin and pseudohypericin specifically inhibit protein kinase C: Possible relation to their antiretroviral activity[Pubmed: 2558652]
    Hypericin and pseudohypericin which have been isolated from plants of the Hypericum family are aromatic polycyclic diones. Daniel Meruelo et. al. have reported that hypericin and pseudohypericin showed potent antiretroviral activity including anti-human immunodeficiency virus (1,2). However, the mechanism of these antiretroviral activities has not been clarified.
    METHODS AND RESULTS:
    In the course of screening specific inhibitors of protein kinase C we have found that both compounds specifically inhibit protein kinase C with IC50 values 1.7 micrograms/ml and 15 micrograms/ml, respectively, and show antiproliferative activity against mammalian cells.
    CONCLUSIONS:
    These data suggest that antiretroviral activity of hypericin and pseudohypericin could be attributable to the inhibition of some phosphorylation involved by protein kinase C during viral infection of cells.
    In vivo:
    Planta Med. 1998 May;64(4):291-4.
    Solubilized hypericin and pseudohypericin from Hypericum perforatum exert antidepressant activity in the forced swimming test.[Pubmed: 9619107]

    METHODS AND RESULTS:
    It has been shown recently that the fraction IIIc of a crude extract of Hypericum perforatum, (St. John's wort) that contained both hypericin (1) and pseudohypericin (2), was remarkably active in the rats forced swimming test (FST) after Porsolt. However, neither of the naphthodianthrones isolated from this fraction were sufficiently effective when administered suspended in water. The solubility of 1 and 2 is remarkably increased in the presence of a fraction containing procyanidins, especially procyanidin B2, which is present also in the active Hypericum fraction IIIc. The cooperative effect of procyanidins significantly increased the in vivo effects of 1 and 2, which exhibited inverted U-shaped dose response curves, in the FST. The anti-immobility effect of solubilized 1 and 2 was antagonized by the dopamine antagonist sulpiride.
    CONCLUSIONS:
    These data indicate that naphthodianthrones are antidepressant constituents of H. perforatum and suggest that the dopaminergic system is involved in their action.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.9824 mL 9.9118 mL 19.8236 mL 39.6471 mL 49.5589 mL
    5 mM 0.3965 mL 1.9824 mL 3.9647 mL 7.9294 mL 9.9118 mL
    10 mM 0.1982 mL 0.9912 mL 1.9824 mL 3.9647 mL 4.9559 mL
    50 mM 0.0396 mL 0.1982 mL 0.3965 mL 0.7929 mL 0.9912 mL
    100 mM 0.0198 mL 0.0991 mL 0.1982 mL 0.3965 mL 0.4956 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    番泻苷元B; Sennidin B CFN99598 517-44-2 C30H18O10 = 538.46 5mg QQ客服:2159513211
    番泻苷A; Sennoside A CFN99903 81-27-6 C42H38O20 = 862.74 20mg QQ客服:1457312923
    番泻苷B; Sennoside B CFN99904 128-57-4 C42H38O20 = 862.74 20mg QQ客服:2159513211
    番泻苷C; Sennoside C CFN99905 37271-16-2 C42H40O19 = 848.76 10mg QQ客服:2159513211
    番泻苷D; Sennoside D CFN99906 37271-17-3 C42H40O19 = 848.76 5mg QQ客服:2056216494
    1,5,7'-联大黄素甲醚; Floribundone 1 CFN97845 118555-84-3 C32H22O10 = 566.52 5mg QQ客服:215959384
    原金丝桃素; Protohypericin CFN93055 548-03-8 C30H18O8 = 506.46 5mg QQ客服:215959384
    金丝桃素; Hypericin CFN99188 548-04-9 C30H16O8 = 504.45 20mg QQ客服:3257982914
    伪金丝桃素; Pseudohypericin CFN99591 55954-61-5 C30H16O9 = 520.44 5mg QQ客服:1413575084
    原伪金丝桃素; Protopseudohypericin CFN90677 54328-09-5 C30H18O9 = 522.46 10mg QQ客服:1413575084

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产