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  • 独活素

    Heraclenin

    独活素
    产品编号 CFN98354
    CAS编号 2880-49-1
    分子式 = 分子量 C16H14O5 = 286.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Coumarins
    植物来源 The fruits of Citrus aurantium L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    独活素 CFN98354 2880-49-1 1mg QQ客服:2056216494
    独活素 CFN98354 2880-49-1 5mg QQ客服:2056216494
    独活素 CFN98354 2880-49-1 10mg QQ客服:2056216494
    独活素 CFN98354 2880-49-1 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • VIT University (India)
  • Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)
  • Tohoku University (Japan)
  • Northeast Normal University Changchun (China)
  • University of Zurich (Switzerland)
  • China Medical University (Taiwan)
  • University of Stirling (United Kingdom)
  • University of Hull (United Kingdom)
  • Cancer Research Initatives Foundation(CARIF) (Malaysia)
  • University of Eastern Finland (Finland)
  • Heidelberg University (Germany)
  • University of Padjajaran (Indonesia)
  • Universite Libre de Bruxelles (Belgium)
  • Chulalongkorn University (Thailand)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Biochem Biophys Res Commun.2020, 527(4):889-895.
  • J Cell Biochem.2022, 123(7):1222-1236.
  • Sci Rep.2018, 8(1)
  • Front Immunol.2018, 9:2655
  • Korean J of Crop Science2019, 452-458
  • Biomed Chromatogr.2016, 30(10):1573-81
  • Plants (Basel).2022, 11(16):2126.
  • Phytother Res.2019, 33(7):1784-1793
  • J Adv Res.2021, 35:245-257.
  • Appl. Sci.2020, 10(23), 8729
  • Drug Des Devel Ther.2020, 14:61-71
  • An Acad Bras Cienc.2023, 95(3):e20220672
  • Industrial Crops and Products2022, 188:115596.
  • Int J Biol Macromol.2020, 161:1230-1239.
  • Molecules.2022, 27(7):2360.
  • Sci Rep.2021, 11(1):10931.
  • Biochem Biophys Res Commun.2018, 505(4):1148-1153
  • Mie University2019, 10076.
  • Molecules.2022, 27(21):7514.
  • J Cell Mol Med.2021, 25(5):2645-2654.
  • EXCLI J.2023, 22:482-498.
  • Evid Based Complement Alternat Med.2022, 2022:1307173.
  • Front Endocrinol (Lausanne).2020, 11:568436.
  • ...
  • 生物活性
    Description: Heraclenin has anticoagulant, and anti-inflammatory activities, it also has mutagenicity in Chlamydomonas reinhardii. Heraclenin can induce apoptosis in Jurkat leukemia cells, it has a strong clastogenic effect . (+)-Heraclenin displays significant levels of antiplasmodial and moderate levels of antimicrobial activities.
    Targets: Immunology & Inflammation related | Antifection
    In vitro:
    Mutat Res. 1986 Jan-Feb;169(1-2):51-4.
    Chromosome-damaging effects of heraclenin in human lymphocytes in vitro.[Pubmed: 3945237]

    METHODS AND RESULTS:
    Heraclenin, a furocoumarin with an epoxide group in its side chain, was analyzed to see if it induced structural chromosome aberrations and sister-chromatid exchanges (SCEs) in human lymphocytes in vitro. The results were compared directly with those of imperatorin, which differs from Heraclenin only in lacking an epoxide group. An equally strong clastogenic effect was found for both Heraclenin and imperatorin: the number of metaphases with breaks was increased in both cases by approximately a factor of 6. Heraclenin produced a considerable dose-dependent increase in the SCE rate, i.e., by about 60 induced SCEs/metaphase, whereas imperatorin induced only about 4 SCEs/metaphase.
    CONCLUSIONS:
    The results are discussed with respect to the occurrence of structural aberrations, which are primarily due to the basic furocoumarin structure itself, whereas the large increase in the SCE rate produced by Heraclenin is most probably significantly influenced by its epoxide group.
    Mutat Res. 1986 Jan-Feb;169(1-2):47-50.
    Mutagenicity of a furocoumarin epoxide, heraclenin, in Chlamydomonas reinhardii.[Pubmed: 3945236]
    Treatment of arg- or strd mutant cells of Chlamydomonas reinhardii with a furocoumarin epoxide, heraclenin, plus UV-A resulted in a decrease in survival and a UV-A dose-dependent increase in induced Arg+ or Strs revertants.
    METHODS AND RESULTS:
    Imperatorin, a furocoumarin with a very similar structure but lacking an epoxide group showed a very similar phototoxic and photomutagenic activity in these mutant strains. Treating the mutant cells with heraclenin or imperatorin in the dark neither influenced survival nor mutation induction. The results are discussed with respect to the involvement of the epoxide moiety of heraclenin in mutagenicity.
    Curr. Sci., 2011, 100(11):1706-11.
    Microbial transformation of (+)-heraclenin by Aspergillus niger and evaluation of its antiplasmodial and antimicrobial activities[Reference: WebLink]

    METHODS AND RESULTS:
    Microbial transformation of (+)-Heraclenin (1) by Aspergillus niger was studied in growth media to assess its antiplasmodial and antimicrobial activities. It was transformed to (-)-heraclenol (2) as the sole product in a stereospecific manner. The in vitro antiplasmodial activity of compounds 1 and 2 was tested with chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum. Further, the in vitro antibacterial activity of 1 and 2 against three Grampositive bacteria, Bacillus subtilis, Bacillus sphaericus and Staphylococcus aureus, and three Gram-negative bacteria, Pseudomonas aeruginosa, Escherichia coli and Chromobacterium violaceum was analysed using agar-plate diffusion assay. The same method was employed for the evaluation of antifungal activity against five pathogenic strains of fungi, A. niger, Rhizopus oryzae, Aspergillus flavus, Candida albicans and Saccharomyces cerevisiae.
    CONCLUSIONS:
    Both furanocoumarins 1 and 2 displayed significant levels of antiplasmodial and moderate levels of antimicrobial activities against the tested pathogenic strains. Compound 2 exhibited two-fold less potent antiplasmodial activity (IC50 = 6.0 μg/ml) than the parent compound 1 (IC50 = 2.5 μg/ml), whereas no difference was observed in the antimicrobial activity of both furanocoumarins. The oxirane ring was found to be beneficial in terms of antiplasmodial activity.
    In vivo:
    Planta Med. 2000 Apr;66(3):279-81.
    Anti-inflammatory activity of coumarins from Decatropis bicolor on TPA ear mice model.[Pubmed: 10821059]

    METHODS AND RESULTS:
    From the aerial parts of Decatropis bicolor, heraclenin (1), seselin (2), psoralen (3), imperatorin (4), skimmianine (5), and heraclenol (6), were isolated. This is the first time that coumarin-like compounds are isolated from Decatropis genus. The anti-inflammatory properties of compounds 1-6 were examined against the ear edema in mice produced by TPA.
    CONCLUSIONS:
    The results suggest that the anti-inflammatory activity of each compound depends of its individual substitution on the aromatic ring rather than the coumarin skeleton itself.
    Indian J Physiol Pharmacol. 1969 Jul;13(3):153-5.
    Anticoagulant activity of Heraclenin.[Pubmed: 5362630]

    METHODS AND RESULTS:
    Anticoagulant activity of Heraclenin.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.4928 mL 17.4642 mL 34.9284 mL 69.8568 mL 87.321 mL
    5 mM 0.6986 mL 3.4928 mL 6.9857 mL 13.9714 mL 17.4642 mL
    10 mM 0.3493 mL 1.7464 mL 3.4928 mL 6.9857 mL 8.7321 mL
    50 mM 0.0699 mL 0.3493 mL 0.6986 mL 1.3971 mL 1.7464 mL
    100 mM 0.0349 mL 0.1746 mL 0.3493 mL 0.6986 mL 0.8732 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    欧前胡素; Imperatorin CFN98758 482-44-0 C16H14O4 = 270.3 20mg QQ客服:2056216494
    独活素; Heraclenin CFN98354 2880-49-1 C16H14O5 = 286.3 5mg QQ客服:2056216494
    异栓翅芹醇; Isogosferol CFN98890 53319-52-1 C16H14O5 = 286.3 5mg QQ客服:1413575084
    异石当归素; Isosaxalin CFN98929 55481-86-2 C16H15ClO5 = 322.7 5mg QQ客服:2056216494
    白芷属脑; Heraclenol CFN98402 31575-93-6 C16H16O6 = 304.3 10mg QQ客服:2159513211
    (-)-白藏属脑; (-)-Heraclenol CFN89405 139079-42-8 C16H16O6 = 304.29 5mg QQ客服:3257982914
    独活属醇缩丙酮; Heraclenol acetonide CFN97112 64790-68-7 C19H20O6 = 344.4 5mg QQ客服:215959384
    3'-O-BETA-D-吡喃葡萄糖苷白芷属脑酯; Heraclenol 3'-O-beta-D-glucopyranoside CFN98410 32207-10-6 C22H26O11 = 466.4 5mg QQ客服:2056216494
    Heraclenol 3'-O-[beta-D-apiofuranosyl-(1-6)-beta-D-glucopyranoside]; Heraclenol 3'-O-[beta-D-apiofuranosyl-(1-6)-beta-D-glucopyranoside] CFN97243 765316-44-7 C27H34O15 = 598.6 5mg QQ客服:1413575084
    Rivulobirin E; Rivulobirin E CFN98247 237407-59-9 C32H30O11 = 590.6 5mg QQ客服:1457312923

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