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  • 4,2',4'-三羟基-6'-甲氧基查耳酮

    Helichrysetin

    4,2',4'-三羟基-6'-甲氧基查耳酮
    产品编号 CFN97065
    CAS编号 62014-87-3
    分子式 = 分子量 C16H14O5 = 286.3
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Chalcones
    植物来源 The fruits of Alpinia katsumadai Hayata.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    4,2',4'-三羟基-6'-甲氧基查耳酮 CFN97065 62014-87-3 1mg QQ客服:3257982914
    4,2',4'-三羟基-6'-甲氧基查耳酮 CFN97065 62014-87-3 5mg QQ客服:3257982914
    4,2',4'-三羟基-6'-甲氧基查耳酮 CFN97065 62014-87-3 10mg QQ客服:3257982914
    4,2',4'-三羟基-6'-甲氧基查耳酮 CFN97065 62014-87-3 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Mahatma Gandhi University (India)
  • Calcutta University (India)
  • Sant Gadge Baba Amravati University (India)
  • University of Hull (United Kingdom)
  • S.N.D.T. Women's University (India)
  • Universidade de Franca (Brazil)
  • Chinese University of Hong Kong (China)
  • Deutsches Krebsforschungszentrum (Germany)
  • University of Vienna (Austria)
  • Lund University (Sweden)
  • University of Oslo (Norway)
  • University of Brasilia (Brazil)
  • University of Dicle (Turkey)
  • Institute of Pathophysiology Medical University of Vienna (Austria)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Nutr Cancer.2023, 75(1):376-387.
  • Toxicol Rep.2021, 8:1131-1142.
  • Molecules.2022, 27(7):2093.
  • Trop J Nat Prod Res.2019, 3(1):6-9
  • Nutr Res Pract.2023, 17(4):670-681.
  • Int J Mol Sci.2017, 19(1)
  • Phytochem Anal.2013, 24(5):493-503
  • Mol Biol Rep.2022, doi: 10.1007
  • J Pharmaceut Biomed2020, 182:113110
  • Korean Journal of Pharmacognosy.2019, 50(1):65-71
  • Molecules.2019, 24(24),4583
  • J Food Sci Technol.2022, 59(1):212-219.
  • J. Pharm. Res. Int.2022, 34(58): pp.1-14.
  • Curr Issues Mol Biol.2022, 44(10):5106-5116.
  • Molecules.2021, 26(9):2765.
  • J Korean Soc Food Sci Nutr2020, doi: 10.3746.
  • Int J Biol Macromol.2018, 112:1093-1103
  • Sustainability2021, 13(23),12981.
  • Anal Chim Acta.2021, 1180:338874.
  • Plant Physiol Biochem.2019, 144:355-364
  • Chinese Medicine2019, 14(1)
  • Korean J. Medicinal Crop Sci.2022, 30(2):117-123.
  • J Ethnopharmacol.2019, 228:132-141
  • ...
  • 生物活性
    Description: Helichrysetin has mild anti-HIV-1 PR activity. Helichrysetin has great potentials for development as an anticancer agent, it has cytotoxic effect on four selected cancer cell lines, A549, MCF-7, Ca Ski, and HT-29.
    Targets: HIV
    In vitro:
    Bioorg Med Chem. 2006 Mar 15;14(6):1710-4.
    Anti-HIV-1 protease activity of compounds from Boesenbergia pandurata.[Pubmed: 16263298 ]

    METHODS AND RESULTS:
    Searching for anti-HIV-1 protease (PR) inhibitors of Thai medicinal plants led to the isolation of a new cyclohexenyl chalcone named panduratin C (1) and chalcone derivatives (2-6) from the methanol extract of Boesenbergia pandurata rhizomes. The known compounds were identified to be panduratin A (2), hydroxypanduratin A (3), Helichrysetin (4), 2',4',6'-trihydroxyhydrochalcone (5), and uvangoletin (6). The structures of all compounds were elucidated on the basis of chemical and spectroscopic methods. It was found that 3 possessed the most potent anti-HIV-1 PR activity with an IC50 value of 5.6 microM, followed by 2 (IC50 = 18.7 microM), whereas other compounds exhibited only mild activity.
    CONCLUSIONS:
    Structure-activity relationships of these compounds on anti-HIV-1 PR activity are summarized as follows: (1) hydroxyl moiety at position 4 conferred higher activity than methoxyl group; (2) prenylation of dihydrochalcone was essential for activity; (3) hydroxylation at position 4''' reduced activity; and (4) introduction of double bond at C1' and C6' of chalcone gave higher activity. As regards active constituents contained in B. pandurata rhizomes, hydroxypanduratin A (3) and panduratin A (2) are active principles against HIV-1 PR.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.4928 mL 17.4642 mL 34.9284 mL 69.8568 mL 87.321 mL
    5 mM 0.6986 mL 3.4928 mL 6.9857 mL 13.9714 mL 17.4642 mL
    10 mM 0.3493 mL 1.7464 mL 3.4928 mL 6.9857 mL 8.7321 mL
    50 mM 0.0699 mL 0.3493 mL 0.6986 mL 1.3971 mL 1.7464 mL
    100 mM 0.0349 mL 0.1746 mL 0.3493 mL 0.6986 mL 0.8732 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    3'-甲基-2',4'-二羟基-4,6'-二甲氧基查耳酮 ; 3'-Methyl-4-O-methylhelichrysetin CFN96164 109471-13-8 C18H18O5 = 314.3 5mg QQ客服:1457312923
    4,4'-二甲氧基查耳酮; 4,4'-Dimethoxychalcone CFN70472 2373-89-9 C17H16O3 = 268.3 5mg QQ客服:215959384
    异甘草素; 4,2',4'-三羟基查耳酮; Isoliquiritigenin CFN97542 961-29-5 C15H12O4 = 256.3 20mg QQ客服:1413575084
    2''-O-甲基异甘草苷元; 4,4'-二羟基-2'-甲氧基查耳酮; 2'-O-Methylisoliquiritigenin CFN98832 51828-10-5 C16H14O4 = 270.3 5mg QQ客服:1413575084
    3-去氧苏木查耳酮; 3-Deoxysappanchalcone CFN92833 112408-67-0 C16H14O4 = 270.3 5mg QQ客服:1413575084
    4,2'-Dihydroxy-4'-methoxychalcone ; 4,2'-Dihydroxy-4'-methoxychalcone CFN89427 63529-06-6 C16H14O4 = 270.28 5mg QQ客服:2056216494
    根皮素; Phloretin CFN97040 60-82-2 C15H14O5 = 274.3 20mg QQ客服:215959384
    4'-O-甲基根皮素 ; Asebogenin CFN96928 520-42-3 C16H16O5 = 288.29 5mg QQ客服:1413575084
    2',6'-二羟基-4,4'-二甲氧基二氢查耳酮; 2',6'-Dihydroxy 4',4-dimethoxydihydrochalcone CFN70345 35241-54-4 C17H18O5 = 302.3 5mg QQ客服:3257982914
    2-甲氧基根皮素; 2'-O-Methylphloretin (4,2',4'-Trihydroxy-6'-methoxydihydrochalcone) CFN91680 111316-17-7 C16H16O5 = 288.3 5mg QQ客服:2159513211

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