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  • 常春藤皂苷B

    Hederasaponin B

    常春藤皂苷B
    产品编号 CFN99986
    CAS编号 36284-77-2
    分子式 = 分子量 C59H96O25 = 1205.4
    产品纯度 >=98%
    物理属性 White powder
    化合物类型 Triterpenoids
    植物来源 The herbs of Hedera nepalensis
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    常春藤皂苷B CFN99986 36284-77-2 10mg QQ客服:215959384
    常春藤皂苷B CFN99986 36284-77-2 20mg QQ客服:215959384
    常春藤皂苷B CFN99986 36284-77-2 50mg QQ客服:215959384
    常春藤皂苷B CFN99986 36284-77-2 100mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Almansora University (Egypt)
  • Heidelberg University (Germany)
  • Technical University of Denmark (Denmark)
  • Medizinische Universit?t Wien (Austria)
  • University of Wuerzburg (Germany)
  • Universite de Lille1 (France)
  • University of Medicine and Pharmacy (Romania)
  • Macau University of Science and Technology (China)
  • National Research Council of Canada (Canada)
  • University of Zurich (Switzerland)
  • Julius Kühn-Institut (Germany)
  • Uniwersytet Medyczny w ?odzi (Poland)
  • Worcester Polytechnic Institute (USA)
  • Seoul National University of Science and Technology (Korea)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int J Mol Sci. 2014, 15(5):8443-57
  • Pharmacogn Mag.2015, 11:S585-91
  • J Basic Clin Physiol Pharmacol.2016, 27(1):1-8
  • J Agric Food Chem.2016, 64(35):6783-90
  • Nutrients.2017, 10(1)
  • Pharmacognosy Magazine2017, 13(52):868-874
  • Int J Mol Sci.2017, 19(1)
  • LWT-Food Science and Technology2017, 75:488-496
  • Front Aging Neurosci.2018, 10:269
  • Pharmacognosy Magazine2018, 14(56):418-424
  • J Sep Sci.2018, 41(7):1682-1690
  • Sci Rep. 2018, 462(8)
  • Korean J. Crop Sci.2018, 63(2):131-139
  • Front Pharmacol.2018, 9:756
  • Biorxiv2019, 10.1101
  • J of Essential Oil Research2019, 1677272
  • Life Sci.2019, 216:259-270
  • Molecules.2019, 24(17):E3127
  • J of Dentistry & Oral Health2019, 2641-1962
  • Pak J Pharm Sci.2019, 32(6)
  • Phytother Res.2019, 33(7):1784-1793
  • Phytomedicine.2019, 57:95-104
  • Pharmacological Reports2020, 1-9
  • ...
  • 生物活性
    Description: Hederasaponin B has antiviral activity, via inhibiting the viral VP2 protein expression and blocking viral capsid protein synthesis. It also has antitumor activity, and it inhibits the superoxide generation induced by arachidonic acid (AA).
    Targets: Antifection
    In vitro:
    Biomol Ther (Seoul). 2014 Jan;22(1):41-6.
    Antiviral Activity of Hederasaponin B from Hedera helix against Enterovirus 71 Subgenotypes C3 and C4a.[Pubmed: 24596620]
    Enterovirus 71 (EV71) is the predominant cause of hand, foot and mouth disease (HFMD). The antiviral activity of hederasaponin B from Hedera helix against EV71 subgenotypes C3 and C4a was evaluated in vero cells.
    METHODS AND RESULTS:
    In the current study, the antiviral activity of hederasaponin B against EV71 C3 and C4a was determined by cytopathic effect (CPE) reduction method and western blot assay. Our results demonstrated that hederasaponin B and 30% ethanol extract of Hedera helix containing hederasaponin B showed significant antiviral activity against EV71 subgenotypes C3 and C4a by reducing the formation of a visible CPE. Hederasaponin B also inhibited the viral VP2 protein expression, suggesting the inhibition of viral capsid protein synthesis.
    CONCLUSIONS:
    These results suggest that hederasaponin B and Hedera helix extract containing hederasaponin B can be novel drug candidates with broad-spectrum antiviral activity against various subgenotypes of EV71.
    J Asian Nat Prod Res. 2009;11(2):122-7.
    Triterpenoid saponins from Anemone flaccida induce apoptosis activity in HeLa cells.[Pubmed: 19219723]
    Five triterpenoid saponins were isolated from Anemone flaccida Fr. Schmidt. Their structures were identified as glycoside St-I4a (1), glycoside St-J (2), anhuienoside E (3), hederasaponin B (4), and flaccidoside II (5). Compounds 1-2 were isolated from Anemone family for the first time, and compounds 3-4 were isolated from this plant for the first time.
    METHODS AND RESULTS:
    The inhibitory effects of saponins on proliferation of HeLa cells were studied by MTT assay, the apoptosis-induction activity was observed by cell-cycle analysis and caspase-3 expression assay. The antitumor activities of the saponins were ranked in the following order: 5 > 3 > 4 > 1 > 2.
    CONCLUSIONS:
    The data presented here indicated that naturally occurring triterpenoid saponins can be regarded as excellent structures for the potential development of new anticancer agents.
    Fitoterapia. 2009 Mar;80(2):105-11.
    Antiperoxidation activity of triterpenoids from rhizome of Anemone raddeana.[Pubmed: 19084054]
    Four triterpenoid compounds hederacolchiside E (1), hederasaponin B (2), raddeanoside 20 (3) and raddeanoside 21 (4) were isolated from ethanol extracts of rhizome of Anemone raddeana Regel.
    METHODS AND RESULTS:
    The effects of these triterpenoids on superoxide generation, tyrosyl phosphorylation of proteins and translocation of cytosolic compounds, such as p47(phox), p67(phox) and Rac to the cell membrane in human neutrophils was investigated. The superoxide generation induced by N-formyl-methionyl-leucyl-phenylalanine (fMLP) was slightly suppressed by hederasaponin B, raddeanoside 20 and raddeanoside 21 in a concentration dependent manner. The superoxide generation induced by arachidonic acid (AA) was suppressed by hederasaponin B and raddeanoside 21 significantly.
    CONCLUSIONS:
    fMLP- and AA-induced tyrosyl phosphorylation and translocation of the cytosolic proteins: p47(phox), p67(phox), and Rac to the cell membrane were suppressed in parallel with the suppression of stimulus-induced superoxide generation.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 0.8296 mL 4.148 mL 8.296 mL 16.592 mL 20.74 mL
    5 mM 0.1659 mL 0.8296 mL 1.6592 mL 3.3184 mL 4.148 mL
    10 mM 0.083 mL 0.4148 mL 0.8296 mL 1.6592 mL 2.074 mL
    50 mM 0.0166 mL 0.083 mL 0.1659 mL 0.3318 mL 0.4148 mL
    100 mM 0.0083 mL 0.0415 mL 0.083 mL 0.1659 mL 0.2074 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    龙牙楤木皂甙VII; Tarasaponin VII CFN90543 144118-18-3 C52H84O21 = 1045.22 5mg QQ客服:2159513211
    辽东楤木皂苷V; Araloside V CFN90322 340963-86-2 C54H88O23 = 1105.3 20mg QQ客服:1148253675
    辽东楤木皂苷X; Araloside X CFN90323 344911-90-6 C60H98O28 = 1267.42 20mg QQ客服:3257982914
    常春藤皂苷B; Hederasaponin B CFN99986 36284-77-2 C59H96O25 = 1205.4 20mg QQ客服:215959384
    Acanthopanaxoside B; Acanthopanaxoside B CFN93301 915792-03-9 C61H98O27 = 1263.43 5mg QQ客服:1148253675
    红背银莲花皂甙R8; Raddeanoside R8 CFN94832 124961-61-1 C65H106O30 = 1367.54 5mg QQ客服:1148253675
    Clematichinenoside C; Clematichinenoside C CFN90971 177912-24-2 C70H114O34 = 1499.65 5mg QQ客服:2932563308
    白头翁皂苷E3; Pulchinenoside E3 CFN80363 824401-07-2 C71H116O35 = 1529.66 5mg QQ客服:2932563308
    Clematiunicinoside E; Clematiunicinoside E CFN90903 916649-92-8 C76H124O39 = 1661.79 5mg QQ客服:2159513211
    Clematomandshurica saponin B; Clematomandshurica saponin B CFN90904 916649-91-7 C92H142O46 = 1984.10 5mg QQ客服:2159513211

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