Info: Read More
  • 中药标准品生产商,产品定制服务
  • 鸟嘌呤核苷

    Guanosine

    鸟嘌呤核苷
    产品编号 CFN90925
    CAS编号 118-00-3
    分子式 = 分子量 C10H13N5O5 = 283.2
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The peels of Punica granatum L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    鸟嘌呤核苷 CFN90925 118-00-3 10mg QQ客服:1457312923
    鸟嘌呤核苷 CFN90925 118-00-3 20mg QQ客服:1457312923
    鸟嘌呤核苷 CFN90925 118-00-3 50mg QQ客服:1457312923
    鸟嘌呤核苷 CFN90925 118-00-3 100mg QQ客服:1457312923
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Subang Jaya Medical Centre (Malaysia)
  • Mendel University in Brno (Czech Republic)
  • S.N.D.T. Women's University (India)
  • Universiti Kebangsaan Malaysia (Malaysia)
  • University of Maryland (USA)
  • Universidade Católica Portuguesa (Portugal)
  • Center for protein Engineering (CIP) (Belgium)
  • Universitas islam negeri Jakarta (Indonesia)
  • University of Medicine and Pharmacy (Romania)
  • Leibniz Institute of Plant Biochemistry (Germany)
  • Universidade Federal de Goias (UFG) (Brazil)
  • University of Padjajaran (Indonesia)
  • University of Illinois (USA)
  • Universidade da Beira Interior (Germany)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Cell Mol Med.2018, 22(9):4236-4242
  • Food Chem.2019, 290:286-294
  • The Journal of Korean Medicine2022, 43(3): 79-93.
  • Molecules.2017, 22(12)
  • Int J Oncol.2019, 55(1):320-330
  • Phytomedicine.2019, 57:95-104
  • Molecules.2022, 27(22):7997.
  • TCI CO.2019, US20190151257A1
  • J Ethnopharmacol.2017, 198:205-213
  • Mediators Inflamm. 2016, 2016:6189590
  • Int Immunopharmacol.2021, 101(Pt A):108181.
  • J Appl Biol Chem2022, 65:343−348.
  • Metab Eng.2022, 75:143-152.
  • Cancers (Basel).2021, 13(9):2223.
  • Nutrients2022, 14(14)2929
  • J Agric Food Chem.2021, 69(14):4210-4222.
  • Korean Journal of Pharmacognosy.2015, 46(4):352-364
  • Nat Chem Biol.2018, 14(8):760-763
  • Preprints2022, 2022030063.
  • Curr Eye Res.2018, 43(1):27-34
  • Food Sci Biotechnol.2023, 32(9):1215-1223.
  • Processes2021, 9(1), 153.
  • Phytomedicine.2018, 38:45-56
  • ...
  • 生物活性
    Description: Guanosine and GMP show anticonvulsant properties, which may be related with antagonism of glutamate receptors; they also prevent seizures induced by quinolinic acid in mice.Guanosine protects against renal ischemic injury by replenishing GTP stores and preventing tubular apoptosis.
    Targets: GABA Receptor
    In vivo:
    Brain Res. 2000 May 2;864(1):40-3.
    Guanosine and GMP prevent seizures induced by quinolinic acid in mice.[Pubmed: 10793184]
    In the mammalian CNS, glutamate and GABA are the principal neurotransmitters mediating excitatory and inhibitory synaptic events, respectively, and have been implicated in the neurobiology of seizures. Guanine-based purines, including the nucleoside guanosine and the nucleotide GMP, have been shown to antagonize glutamatergic activity at the receptor level and the other purine nucleoside adenosine is a well-known modulator of seizure threshold.
    CONCLUSIONS:
    In the present study we investigated the anticonvulsant effect of i. p. guanosine and GMP against seizures induced by the glutamate agonist quinolinic acid (QA) or the GABA(A) antagonist picrotoxin in mice. Animals were pretreated with an i.p. injection of saline, guanosine or GMP 30 min before either an i.c.v. injection of 4 microliter QA (36.8 nmol) or a subcutaneous injection of picrotoxin (3.2 mg/kg). All animals pretreated with vehicle followed by QA or picrotoxin presented seizures, which were completely prevented by the NMDA antagonist MK-801 and the GABA agonist phenobarbital, respectively. Guanosine and GMP dose-dependently protected against QA-induced seizures, up to 70 and 80% at 7.5 mg/kg, with ED(50)=2. 6+/-0.4 and 1.7+/-0.6 mg/kg, respectively. Conversely, neither guanosine, GMP nor MK-801 affected picrotoxin-induced seizures, indicating some degree of specificity towards the glutamatergic system.
    CONCLUSIONS:
    This study suggests anticonvulsant properties of i.p. guanosine and GMP, which may be related with antagonism of glutamate receptors.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.5311 mL 17.6554 mL 35.3107 mL 70.6215 mL 88.2768 mL
    5 mM 0.7062 mL 3.5311 mL 7.0621 mL 14.1243 mL 17.6554 mL
    10 mM 0.3531 mL 1.7655 mL 3.5311 mL 7.0621 mL 8.8277 mL
    50 mM 0.0706 mL 0.3531 mL 0.7062 mL 1.4124 mL 1.7655 mL
    100 mM 0.0353 mL 0.1766 mL 0.3531 mL 0.7062 mL 0.8828 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    3-甲基黄嘌呤; 3-Methylxanthine CFN95087 1076-22-8 C6H6N4O2 = 166.1 20mg QQ客服:215959384
    可可碱; Theobromine CFN99737 83-67-0 C7H8N4O2 = 180.16 20mg QQ客服:2056216494
    茶碱; Theophylline CFN99768 58-55-9 C7H8N4O2 = 180.16 20mg QQ客服:1413575084
    腺嘌呤; Adenine CFN89041 73-24-5 C5H5N5 = 135.13 20mg QQ客服:1413575084
    S-(5'-腺苷基)-L-氯化蛋氨酸; S-(5'-Adenosyl)-L-methionine chloride CFN90073 24346-00-7 C15H23ClN6O5S = 434.9 10mg QQ客服:3257982914
    S-腺甙甲硫氨酸对甲苯磺酸盐; S-Adenosyl-L-methionine tosylate CFN90074 71914-80-2 C22H30N6O8S2 = 570.6 5mg QQ客服:1413575084
    S-腺苷蛋氨酸; S-Adenosyl-L-Methtonine CFN90075 17176-17-9 C15H22N6O5S = 398.44 20mg QQ客服:215959384
    S-腺苷基-L-蛋氨碘盐; S-Adenosyl-L-Methionine iodide salt CFN90076 3493-13-8 C15H23IN6O5S.I = 526.3 5mg QQ客服:1413575084
    Zarzissine; Zarzissine CFN96195 160568-14-9 C5H5N5 = 135.1 5mg QQ客服:3257982914
    鸟嘌呤核苷; Guanosine CFN90925 118-00-3 C10H13N5O5 = 283.2 20mg QQ客服:215959384

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产