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  • 粘霉烯乙酸酯

    Glutinol acetate

    粘霉烯乙酸酯
    产品编号 CFN96385
    CAS编号 6426-44-4
    分子式 = 分子量 C32H52O2 = 468.8
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The stems and leaves of Acer mandshuricum.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    粘霉烯乙酸酯 CFN96385 6426-44-4 1mg QQ客服:1457312923
    粘霉烯乙酸酯 CFN96385 6426-44-4 5mg QQ客服:1457312923
    粘霉烯乙酸酯 CFN96385 6426-44-4 10mg QQ客服:1457312923
    粘霉烯乙酸酯 CFN96385 6426-44-4 20mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Brasilia (Brazil)
  • Michigan State University (USA)
  • Shanghai Institute of Organic Chemistry (China)
  • Nanjing University of Chinese Medicine (China)
  • Utah State University (USA)
  • University of Virginia (USA)
  • Universidad Veracuzana (Mexico)
  • University of Padjajaran (Indonesia)
  • Seoul National University (Korea)
  • Warszawski Uniwersytet Medyczny (Poland)
  • Yale University (USA)
  • University of Parma (Italy)
  • Chungnam National University (Korea)
  • Deutsches Krebsforschungszentrum (Germany)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Antiviral Res.2021, 193:105142.
  • J Pharm Biomed Anal.2019, 164:119-127
  • Food Chemistry: X.2022, 2022.100270
  • Pest Manag Sci.2023, 79(8):2675-2685.
  • Sci Rep.2023, 13(1):21690.
  • Int J Mol Sci.2017, 18(12)
  • Front Pharmacol.2017, 8:673
  • Appl Microbiol Biotechnol.2016, 100(9):3965-77
  • Anal Biochem.2019, 569:10-15
  • J Cell Mol Med.2023, 27(10):1423-1435.
  • J Liq Chromatogr R T2018, 41(12):761-769
  • Pak J Pharm Sci.2019, 32(6):2879-2885
  • Inflammation2015, 38(1):445-55
  • Molecules.2019, 24(19):E3417
  • Journal of Functional Foods2019, 52:430-441
  • Industrial Crops and Products2022, 186:115298
  • Sci Rep.2016, 6:25094
  • Nat Chem Biol.2018, 14(8):760-763
  • UDC.2020, 19(4).
  • Int J Mol Sci.2019, 20(11):E2734
  • Antioxidants (Basel).2022, 11(10):1929.
  • Natural Product Communications2020, doi: 10.1177.
  • Molecules.2021, 26(18):5665.
  • ...
  • 生物活性
    Description: Glutinol acetate shows significant cytotoxic activity against four human cancer cell lines (HL-60, SK-OV-3, A549, and HT-29), with GI(50) in the range of 11.1-17.9microM; it also has anti-inflammatory effect, exhibits moderate inhibitory activity of TNF-alpha secretion in the lipopolysaccharide (LPS)-stimulated murine RAW264.7 macrophage cell line.
    Targets: TNF-α
    In vitro:
    Bioorg Med Chem Lett. 2010 Mar 1;20(5):1528-31
    Triterpene compounds isolated from Acer mandshuricum and their anti-inflammatory activity.[Pubmed: 20153184 ]
    In our preliminary screening study on the anti-inflammatory activity, a new triterpene compound, aceranol acetate (1), was isolated along with five known compounds: beta-amyrin acetate (2); Glutinol acetate (3); friedelin (4); glutinol (5); (3beta)-d-glucopyranoside-stigmast-5-en-3-yl (6), from the stems and leaves of Acer mandshuricum.
    METHODS AND RESULTS:
    The structure of the new triterpene was determined to be 5alpha,6alpha-epidioxy-5beta,6beta-epoxy-9,13-dimethyl-25,26-dinoroleanan-3beta-ol acetate by spectroscopic studies. Compounds 2-6 were isolated from this plant for the first. Five triterpene compounds (1-5) showed significant cytotoxic activity with GI(50) in the range of 11.1-17.9microM, whereas steroid compound (6) exhibited moderate activity against four human cancer cell lines (HL-60, SK-OV-3, A549, and HT-29). Furthermore, the anti-inflammatory effects of compounds 1-6 in the non-cytotoxic concentrations (1-100nM) were evaluated for the inhibitory activity of TNF-alpha secretion in the lipopolysaccharide (LPS)-stimulated murine RAW264.7 macrophage cell line.
    CONCLUSIONS:
    Among the compounds tested, compound 2 showed the strongest anti-inflammatory activity with the inhibition rate up to 38.40% at the concentration of 100nM, whereas other five compounds (2-6) exhibited moderate activity.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1331 mL 10.6655 mL 21.3311 mL 42.6621 mL 53.3276 mL
    5 mM 0.4266 mL 2.1331 mL 4.2662 mL 8.5324 mL 10.6655 mL
    10 mM 0.2133 mL 1.0666 mL 2.1331 mL 4.2662 mL 5.3328 mL
    50 mM 0.0427 mL 0.2133 mL 0.4266 mL 0.8532 mL 1.0666 mL
    100 mM 0.0213 mL 0.1067 mL 0.2133 mL 0.4266 mL 0.5333 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    5-麦谷蛋白-3-醇; 5-Glutinen-3-ol CFN98911 545-24-4 C30H50O = 426.7 5mg QQ客服:1413575084
    粘霉烯乙酸酯; Glutinol acetate CFN96385 6426-44-4 C32H52O2 = 468.8 5mg QQ客服:2056216494
    黏黴酮; Glutinone CFN98802 508-09-8 C30H48O = 424.7 5mg QQ客服:2056216494
    栝楼萜二醇; Karounidiol CFN90563 118117-31-0 C30H48O2 = 440.7 5mg QQ客服:1413575084
    Bryonolol; Bryonolol CFN90562 39765-50-9 C30H50O2 = 442.7 5mg QQ客服:215959384
    绿舒筋酮; Mupinensisone CFN97818 152253-67-3 C30H48O2 = 440.71 5mg QQ客服:1413575084
    3,29-二苯甲酰基栝楼仁三醇; 3,29-Dibenzoyl karounitriol CFN90576 873001-54-8 C44H58O5 = 666.94 20mg QQ客服:3257982914
    3,29-二苯甲酰基栝楼仁二醇; 3,29-O-Dibenzoyloxykarounidiol CFN91175 389122-01-4 C44H56O4 = 648.9 10mg QQ客服:215959384
    Friedelin 3,4-lactone; Friedelin 3,4-lactone CFN89057 29621-75-8 C30H50O2 = 442.72 5mg QQ客服:3257982914

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