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  • 光甘草酮

    Glabrone

    光甘草酮
    产品编号 CFN93041
    CAS编号 60008-02-8
    分子式 = 分子量 C20H16O5 = 336.34
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The herbs of Cudrania tricuspidata
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    光甘草酮 CFN93041 60008-02-8 1mg QQ客服:2159513211
    光甘草酮 CFN93041 60008-02-8 5mg QQ客服:2159513211
    光甘草酮 CFN93041 60008-02-8 10mg QQ客服:2159513211
    光甘草酮 CFN93041 60008-02-8 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Shanghai Institute of Organic Chemistry (China)
  • University Medical Center Mainz (Germany)
  • University of Dicle (Turkey)
  • Siksha O Anusandhan University (India)
  • University of Helsinki (Finland)
  • Medical University of Gdansk (Poland)
  • University of Virginia (USA)
  • Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)
  • Griffith University (Australia)
  • Shanghai University of TCM (China)
  • Uniwersytet Gdański (Poland)
  • Max-Planck-Insitut (Germany)
  • Florida International University (USA)
  • University of Maryland (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Biomol Struct Dyn.2022, 5;1-17.
  • J Nat Med.2017, 71(2):457-462
  • J of Food Quality2020, 8851285.
  • Nat Chem Biol.2018, 14(8):760-763
  • Anal Chim Acta.2018, 1039:162-171
  • J Control Release.2021, 336:159-168.
  • Molecules.2021, 26(9):2802.
  • Evid Based Complement Alternat Med.2022, 9767292,2.
  • J Sci Food Agric.2017, 97(5):1656-1662
  • Applied Biological Chemistry2022, 65(12)
  • Nutrients2020, 12(3):811.
  • Separation Science Plus2022, sscp.202200048.
  • Molecules.2019, 24(16):E3003
  • Sci Rep.2019, 9:19059
  • Int J Biol Macromol.2018, 112:1093-1103
  • Indian J Pharm Sci.2022, 84(4): 874-882.
  • Molecules.2022, 27(13):4227.
  • Oncotarget.2017, 8(64):108006-108019
  • Clin Transl Med.2021, 11(5):e392.
  • Phytochemistry Letters2021, 43:80-87.
  • Evid-Based Compl Alt2020, 7202519:13
  • Am J Chin Med.2016, 44(6):1255-1271
  • Oncol Rep.2021, 46(1):143.
  • ...
  • 生物活性
    Description: Glabrone shows antiviral activity against influenza virus. It also exhibits significant PPAR-gamma ligand-binding activity.
    Targets: Influenza virus | PPAR
    In vitro:
    J Nat Prod. 2014 Mar 28;77(3):563-70.
    Computer-guided approach to access the anti-influenza activity of licorice constituents.[Pubmed: 24313801]
    Neuraminidase (NA), a key enzyme in viral replication, is the first-line drug target to combat influenza.
    METHODS AND RESULTS:
    On the basis of a shape-focused virtual screening, the roots of Glycyrrhiza glabra (licorice) were identified as plant species with an accumulation of constituents that show 3D similarities to known influenza NA inhibitors (NAIs). Phytochemical investigation revealed 12 constituents identified as (E)-1-[2,4-dihydroxy-3-(3-methyl-2-butenyl)phenyl]-3-(8-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-2-propen-1-one (1), 3,4-dihydro-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b']dipyran-3-ol (2), biochanin B (3), glabrol (4), Glabrone (5), hispaglabridin B (6), licoflavone B (7), licorice glycoside B (8), licorice glycoside E (9), liquiritigenin (10), liquiritin (11), and prunin (12). Eleven of these constituents showed significant influenza virus NA inhibition in a chemiluminescence (CL)-based assay. Additional tests, including (i) a cell-based cytopathic effect inhibition assay (general antiviral activity), (ii) the evaluation of cytotoxicity, (iii) the inhibition of the NA of Clostridium perfringens (CL- and fluorescence (FL)-based assay), and (iv) the determination of self-fluorescence and quenching, provided further perspective on their anti-influenza virus potential, revealing possible assay interference problems and false-positive results.
    CONCLUSIONS:
    Compounds 1, 3, 5, and 6 showed antiviral activity, most likely caused by the inhibition of NA. Of these, compounds 1, 3, and 6 were highly ranked in shape-focused virtual screening.
    Bioorg Med Chem. 2010 Jan 15;18(2):962-70.
    Phenolics from Glycyrrhiza glabra roots and their PPAR-gamma ligand-binding activity.[Pubmed: 20022509 ]

    METHODS AND RESULTS:
    Bioassay-guided fractionation of the EtOH extract of licorice (Glycyrrhiza glabra roots), using a GAL-4-PPAR-gamma chimera assay method, resulted in the isolation of 39 phenolics, including 10 new compounds (1-10). The structures of the new compounds were determined by analysis of their spectroscopic data. Among the isolated compounds, 5'-formylglabridin (5), (2R,3R)-3,4',7-trihydroxy-3'-prenylflavane (7), echinatin, (3R)-2',3',7-trihydroxy-4'-methoxyisoflavan, kanzonol X, kanzonol W, shinpterocarpin, licoflavanone A, glabrol, shinflavanone, gancaonin L, and Glabrone all exhibited significant PPAR-gamma ligand-binding activity.
    CONCLUSIONS:
    The activity of these compounds at a sample concentration of 10microg/mL was three times more potent than that of 0.5microM troglitazone.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.9732 mL 14.8659 mL 29.7318 mL 59.4636 mL 74.3295 mL
    5 mM 0.5946 mL 2.9732 mL 5.9464 mL 11.8927 mL 14.8659 mL
    10 mM 0.2973 mL 1.4866 mL 2.9732 mL 5.9464 mL 7.433 mL
    50 mM 0.0595 mL 0.2973 mL 0.5946 mL 1.1893 mL 1.4866 mL
    100 mM 0.0297 mL 0.1487 mL 0.2973 mL 0.5946 mL 0.7433 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    甘草瑞酮; Glicoricone CFN95063 161099-37-2 C21H20O6 = 368.4 5mg QQ客服:2056216494
    甘草利酮; Licoricone CFN96504 51847-92-8 C22H22O6 = 382.41 5mg QQ客服:2056216494
    异新补骨脂异黄酮; Isoneobavaisoflavone CFN92223 40357-43-5 C20H18O4 = 322.4 5mg QQ客服:2159513211
    光甘草酮; Glabrone CFN93041 60008-02-8 C20H16O5 = 336.34 5mg QQ客服:3257982914
    新补骨脂异黄酮; Neobavaisoflavone CFN92222 41060-15-5 C20H18O4 = 322.4 20mg QQ客服:2056216494
    3'-二甲基烯丙基染料木黄酮; Isowighteone CFN97166 68436-47-5 C20H18O5 = 338.4 5mg QQ客服:2159513211
    Isoderrone; Isoderrone CFN92794 121747-89-5 C20H16O5 = 336.3 5mg QQ客服:2056216494
    黄甘草异黄酮A; Eurycarpin A CFN97806 166547-20-2 C20H18O5 = 338.36 5mg QQ客服:2056216494
    甘草异黄酮A; Licoisoflavone A CFN90816 66056-19-7 C20H18O6 = 354.4 5mg QQ客服:3257982914
    甘草异黄酮 B; Licoisoflavone B CFN96405 66056-30-2 C20H16O6 = 352.4 5mg QQ客服:215959384

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