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  • 人参皂苷Ro

    Ginsenoside Ro

    人参皂苷Ro
    产品编号 CFN99147
    CAS编号 34367-04-9
    分子式 = 分子量 C48H76O19 = 957.11
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The roots of Panax ginseng C. A. Mey.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    人参皂苷Ro CFN99147 34367-04-9 10mg QQ客服:2159513211
    人参皂苷Ro CFN99147 34367-04-9 20mg QQ客服:2159513211
    人参皂苷Ro CFN99147 34367-04-9 50mg QQ客服:2159513211
    人参皂苷Ro CFN99147 34367-04-9 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Georgia Institute of Technology (USA)
  • Heidelberg University (Germany)
  • Mahidol University (Thailand)
  • The University of Newcastle (Australia)
  • University of Hull (United Kingdom)
  • St. Jude Children Research Hospital (USA)
  • Charles Sturt University (Denmark)
  • Subang Jaya Medical Centre (Malaysia)
  • Texas A&M University (USA)
  • Instituto Politécnico de Bragan?a (Portugal)
  • Monash University (Australia)
  • University of Stirling (United Kingdom)
  • Monash University Malaysia (Malaysia)
  • University of Cincinnati (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Front Pharmacol.2022, 13:906763.
  • Biomol Ther (Seoul).2020, 28(6):542-548.
  • Natural Product Communications2020, doi: 10.1177.
  • Appl. Sci. 2021, 11(8),3437.
  • Food Research International2016, 106-113
  • J Int Med Res.2021, 49(7):3000605211032849.
  • Int J Mol Sci.2019, 20(3):E651
  • Food Chem.2019, 275:746-753
  • Toxins (Basel).2021, 13(12):898.
  • Int Immunopharmacol.2021, 100:108073.
  • In Vitro Cellular & Developmental Biology - Plant2022, 58:972-988.
  • Pest Manag Sci.2019, 75(9):2530-2541
  • FASEB J.2019, 33(2):2026-2036
  • J Pharmaceut Biomed2020, 178:112894
  • Nutrients.2018, 10(7)
  • Plant Growth Regulation2020, 90(2):383-392
  • Exp Parasitol.2015, 153:160-4
  • J Korean Med Ophthalmol Otolaryngol Dermatol2023, 36(1):1-20.
  • Industrial Crops and Products2022, 186:115298
  • Cell Physiol Biochem.2017, 43(4):1425-1435
  • Preprints2022, 202211.0388.v1.
  • Neurotoxicology.2022, 91:218-227.
  • Mol Plant Pathol.2022, 10.1111:mpp.13280.
  • ...
  • 生物活性
    Description: Ginsenoside Ro has antioxidative properties against UV-B-induced oxidative stress in human dermal fibroblasts, it possesses a potential skin anti-photoaging property against UV-B radiation in fibroblasts. It also exerts anti-apoptosis and anti-inflammation in IL-1β-induced rat chondrocytes, which might be related to NF-κB signal pathway, it might be a potential novel drug for the treatment of osteoarthritis. Ginsenoside Ro enhances in vivo hair re-growth based on their inhibitory activity against 5αR in the androgenetic alopecia model, it shows immunomodulatory effects by regulating the production and expression of Th1/Th2 cytokines in murine splenocytes.
    Targets: Bcl-2/Bax | p53 | IL Receptor | Caspase | NF-kB | MMP(e.g.TIMP) | COX | ROS
    In vitro:
    Biosci Biotechnol Biochem. 2015;79(12):2018-21.
    Antioxidative properties of ginsenoside Ro against UV-B-induced oxidative stress in human dermal fibroblasts.[Pubmed: 26214051]
    Ginsenoside Ro (Ro), an oleanolic acid-type ginsenoside, exhibited suppressive activities on reactive oxygen species (ROS) and matrix metalloproteinase-2 (MMP-2) elevation in UV-B-irradiated fibroblasts. Ro could overcome the reduction of the total glutathione (GSH) contents in UV-B-irradiated fibroblasts. Ro could not interfere with cell viabilities in UV-B-irradiated fibroblasts. Collectively, Ro possesses a potential skin anti-photoaging property against UV-B radiation in fibroblasts.
    In vivo:
    Planta Med. 1991 Dec;57(6):523-6.
    Anti-hepatitic activity of ginsenoside Ro.[Pubmed: 1818342]
    Ginsenoside Ro, an oleanane-type saponin has been screened for activity in experimental models of acute and chronic hepatitis.
    METHODS AND RESULTS:
    Ginsenoside Ro (50 and 200 mg/kg, p.o.) inhibited the increase of serum glutamic oxaloacetic transaminase (s-GOT) and serum glutamic pyruvic transaminase (s-GPT) levels in D-galactosamine (GalN)- and carbon tetrachloride (CCl4)-induced acute hepatitic rats. Ginsenoside Ro inhibited the increase of connective tissue in the liver of CCl4-induced chronic hepatitic rats.
    CONCLUSIONS:
    Ginsenoside Ro showed a stronger inhibitory effect on the GalN-induced acute hepatitic model than those of the aglycone of ginsenoside Ro, oleanolic acid, or glycyrrhizic acid and its aglycone, glycyrrhetinic acid.
    Planta Med. 1990 Feb;56(1):19-23.
    Anti-inflammatory activity of ginsenoside ro.[Pubmed: 17221369]
    Ginsenoside Ro, an oleanane-type saponin has been screened for activity in experimental models of inflammation.
    METHODS AND RESULTS:
    Ginsenoside Ro (10,50, and 200 mg/kg, P. O.) inhibited an increase in vascular permeability in mice induced by acetic acid and reduced an acute paw edema in rats induced by compound 48/80 or carrageenin.
    CONCLUSIONS:
    Ginsenoside Ro did not suppress a developing adjuvant-induced edema in arthritic rats. However, ginsenoside Ro was found to be effective in hypercoagulable state, increase of connective tissue in the artery and calcium effluence from the bone in adjuvant-induced arthritic rats.
    Sci Rep . 2017 Jun 20;7(1):3888.
    The traditional Chinese medicine Achyranthes bidentata and our de novo conception of its metastatic chemoprevention: from phytochemistry to pharmacology[Pubmed: 28634392]
    Abstract Our recent biosystems analysis revealed similarities between embryonic implantation and cancer cell adhesion, which suggests that abortifacients may be good for safe and effective metastatic chemoprevention targeting circulating tumor cells (CTC). Here we test the hypothesis by using the well-known abortion herb Achyranthes bidentata Blume (A. bidentata). Five compounds were separated from the herb root. Among them, ginsenoside Ro was the most potent in inhibiting embryonic implantation within non-cytotoxic concentrations. It specifically inhibited the metastatic dissemination capability of colon cancer cells HT29, including the migration and invasion ability, and their adhesion to human endothelium through inhibiting integrin αvβ6, MMP-2, MMP-9, and ERK phosphorylation by HT29. Pretreatment of nude mice with oral ginsenoside Ro followed by HT29 intravenous inoculation and 40-day oral ginsenoside Ro significantly prevented lung metastasis with downregulation of integrin αvβ6 and no toxicity. The present study firstly introduces the new conception of utilizing safe and effective abortion botanic medicines for CTC-based metastatic chemoprevention.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.0448 mL 5.2241 mL 10.4481 mL 20.8962 mL 26.1203 mL
    5 mM 0.209 mL 1.0448 mL 2.0896 mL 4.1792 mL 5.2241 mL
    10 mM 0.1045 mL 0.5224 mL 1.0448 mL 2.0896 mL 2.612 mL
    50 mM 0.0209 mL 0.1045 mL 0.209 mL 0.4179 mL 0.5224 mL
    100 mM 0.0104 mL 0.0522 mL 0.1045 mL 0.209 mL 0.2612 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    常春藤皂苷元 28-O-beta-D-吡喃葡萄糖酯; Hederagenin 28-O-beta-D-glucopyranosyl ester CFN90651 53931-25-2 C36H58O9 = 634.9 10mg QQ客服:1457312923
    Arjunglucoside II; Arjunglucoside II CFN89144 62369-72-6 C36H58O10 = 650.85 5mg QQ客服:1413575084
    泰国树脂酸-28-O-β-D-葡萄糖酯苷; Siaresinolic acid 28-O-beta-D-glucopyranosyl ester CFN91847 155653-86-4 C36H58O9 = 634.9 5mg QQ客服:1413575084
    Arjunetin; Arjunetin CFN91151 31297-79-7 C36H58O10 = 650.9 5mg QQ客服:1457312923
    Arjunglucoside I; Arjunglucoside I CFN95049 62319-70-4 C36H58O11 = 666.9 10mg QQ客服:215959384
    海南冬青苷D; Ilexhainanoside D CFN90989 1137648-52-2 C36H56O11 = 664.83 10mg QQ客服:2056216494
    墨旱莲皂苷I; Eclalbasaponin I CFN91027 158511-59-2 C42H68O14 = 796.98 10mg QQ客服:2056216494
    竹节参皂苷IVa; Chikusetsusaponin IVa CFN92516 51415-02-2 C42H66O14 = 795.0 20mg QQ客服:215959384
    楤木皂苷A,竹节参皂苷IV; Chikusetsusaponin IV CFN90542 7518-22-1 C47H74O18 = 927.08 20mg QQ客服:215959384
    地肤子皂苷II; Momordin II CFN92562 95851-41-5 C47H74O18 = 927.1 5mg QQ客服:3257982914

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