• 中药标准品生产商,产品定制服务
  • 人参皂苷Rb2

    Ginsenoside Rb2

    人参皂苷Rb2
    产品编号 CFN99965
    CAS编号 11021-13-9
    分子式 = 分子量 C53H90O22 = 1079.27
    产品纯度 >=98%
    物理属性 White powder
    化合物类型 Triterpenoids
    植物来源 The roots of Panax ginseng C. A. Mey.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    人参皂苷Rb2 CFN99965 11021-13-9 10mg QQ客服:1413575084
    人参皂苷Rb2 CFN99965 11021-13-9 20mg QQ客服:1413575084
    人参皂苷Rb2 CFN99965 11021-13-9 50mg QQ客服:1413575084
    人参皂苷Rb2 CFN99965 11021-13-9 100mg QQ客服:1413575084
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Sri Ramachandra University (India)
  • Instituto de Investigaciones Agropecuarias (Chile)
  • University of Auckland (New Zealand)
  • Agricultural Research Organization (ARO) (Israel)
  • Griffith University (Australia)
  • Warszawski Uniwersytet Medyczny (Poland)
  • University of Eastern Finland (Finland)
  • Guangzhou Institutes of Biomedicine and Health (China)
  • University of Stirling (United Kingdom)
  • Semmelweis Unicersity (Hungary)
  • Hamdard University (India)
  • Sapienza University of Rome (Italy)
  • MTT Agrifood Research Finland (Finland)
  • Center for protein Engineering (CIP) (Belgium)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • China Pharmacy2015, 26(27)
  • Proc Natl Acad Sci USA.2016, 113(30):E4407-1
  • J Pharm Biomed Anal.2016, 129:50-59
  • Acta Chromatographica2016, 29(3)
  • Pharm Biol.2016, 54(7):1255-62
  • University of Central Lancashire2017, 20472
  • Phytochemistry Letters2017, 449-455
  • Sci Rep.2017, 7:40345
  • Sci Rep.2017, 7:467-479
  • Sci Rep. 2018, 10590
  • Evid Based Complement Alternat Med.2018, 2018:1073509
  • Sci Adv.2018, 4(10)
  • Sci Rep.2018, 8:9267
  • BMC Microbiol.2019, 19(1):78
  • Molecules.2019, 24(10):E1926
  • J of Dentistry & Oral Health2019, 2641-1962
  • Pak J Pharm Sci.2019, 32(6):2879-2885
  • Chin J Pharm Anal.2019, 39(7):1217-1228
  • J Asian Nat Prod Res.2019, 5:1-17
  • Phytomedicine.2019, 58:152893
  • Oxid Med Cell Longev2019, 9056845:13
  • Plos One.2020, 10.1371
  • Food Chem.2020, 313:126079
  • ...
  • 生物活性
    Description: Ginsenoside Rb2 shows hypoglycemic, anti-osteoporosis, anti-oxidant, anti-angiogenesis, and anti-tumor activities, it is a promising candidate as a mucosal immunoadjuvant to enhance antiviral activity and is a valuable component capable of lowering the levels of lipids. Ginsenoside Rb2 also possesses a protective role against the photoaging of human keratinocyte cells under UV-B irradiation, shows inhibitory effects on nicotinic stimulation-evoked catecholamine secretion, at least partly through the increased NO production due to the activation of nitric oxide synthase, which is relevant to neuronal nicotinic receptor blockade.
    Targets: NOS | Calcium Channel | Sodium Channel | ROS | IL Receptor | Antifection | SREBP | FAS | HVJ
    In vitro:
    Biosci Biotechnol Biochem. 2015 Mar 16:1-7.
    Suppressive properties of ginsenoside Rb2, a protopanaxadiol-type ginseng saponin, on reactive oxygen species and matrix metalloproteinase-2 in UV-B-irradiated human dermal keratinocytes.[Pubmed: 25774540]
    Ginsenosides, also known as ginseng saponins, are the principal bioactive ingredients of ginseng, which are responsible for its diverse pharmacological activities. The present work aimed to assess skin anti-photoaging properties of ginsenoside Rb2 (Rb2), one of the predominant protopanaxadiol-type ginsenosides, in human epidermal keratinocyte HaCaT cells under UV-B irradiation.
    METHODS AND RESULTS:
    When the cultured keratinocytes were subjected to Rb2 prior to UV-B irradiation, Rb2 displayed suppressive activities on UV-B-induced reactive oxygen species elevation and matrix metalloproteinase-2 expression and secretion. However, Rb2 at the used concentrations was unable to modulate cellular survivals in the UV-B-irradiated keratinocytes.
    CONCLUSIONS:
    In brief, Rb2 possesses a protective role against the photoaging of human keratinocyte cells under UV-B irradiation.
    Korean J Physiol Pharmacol. 2014 Oct;18(5):431-9.
    Inhibitory effects of ginsenoside-rb2 on nicotinic stimulation-evoked catecholamine secretion.[Pubmed: 25352764]
    The aim of the present study was to investigate whether ginsenoside Rb2 (Rb2) can affect the secretion of catecholamines (CA) in the perfused model of the rat adrenal medulla.
    METHODS AND RESULTS:
    Rb2 (3~30 μM), perfused into an adrenal vein for 90 min, inhibited ACh (5.32 mM)-evoked CA secretory response in a dose- and time-dependent fashion. Rb2 (10 μM) also time-dependently inhibited the CA secretion evoked by DMPP (100 μM, a selective neuronal nicotinic receptor agonist) and high K(+) (56 mM, a direct membrane depolarizer). Rb2 itself did not affect basal CA secretion (data not shown). Also, in the presence of Rb2 (50 μg/mL), the secretory responses of CA evoked by veratridine (a selective Na(+) channel activator (50 μM), Bay-K-8644 (an L-type dihydropyridine Ca(2+) channel activator, 10 μM), and cyclopiazonic acid (a cytoplasmic Ca(2+)-ATPase inhibitor, 10 μM) were significantly reduced, respectively. Interestingly, in the simultaneous presence of Rb2 (10 μM) and L-NAME (an inhibitor of NO synthase, 30 μM), the inhibitory responses of Rb2 on ACh-evoked CA secretory response was considerably recovered to the extent of the corresponding control secretion compared with the inhibitory effect of Rb2-treatment alone. Practically, the level of NO released from adrenal medulla after the treatment of Rb2 (10 μM) was greatly elevated compared to the corresponding basal released level.
    CONCLUSIONS:
    Collectively, these results demonstrate that Rb2 inhibits the CA secretory responses evoked by nicotinic stimulation as well as by direct membrane-depolarization from the isolated perfused rat adrenal medulla. It seems that this inhibitory effect of Rb2 is mediated by inhibiting both the influx of Ca(2+) and Na(+) into the adrenomedullary chromaffin cells and also by suppressing the release of Ca(2+) from the cytoplasmic calcium store, at least partly through the increased NO production due to the activation of nitric oxide synthase, which is relevant to neuronal nicotinic receptor blockade.
    In vivo:
    Biol Pharm Bull. 1994 May;17(5):635-9.
    Inhibition of tumor angiogenesis and metastasis by a saponin of Panax ginseng, ginsenoside-Rb2.[Pubmed: 7522731]
    We studied the effect of ginsenoside Rb2 extracted from Panax ginseng on angiogenesis and metastasis produced by B16-BL6 melanoma cells in syngeneic mice.
    METHODS AND RESULTS:
    Intravenous administration of ginsenoside Rb2 on day 1, 3 or 7 after tumor inoculation achieved a remarkable reduction in the number of vessels oriented toward the tumor mass, but did not cause a significant inhibition of tumor growth. The anti-angiogenic effect was dose-dependent ranging from 10 to 500 micrograms/mouse. In contrast, intra-tumoral or oral administration of ginsenoside Rb2 caused a marked inhibition of both neovascularization and tumor growth. Ginsenoside Rb2 did not affect the growth of rat lung endothelial (RLE) cells, B16-BL6 melanoma cells or various types of murine normal cells in vitro. The invasion of RLE cells into the reconstituted basement membrane (Matrigel), which is considered to be an essential event in tumor neovascularization, was inhibited by ginsenoside Rb2 in a concentration-dependent fashion, while ginsenoside Rb2 did not inhibit the haptotactic migration of endothelial cells to fibronectin-substrate. Multiple administrations of ginsenoside Rb2 after the intravenous inoculation of B16-BL6 melanoma cells resulted in a significant inhibition of lung metastasis as compared with the untreated control.
    CONCLUSIONS:
    These results suggest that the inhibition of tumor-associated angiogenesis by ginsenoside Rb2 may partly contribute to the inhibition of lung tumor metastasis.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 0.9266 mL 4.6328 mL 9.2655 mL 18.531 mL 23.1638 mL
    5 mM 0.1853 mL 0.9266 mL 1.8531 mL 3.7062 mL 4.6328 mL
    10 mM 0.0927 mL 0.4633 mL 0.9266 mL 1.8531 mL 2.3164 mL
    50 mM 0.0185 mL 0.0927 mL 0.1853 mL 0.3706 mL 0.4633 mL
    100 mM 0.0093 mL 0.0463 mL 0.0927 mL 0.1853 mL 0.2316 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    七叶胆苷 XLVI; Gypenoside XLVI CFN93372 94705-70-1 C48H82O19 = 963.2 10mg QQ客服:215959384
    人参皂苷F4; Ginsenoside F4 CFN90757 181225-33-2 C42H70O12 = 767.0 10mg QQ客服:2932563308
    人参皂苷MC; Ginsenoside MC CFN95232 175484-06-7 C41H70O12 = 755.0 10mg QQ客服:3257982914
    Gynosaponin I; Gynosaponin I CFN96182 1207861-69-5 C42H72O12 = 769.0 5mg QQ客服:2159513211
    人参皂苷F2; Ginsenoside F2 CFN99755 62025-49-4 C42H72O13 = 785.01 20mg QQ客服:215959384
    人参皂苷Rd2; Ginsenoside Rd2 (Quinquenoside L10) CFN95231 83480-64-2 C47H80O17 = 917.2 10mg QQ客服:215959384
    七叶胆苷XVI; Gypenoside XVII CFN90193 80321-69-3 C48H82O18 = 947.16 20mg QQ客服:2932563308
    人参皂苷Rb2; Ginsenoside Rb2 CFN99965 11021-13-9 C53H90O22 = 1079.27 20mg QQ客服:3257982914
    人参皂苷Rb3; Ginsenoside Rb3 CFN99966 68406-26-8 C53H90O22 = 1079.27 20mg QQ客服:215959384
    三七皂苷Fc; Notoginsenoside Fc CFN93283 88122-52-5 C58H98O26 = 1211.4 20mg QQ客服:1413575084

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产