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  • 人参皂苷Rb1

    Ginsenoside Rb1

    人参皂苷Rb1
    产品编号 CFN99964
    CAS编号 41753-43-9
    分子式 = 分子量 C54H92O23 = 1109.29
    产品纯度 >=98%
    物理属性 White powder
    化合物类型 Triterpenoids
    植物来源 The roots of Panax ginseng C. A. Mey.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    人参皂苷Rb1 CFN99964 41753-43-9 10mg QQ客服:2159513211
    人参皂苷Rb1 CFN99964 41753-43-9 20mg QQ客服:2159513211
    人参皂苷Rb1 CFN99964 41753-43-9 50mg QQ客服:2159513211
    人参皂苷Rb1 CFN99964 41753-43-9 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Illinois (USA)
  • Shanghai Institute of Organic Chemistry (China)
  • Julius Kühn-Institut (Germany)
  • Universita' Degli Studi Di Cagliari (Italy)
  • Utrecht University (Netherlands)
  • Martin Luther University of Halle-Wittenberg (Germany)
  • Universiti Kebangsaan Malaysia (Malaysia)
  • Florida A&M University (USA)
  • Korea Food Research Institute(KFRI) (Korea)
  • Vin?a Institute of Nuclear Sciences (Serbia)
  • Wageningen University (Netherlands)
  • Texas A&M University (USA)
  • Georgia Institute of Technology (USA)
  • Universiti Putra Malaysia(UPM) (Malaysia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • New Zealand J. Forestry Sci.2014, 44:17
  • Faculty of Chem. & Nat. Resource Eng.2014, 62
  • Sci Rep.2015, 5:13194
  • Food Chem.2016, 191:81-90
  • J Ethnopharmacol.2017, 198:87-90
  • Evid Based Complement Alternat Med.2017, 2017:6360836
  • Phytochemistry Letters2017, 449-455
  • Korean Journal of Pharmacognosy2017, 48(4):320-328
  • Front Immunol.2017, 8:1542
  • Appl Microbiol Biotechnol.2018, 102(12):5105-5120
  • Malaysian J of Fundamental and Applied Sciences 2018, 14(3):368-373
  • Evid Based Complement Alternat Med.2018, 2018:4259603
  • Evid Based Complement Alternat Med.2018, 2018:8565132
  • Asian Journal of Chemistry2018, 30(12):2699-2703
  • RSC Adv.2018, 32621-32636
  • Front Immunol.2018, 9:2091
  • Life Sci.2019, 216:259-270
  • Saudi Pharm J.2019, 27(1):145-153
  • Food Chem.2019, 276:768-775
  • Phytother Res.2019, 33(4):1104-1113
  • Int J Immunopathol Pharmacol.2019, 33:2058738419857537
  • Journal of Apiculture2019, 34(2):131-136
  • J Sep Sci.2020, 201901140
  • ...
  • 生物活性
    Description: Ginsenoside Rb1 is a protopanaxadiol that has diverse in vitro and in vivo effects, including neuroprotective, cardioprotective, anti-obesity, anti-inflammatory, and anti-oxidative actions. Ginsenoside Rb1 can up-regulate the expression of GLUTs in adipose tissue, in addition to activate insulin signalling pathway, and may effectively ameliorate the progression of asthma through Relegating Th1/Th2. It inhibited Na+, K+-ATPase activity with an IC50 of 6.3±1.0 μM, activated Akt, phosphorylating GSK-3β and inhibited mPTP opening.
    Targets: p38MAPK | JNK | GLUT | Akt | IFN-γ | IL Receptor | GSK-3 | HO-1 | PKA | Estrogen receptor | Progestogen receptor
    In vivo:
    Vascul Pharmacol. 2015 Oct;73:86-95.
    Ginsenoside Rb1 attenuates angiotensin II-induced abdominal aortic aneurysm through inactivation of the JNK and p38 signaling pathways.[Pubmed: 25912763]
    Abdominal aortic aneurysm (AAA), a life-threatening vascular disease, accounts for approximately 10% of the morbidity in people over 65years old. No satisfactory approach is available to treat AAA. Ginsenosides Rb1 and Rg1 are primary ingredients of Panax notoginseng for the treatment of cardiovascular diseases, but their impact on AAA is unknown.
    METHODS AND RESULTS:
    An AAA model was established using an Ang II infusion in ApoE-/- mice. After continuous stimulation of Ang II for 28days, suprarenal aortic aneurysms developed in 77% mice and 12% mice died suddenly due to AAA rupture. Administration of Ginsenoside Rb1 (20mg/kg/day), but not ginsenoside Rg1, significantly reduced the incidence and mortality of AAA. Ginsenoside Rb1 treatment dramatically suppressed Ang II-induced diameter enlargement, extracellular matrix degradation, matrix metalloproteinase (MMP) production, inflammatory cell infiltration, and vascular smooth muscle cell (VSMC) dysfunction. Mechanistic studies indicated that the protective effects of Ginsenoside Rb1 were associated with the inactivation of JNK and p38 MAPK signaling pathways. A specific activator of JNK and p38, anisomycin, nearly abolished Ginsenoside Rb1-driven suppression of MMP secretion by VSMCs.
    CONCLUSIONS:
    Ginsenoside Rb1, as a potential anti-AAA agent, suppressed AAA through inhibiting the JNK and p38 signaling pathways.
    Inflammation. 2015 Oct;38(5):1814-22.
    Anti-Asthmatic Effects of Ginsenoside Rb1 in a Mouse Model of Allergic Asthma Through Relegating Th1/Th2.[Pubmed: 25832478]
    The aim of the study was to investigate the anti-asthma effects of ginsenoside Rb1 (Rb1) and its possible mechanisms.
    METHODS AND RESULTS:
    A total of 50 mice were randomly assigned to five experimental groups: control, model, dexamethasone (2 mg/kg), and Rb1 (10 and 20 mg/kg). Airway resistance (RI) was measured; histological studies were evaluated by the hematoxylin and eosin (HE) staining; Th1/Th2, ovalbumin (OVA)-specific serum, and bronchoalveolar lavage fluid (BALF) IgE levels were evaluated enzyme-linked immunosorbent assay (ELISA); and T-bet/GATA3 proteins were evaluated by Western blot. Our study demonstrated that Rb1 inhibited OVA-induced increases in RI and eosinophil counts; interleukin (IL)-4 was recovered, and IFN-γlevel increased in bronchoalveolar lavage fluid. Histological studies demonstrated that Rb1 substantially inhibited OVA-induced eosinophilia in lung tissue. Western blot studies demonstrated that Rb1 substantially inhibited GATA3 and increased T-bet.
    CONCLUSIONS:
    These findings suggest that Rb1 may effectively ameliorate the progression of asthma and could be used as a therapy for patients with allergic asthma.
    Pharmacogn Mag. 2014 Oct;10(40):458-63.
    Effects of ginsenosides-Rb1 on exercise-induced oxidative stress in forced swimming mice.[Pubmed: 25422546]
    The fleshy root of Panax ginseng C.A. Meyer (ginseng) is one of the most well-known and valued herbs in traditional Chinese medicine. Ginsenosides are considered mainly responsible for the pharmacological activities of ginseng. The purpose of this study was to investigate the effects of ginsenoside-Rb1 (G-Rb1) on swimming exercise-induced oxidative stress in male mice.
    METHODS AND RESULTS:
    A total of 48 animals were randomly divided into four groups, with twelve mice in each group. The first, second and third groups were designed as G-Rb1 treatment groups, got 25, 50 and 100 mg/kg bodyweight of G-Rb1, respectively. The fourth group was designed as the control group, got physiologic saline. The mice were intragastrically administered once daily for 4 weeks. The weight-loaded forced swimming test was conducted on the final day of experimentation. Then the exhaustive swimming time, blood lactate, serum creatine kinase (CK), malondialdehyde (MDA) and antioxidant enzymes in liver of mice were measured. The results showed that G-Rb1 could prolong the exhaustive swimming time and improve exercise endurance capacity of mice, as well as accelerate the clearance of blood lactate and decrease serum CK activities. Meanwhile, G-Rb1 could decrease MDA contents and increase superoxide dismutase, catalase, glutathione peroxidase activities in liver of mice.
    CONCLUSIONS:
    The study suggested that G-Rb1 possessed protective effects on swimming exercise-induced oxidative stress in mice.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 0.9015 mL 4.5074 mL 9.0148 mL 18.0296 mL 22.5369 mL
    5 mM 0.1803 mL 0.9015 mL 1.803 mL 3.6059 mL 4.5074 mL
    10 mM 0.0901 mL 0.4507 mL 0.9015 mL 1.803 mL 2.2537 mL
    50 mM 0.018 mL 0.0901 mL 0.1803 mL 0.3606 mL 0.4507 mL
    100 mM 0.009 mL 0.0451 mL 0.0901 mL 0.1803 mL 0.2254 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    三七皂苷R4; Notoginsenoside R4 CFN91142 87741-77-3 C59H100O27 = 1241.4 5mg QQ客服:2159513211
    人参皂苷Ra2; Ginsenoside Ra2 CFN93293 83459-42-1 C58H98O26 = 1211.39 5mg QQ客服:3257982914
    三七皂苷Fe; Notoginsenoside Fe CFN93282 88105-29-7 C47H80O17 = 917.12 20mg QQ客服:1413575084
    人参皂苷Rc; Ginsenoside Rc CFN99973 11021-14-0 C53H90O22 = 1079.27 20mg QQ客服:215959384
    人参皂苷F1; Ginsenoside F1 CFN99754 53963-43-2 C36H62O9 = 638.88 20mg QQ客服:1413575084
    3-乙酰人参皂苷F1; 3-Acetyl-ginsenoside F1 CFN95238 N/A C38H64O10 = 680.9 5mg QQ客服:1413575084
    人参皂苷F3; Ginsenoside F3 CFN99978 62025-50-7 C41H70O13 = 770.99 10mg QQ客服:2159513211
    人参皂苷F5; Ginsenoside F5 CFN95034 189513-26-6 C41H70O13 = 771.0 20mg QQ客服:1148253675
    人参皂苷Rg1; Ginsenoside Rg1 CFN99967 22427-39-0 C42H72O14 = 801.01 20mg QQ客服:2159513211
    三七皂苷R1; Notoginsenoside R1 CFN99999 80418-24-2 C47H80O18 = 933.13 20mg QQ客服:2932563308

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