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  • 日耳曼醇

    Germanicol

    日耳曼醇
    产品编号 CFN89221
    CAS编号 465-02-1
    分子式 = 分子量 C30H50O = 426.72
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The barks of Lecythis pisonis.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    日耳曼醇 CFN89221 465-02-1 1mg QQ客服:2056216494
    日耳曼醇 CFN89221 465-02-1 5mg QQ客服:2056216494
    日耳曼醇 CFN89221 465-02-1 10mg QQ客服:2056216494
    日耳曼醇 CFN89221 465-02-1 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
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    IF=12.804(2019)

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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int J Mol Sci.2019, 20(3):E651
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  • The Journal of Supercritical Fluids2021, 176:105305.
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  • Biomed Chromatogr.2019, 8:e4774
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  • Asian Journal of Chemistry2014, 26(22):7811-7816
  • Molecules.2018, 23(11):E2837
  • Applied Biological Chemistry2020, 63:33(2020)
  • US20170000760 A12016, 42740
  • Foods.2022, 12(1):136.
  • J Agric Food Chem.2020, 68(51):15164-15175
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  • ...
  • 生物活性
    Description: Germanicol induces selective growth inhibitory effects in human colon HCT-116 and HT29 cancer cells through induction of apoptosis, cell cycle arrest and inhibition of cell migration. Germanicol may have anti-inflammatory effects .
    Targets: Immunology & Inflammation related
    In vitro:
    J BUON. 2016 May-Jun;21(3):626-32.
    Germanicol induces selective growth inhibitory effects in human colon HCT-116 and HT29 cancer cells through induction of apoptosis, cell cycle arrest and inhibition of cell migration.[Pubmed: 27569083]
    The main aim of this research was to evaluate the anticancer and apoptotic effects of germanicol - a natural triterpene - in HCT-116 and HT29 human colon cancer cells and deciphering its mode of action by studying its effect on the cell cycle and cell migration.
    METHODS AND RESULTS:
    Cell cytotoxicity was evaluated by MTT assay, while cell death was assessed by LDH assay. Fluorescence microscopy, using DAPI and acridine orange/ethidium bromide (AO-ETBR), was carried out to evaluate the effect of germanicol on cellular morphology and apoptosis induction. Apoptosis quantification was performed by Annexin V-FITC assay, while cell cycle analysis was performed by flow cytometry using propidium iodide (PI). The results revealed that Germanicol showed selective, potent and dose-dependent cytotoxicity in HCT-116 and HT29 human colon cancer cells, while it showed lower cytotoxicity in normal colon cells (human colon fibroblast, CCD-18Co). LDH assay also showed that Germanicol induced dose-dependent cell death in HCT-116 and HT29 cells. Fluorescence microscopy revealed that Germanicol induced apoptosis via chromatin condensation and DNA damage in HCT-116 colon cancer cells. It also revealed that the percentage of cells with orange and red fluorescence increased when adding a Germanicol dose, indicating apoptosis. Germanicol also inhibited cancer cell migration.
    CONCLUSIONS:
    The current findings reveal that Germanicol exhibits selective antiproliferative activity against two human colon cancer cells. The normal cell line was less affected by the drug, as compared to the two cancer cell lines, indicating that Germanicol will not target normal living cells. The antiproliferative effect was shown to be mediated through the induction of apoptosis and suppression of cell migration.
    In vivo:
    Phytother Res. 2010 Oct;24(10):1496-500.
    Antiinflammatory properties of Morus nigra leaves.[Pubmed: 20878700 ]

    METHODS AND RESULTS:
    The aim of the present study was to investigate antiinflammatory activity of the methylene chloride extract of Morus nigra in animal models. Carrageenan-induced paw edema as well as fibrovascular tissue growth induced by s.c. cotton pellet implantation were used to investigate the antiinflammatory activity of Morus nigra extract (MnE) in rats. A HPLC fingerprint was used for phytochemical analysis of the extracts.
    CONCLUSIONS:
    The MnE at test doses of 100-300 mg/kg p.o. clearly demonstrated antiinflammatory effects by reduced paw edema induced by carragenan and significantly inhibited the formation of granulomatous tissue. In addition, chemical compounds isolated from Morus nigra, including betulinic acid, β-sitosterol and Germanicol, may be responsible for the antiinflammatory effect of the extract.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.3435 mL 11.7173 mL 23.4346 mL 46.8691 mL 58.5864 mL
    5 mM 0.4687 mL 2.3435 mL 4.6869 mL 9.3738 mL 11.7173 mL
    10 mM 0.2343 mL 1.1717 mL 2.3435 mL 4.6869 mL 5.8586 mL
    50 mM 0.0469 mL 0.2343 mL 0.4687 mL 0.9374 mL 1.1717 mL
    100 mM 0.0234 mL 0.1172 mL 0.2343 mL 0.4687 mL 0.5859 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Germanicol acetate ; Germanicol acetate CFN96961 10483-91-7 C32H52O2 = 468.76 5mg QQ客服:2159513211
    beta-香树脂醇乙酸酯; beta-Amyrin acetate CFN99679 1616-93-9 C32H52O2 = 468.8 5mg QQ客服:2056216494
    beta-软脂酸香树精酯; beta-Amyrin palmitate CFN97009 5973-06-8 C46H80O2 = 665.1 5mg QQ客服:1413575084
    beta-白檀酮; beta-Amyrone CFN97099 638-97-1 C30H48O = 424.7 5mg QQ客服:2056216494
    9(11),12-齐墩果二烯-3beta-醇; 9(11),12-Oleanadien-3-ol CFN97528 94530-87-7 C30H48O = 424.7 5mg QQ客服:1413575084
    齐墩果-12-烯-3b,6b-二醇; 12-Oleanene-3,6-diol CFN94009 41498-79-7 C30H50O2 = 442.72 5 mg QQ客服:1413575084
    曼陀罗萜醇酮; Daturaolone CFN94010 41498-80-0 C30H48O2 = 440.71 5 mg QQ客服:1457312923
    黑果茜草萜 B ; Rubiprasin B CFN96835 125263-66-3 C32H52O4 = 500.76 5mg QQ客服:215959384
    黑果茜草萜 A ; Rubiprasin A CFN96836 125263-65-2 C32H52O5 = 516.76 5mg QQ客服:1413575084
    13(18)-齐墩果烯-3-醇,Α-香树素; 13(18)-Oleanen-3-ol CFN98801 508-04-3 C30H50O = 426.7 5mg QQ客服:1413575084

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