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  • 1,3,7-三羟基-9H-氧杂蒽-9-酮

    Gentisein

    1,3,7-三羟基-9H-氧杂蒽-9-酮
    产品编号 CFN92398
    CAS编号 529-49-7
    分子式 = 分子量 C13H8O5 = 244.2
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Xanthones
    植物来源 The herbs of Calophyllum inophyllum L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    1,3,7-三羟基-9H-氧杂蒽-9-酮 CFN92398 529-49-7 1mg QQ客服:1457312923
    1,3,7-三羟基-9H-氧杂蒽-9-酮 CFN92398 529-49-7 5mg QQ客服:1457312923
    1,3,7-三羟基-9H-氧杂蒽-9-酮 CFN92398 529-49-7 10mg QQ客服:1457312923
    1,3,7-三羟基-9H-氧杂蒽-9-酮 CFN92398 529-49-7 20mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Otago (New Zealand)
  • Texas A&M University (USA)
  • Universite Libre de Bruxelles (Belgium)
  • Universidad de Ciencias y Artes de Chiapas (Mexico)
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • Sri Ramachandra University (India)
  • Funda??o Universitária de Desenvolvimento (Brazil)
  • Michigan State University (USA)
  • Universidad de La Salle (Mexico)
  • Korea Institute of Oriental Medicine (Korea)
  • Instytut Nawozów Sztucznych w Pu?awach (Poland)
  • Universidade Federal de Goias (UFG) (Brazil)
  • Universidad de Buenos Aires (Argentina)
  • University of Stirling (United Kingdom)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Antioxidants (Basel).2020, 9(6):526.
  • Int Immunopharmacol.2023, 123:110572.
  • Int. Conference on Med. Sci. and Bio.2017, 17973
  • J Agric Food Chem.2016, 64(35):6783-90
  • Toxicol Appl Pharmacol.2021, 427:115668.
  • Food Control2022, 132:108434.
  • Phytomedicine.2022, 100:154058.
  • J. of The Korean Society of Food Culture2017, 144-149
  • Int Immunopharmacol.2021, 101(Pt A):108181.
  • Cytotechnology.2017, 69(5):765-773
  • Processes2021, 9(5),831.
  • Hum Exp Toxicol.2017, 36(11):1169-1176
  • Arch Pharm Res.2015, 38(6):1080-9
  • PLoS One.2022, 17(6):e0268505.
  • Mol Pharm.2018, 15(8):3285-3296
  • Mol Med Rep.2023 Oct;28(4):193.
  • GxABT2022, 2268.2:15515.
  • Chem Biol Interact.2019, 298:1-7
  • Enzyme Microb Technol.2022, 161:110111.
  • Life (Basel).2022, 12(12):2107.
  • J Liq Chromatogr R T2018, 41(12):761-769
  • Separations2021, 8(6),80.
  • Neuropharmacology2019, 151437
  • ...
  • 生物活性
    Description: Standard reference
    In vitro:
    Redox Rep. 2006;11(1):3-8.
    Effect of benzophenones from Hypericum annulatum on carbon tetrachloride-induced toxicity in freshly isolated rat hepatocytes.[Pubmed: 16571270]
    Five benzophenones and a xanthone, isolated from Hypericum annulatum Moris, were investigated for their protective effect against carbon tetrachloride toxicity in isolated rat hepatocytes.
    METHODS AND RESULTS:
    The benzophenones and the xanthone gentisein were administered alone (100 microM) and in combination with CCl4 (86 microM). CCl4 undergoes dehalogenation in the liver endoplasmic reticulum. This process leads to trichlormethyl radical (*CCl3) formation, initiation of lipid peroxidation, and measurable toxic effects on the hepatocytes. The levels of thiobarbituric acid reactive substances (TBARS) were assayed as an index of lipid peroxidation (LPO). Lactate dehydrogenase (LDH) leakage, cell viability and reduced glutathione (GSH) depletion were used as signs of cytotoxicity. CCl4 significantly decreased hepatocyte viability, GSH level and increased TBARS level and LDH leakage as compared to the control.
    CONCLUSIONS:
    Our data indicate that 2,3',5',6-tetrahydroxy-4-methoxybenzophenone, 2-O-alpha-L-arabinofuranosyl-3',5',6-trihydroxy-4-methoxybenzophenone and 2-O-alpha-L-3'-acetylarabinofuranosyl-3',5',6-trihydroxy-4-methoxybenzophenone showed weaker toxic effects compared to CCl4 and in combination showed statistically significant protection against the toxic agent.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.095 mL 20.475 mL 40.95 mL 81.9001 mL 102.3751 mL
    5 mM 0.819 mL 4.095 mL 8.19 mL 16.38 mL 20.475 mL
    10 mM 0.4095 mL 2.0475 mL 4.095 mL 8.19 mL 10.2375 mL
    50 mM 0.0819 mL 0.4095 mL 0.819 mL 1.638 mL 2.0475 mL
    100 mM 0.041 mL 0.2048 mL 0.4095 mL 0.819 mL 1.0238 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    1,5,6-Trihydroxy-3,7-dimethoxyxanthone ; 1,5,6-Trihydroxy-3,7-dimethoxyxanthone CFN89047 65008-02-8 C15H12O7 = 304.25 5mg QQ客服:1413575084
    1,5,6-三羟基双苯吡酮; 1,5,6-Trihydroxyxanthone CFN89364 5042-03-5 C13H8O5 = 244.19 5mg QQ客服:3257982914
    1,5,6-三羟基-3-甲氧基呫吨酮; 1,5,6-Trihydroxy-3-methoxyxanthone CFN89549 50868-52-5 C14H10O6 = 274.22 5mg QQ客服:1457312923
    1,3,6-Trihydroxy-2,5-dimethoxyxanthone; 1,3,6-Trihydroxy-2,5-dimethoxyxanthone CFN96911 345287-92-5 C15H12O7 = 304.25 5mg QQ客服:1457312923
    1,3,6-三羟基-2-甲氧基-8-甲基-9H-氧杂蒽-9-酮; Drimiopsin C CFN97257 773850-90-1 C15H12O6 = 288.3 5mg QQ客服:2056216494
    1,3,6-三羟基-4,5-二甲氧基-8-甲基-9H-氧杂蒽-9-酮; Drimiopsin D CFN97258 773850-91-2 C16H14O7 = 318.3 5mg QQ客服:2056216494
    3,6,8-三羟基-1-甲基呫吨酮; Norlichexanthone CFN98041 20716-98-7 C14H10O5 = 258.2 5mg QQ客服:2159513211
    Methyl 1,6-dihydroxy-3-methylxanthone-8-carboxylate; Methyl 1,6-dihydroxy-3-methylxanthone-8-carboxylate CFN89185 85003-85-6 C16H12O6 = 300.26 5mg QQ客服:1457312923
    枇杷呋喃; Eriobofuran CFN89145 97218-06-9 C14H12O4 = 244.24 5mg QQ客服:2056216494
    9-羟基枇杷呋喃; 9-Hydroxyeriobofuran CFN89153 167278-41-3 C14H12O5 = 260.24 5mg QQ客服:215959384

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