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  • 伽升沃E

    Garcinone E

    伽升沃E
    产品编号 CFN92697
    CAS编号 112649-21-5
    分子式 = 分子量 C28H32O6 = 464.6
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Xanthones
    植物来源 The fruits of Garcinia mangostana
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    伽升沃E CFN92697 112649-21-5 1mg QQ客服:2056216494
    伽升沃E CFN92697 112649-21-5 5mg QQ客服:2056216494
    伽升沃E CFN92697 112649-21-5 10mg QQ客服:2056216494
    伽升沃E CFN92697 112649-21-5 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • Leibniz-Institut für Pflanzenbiochemie (IPB) (Germany)
  • University of Limpopo (South Africa)
  • Stanford University (USA)
  • University of Hull (United Kingdom)
  • Universite Libre de Bruxelles (Belgium)
  • Charles University in Prague (Czech Republic)
  • Imperial College London (United Kingdom)
  • Instituto de Investigaciones Agropecuarias (Chile)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • VNU Journal of Science2023, 39(2):24-33.
  • Food Sci Biotechnol.2023, 32(7):997-1003.
  • Food Chem.2020, 327:126992.
  • Dicle Tip Dergisi2020, 47(2),423-430.
  • Heliyon.2023, e12778.
  • Bull. Pharm. Sci., Assiut University2020, 43(2):149-155.
  • Planta Med.2022, 88(9-10):794-804.
  • Agronomy 2021, 11(3),502.
  • Korean J. Medicinal Crop Sci.2022, 30(2):124-133
  • FASEB J.2019, 33(2):2026-2036
  • J Biomed Sci.2020, 27(1):60.
  • Toxicol Rep.2021, 8:1131-1142.
  • J Cell Physiol.2020, 10.1002
  • Int J Mol Sci.2021, 22(9):5012.
  • J Ethnopharmacol.2016, 192:370-381
  • The Korea Society of Pha.2014, 300-314
  • Int J Mol Sci.2020, 21(24):9369.
  • Neurochem Int.2018, 121:114-124
  • Int. J. of Food Properties2017, S108-S118
  • Food Chem.2019, 276:768-775
  • Int J Med Sci.2021, 18(10):2155-2161.
  • J Korean Society of Food Science & Nutrition2021, 50(9): 962-970
  • Biochem Biophys Res Commun.2018, 495(1):1271-1277
  • ...
  • 生物活性
    Description: Garcinone E is active constituents in the anticomplement assay used. Garcinone E exhibits potent activity in vitro against Plasmodium falciparum chloroquine-resistant strain W2, with IC50 values below 3 µM. It has potent cytotoxic effect on all hepatocellular carcinomas cell lines as well as on the other gastric and lung cancer cell lines included in the screen, may be potentially useful for the treatment of certain types of cancer.
    Targets: Antifection
    In vitro:
    Planta Med. 2002 Nov;68(11):975-9.
    Garcinone E, a xanthone derivative, has potent cytotoxic effect against hepatocellular carcinoma cell lines.[Pubmed: 12451486]
    Treatment of hepatocellular carcinomas (HCCs) with chemotherapy has generally been disappointing and it is most desirable to have more effective new drugs.
    METHODS AND RESULTS:
    We extracted and purified 6 xanthone compounds from the rinds (peel) of the fruits of Garcinia mangostana L., using partitioned chromatography and then tested the cytotoxic effects of these compounds on a panel of 14 different human cancer cell lines including 6 hepatoma cell lines, based on the MTT method. Several commonly used chemotherapeutic agents were included in the assay to determine the relative potency of the potential new drugs.
    CONCLUSIONS:
    Our results have shown that one of the xanthone derivatives which could be identified as Garcinone E has potent cytotoxic effect on all HCC cell lines as well as on the other gastric and lung cancer cell lines included in the screen. We suggest that Garcinone E may be potentially useful for the treatment of certain types of cancer.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1524 mL 10.7619 mL 21.5239 mL 43.0478 mL 53.8097 mL
    5 mM 0.4305 mL 2.1524 mL 4.3048 mL 8.6096 mL 10.7619 mL
    10 mM 0.2152 mL 1.0762 mL 2.1524 mL 4.3048 mL 5.381 mL
    50 mM 0.043 mL 0.2152 mL 0.4305 mL 0.861 mL 1.0762 mL
    100 mM 0.0215 mL 0.1076 mL 0.2152 mL 0.4305 mL 0.5381 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Parvifolixanthone A; Parvifolixanthone A CFN89058 906794-56-7 C28H32O6 = 464.55 5mg QQ客服:2056216494
    Latisxanthone C ; Latisxanthone C CFN89046 197447-32-8 C28H30O6 = 462.54 5mg QQ客服:3257982914
    Butyraxanthone B; Butyraxanthone B CFN92696 1141754-81-5 C28H30O6 = 462.5 5mg QQ客服:2056216494
    伽升沃E; Garcinone E CFN92697 112649-21-5 C28H32O6 = 464.6 5mg QQ客服:1413575084
    异藤黄氧蒽酮E; Isogarciniaxanthone E CFN97125 659747-28-1 C28H32O6 = 464.6 5mg QQ客服:1413575084
    藤黄呫吨酮E; Garciniaxanthone E CFN99816 173294-74-1 C28H32O6 = 464.6 5mg QQ客服:2159513211
    柄曲霉素; Sterigmatocystin CFN96575 10048-13-2 C18H12O6 = 324.29 5mg QQ客服:1457312923
    Griffipavixanthone; Griffipavixanthone CFN98089 219649-95-3 C36H28O12 = 652.6 5mg QQ客服:2159513211
    Bijaponicaxanthone C; Bijaponicaxanthone C CFN96574 872409-35-3 C36H30O13 = 670.62 5mg QQ客服:1457312923

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