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  • 没食子儿茶素没食子酸酯

    Gallocatechin gallate

    没食子儿茶素没食子酸酯
    产品编号 CFN96488
    CAS编号 5127-64-0
    分子式 = 分子量 C22H18O11 = 458.37
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The herbs of Celastrus orbiculatus
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    没食子儿茶素没食子酸酯 CFN96488 5127-64-0 1mg QQ客服:1413575084
    没食子儿茶素没食子酸酯 CFN96488 5127-64-0 5mg QQ客服:1413575084
    没食子儿茶素没食子酸酯 CFN96488 5127-64-0 10mg QQ客服:1413575084
    没食子儿茶素没食子酸酯 CFN96488 5127-64-0 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Sao Paulo (Brazil)
  • University of British Columbia (Canada)
  • Indian Institute of Science (India)
  • Biotech R&D Institute (USA)
  • University of Hawaii Cancer Center (USA)
  • University of Stirling (United Kingdom)
  • Istanbul University (Turkey)
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • University of Mysore (India)
  • Gyeongsang National University (Korea)
  • Universitas Airlangga (Indonesia)
  • University of Oslo (Norway)
  • Siksha O Anusandhan University (India)
  • University of Wollongong (Australia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Phytomedicine.2022, 100:154085.
  • Process Biochemistry2019, 85:106-115
  • Pharmacol Rep.2019, 71(2):289-298
  • Institute of Food Science & Technology2021, 56(11).
  • Oxid Med Cell Longev.2022, 2022:9139338.
  • Biomolecules.2020, 10(6):925.
  • Nat Prod Commun.2017, 12(5):771-778
  • Phytomedicine.2019, 62:152962
  • Nutrients.2022, 14(19):4170.
  • Food Funct.2020, 11(2):1322-1333.
  • Int J Mol Sci.2022, 23(20):12516.
  • LWT2020, 124:109163
  • Enzyme Microb Technol.2019, 122:64-73
  • Molecules.2019, 24(24):E4536
  • Viruses.2017, 9(10)
  • J of the Korean Society of Food Science and Nutrition2019, 32(2):148-154
  • Tropical J. of Pha. Research2017, 16(3):543-552
  • The Korea Journal of Herbology2016, 29-35
  • J Korean Soc Food Sci Nutr2020, doi: 10.3746.
  • Biochem Biophys Res Commun.2018, 505(1):194-200
  • J Traditional Thai Medical Res.2022, 8(1):pp1-14.
  • Natural Product Communications2021, 16(9):1-10.
  • Appl. Sci.2020, 10(20),7374.
  • ...
  • 生物活性
    Description: Gallocatechin gallate has strong antioxidative, and anti-obesity activities, it inhibits 3T3-L1 differentiation and lipopolysaccharide induced inflammation through MAPK and NF-κB signaling; it also may have anti-diabetic effects by increasing sensitivity of insulin. Gallocatechin gallate can decrease osteoclastogenesis at 20 microM, it has positive effects on bone metabolism through a double process of promoting osteoblastic activity and inhibiting osteoclast differentiations.
    Targets: NF-kB | PPAR | ROS | Fatty Acid Synthase | IL Receptor | MAPK
    In vitro:
    J Agric Food Chem. 2003 Dec 3;51(25):7303-7.
    Heat-epimerized tea catechins rich in gallocatechin gallate and catechin gallate are more effective to inhibit cholesterol absorption than tea catechins rich in epigallocatechin gallate and epicatechin gallate.[Pubmed: 14640575 ]
    It has been known that tea catechins, (-)-epicatechin (1), (-)-epigallocatechin (2), (-)-epicatechin gallate (3), and (-)-epigallocatechin gallate (4) are epimerized to(-)-catechin (5), (-)-gallocatechin (6), (-)-catechin gallate (7), and (-)-gallocatechin gallate (8), respectively, during retort pasteurization. We previously reported that tea catechins, mainly composed of 3 and 4, effectively inhibit cholesterol absorption in rats.
    METHODS AND RESULTS:
    In this study, the effect of heat-epimerized catechins on cholesterol absorption was compared with tea catechins. Both tea catechins and heat-epimerized catechins lowered lymphatic recovery of cholesterol in rats cannulated in the thoracic duct and epimerized catechins were more effective than tea catechins. The effect of purified catechins on micellar solubility of cholesterol was examined in an in vitro study. The addition of gallate esters of catechins reduced micellar solubility of cholesterol by precipitating cholesterol from bile salt micelles. Compounds 7 and 8 were more effective to precipitate cholesterol than 3 and 4, respectively.
    CONCLUSIONS:
    These observations strongly suggest that heat-epimerized catechins may be more hypocholesterolemic than tea catechins.
    Nippon Shokuhin Kagaku Kogaku Kaishi, 2000, 47(2):120-9.
    Relationship between antioxidative activity estimated by XYZ-dish method and catechin concentration in commercially available tea drinks.[Reference: WebLink]
    A relationship between antioxidative activity and catechin concentration was investigated for estimating antioxidative potency of commercially available tea drinks by using the XYZ-dish method.
    METHODS AND RESULTS:
    Antioxidative activity of canned drinks determined by the XYZ-dish method increased in the following order : other teasCONCLUSIONS:
    These results demonstrated that the XYZ-dish method was useful as an antioxidative assay of tea drinks containing polyphenolic antioxidant activity.
    In vivo:
    Medicinal Chemistry Research, 2013, 22(7):3372-8.
    Epimerization of epigallocatechin gallate to gallocatechin gallate and its anti-diabetic activity.[Reference: WebLink]
    Compared with epiGallocatechin gallate (EGCG), its epimer Gallocatechin gallate (GCG) is more stable and more bioactive, even when least contained in green tea.
    METHODS AND RESULTS:
    In this study, EGCG can be selectively epimerized into GCG catalyzed by a phosphate buffer (pH 5.8) at 60 °C for 2 h with the highest yield of 65.6 %. A plausible mechanism for this conversion was also presented. To evaluate the anti-diabetic activity of GCG, we had investigated an oral glucose tolerance test and determined the plasma levels of glucose, insulin, triglyceride, and free fatty acid in a streptozotocin-induced diabetic rat model system.
    CONCLUSIONS:
    The results suggested that both GCG and EGCG might have anti-diabetic effects by increasing sensitivity of insulin, and GCG is more active than EGCG.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1816 mL 10.9082 mL 21.8164 mL 43.6329 mL 54.5411 mL
    5 mM 0.4363 mL 2.1816 mL 4.3633 mL 8.7266 mL 10.9082 mL
    10 mM 0.2182 mL 1.0908 mL 2.1816 mL 4.3633 mL 5.4541 mL
    50 mM 0.0436 mL 0.2182 mL 0.4363 mL 0.8727 mL 1.0908 mL
    100 mM 0.0218 mL 0.1091 mL 0.2182 mL 0.4363 mL 0.5454 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    (+)-儿茶素 5-没食子酸酯; (+)-atechin 5-gallate CFN70264 128232-62-2 C22H18O10 = 442.4 5mg QQ客服:215959384
    (-)-没食子酸儿茶素酯;儿茶素没食子酸酯; (-)-Catechin gallate(CG) CFN98504 130405-40-2 C22H18O10 = 442.37 20mg QQ客服:2159513211
    (-)-棓儿茶酸; 没食子儿茶素; (-)-Gallocatechin CFN99137 3371-27-5 C15H14O7 = 306.27 20mg QQ客服:2159513211
    没食子儿茶素没食子酸酯; (-)-Gallocatechin gallate CFN99571 4233-96-9 C22H18O11 = 458.37 20mg QQ客服:1413575084
    没食子儿茶素没食子酸酯; Gallocatechin gallate CFN96488 5127-64-0 C22H18O11 = 458.37 5mg QQ客服:1413575084

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