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    Galanthaminone

    那维定
    产品编号 CFN90742
    CAS编号 510-77-0
    分子式 = 分子量 C17H19NO3 = 285.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The bulbs of Lycoris radiata
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    那维定 CFN90742 510-77-0 1mg QQ客服:2056216494
    那维定 CFN90742 510-77-0 5mg QQ客服:2056216494
    那维定 CFN90742 510-77-0 10mg QQ客服:2056216494
    那维定 CFN90742 510-77-0 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Florida International University (USA)
  • University of Stirling (United Kingdom)
  • Lodz University of Technology (Poland)
  • Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)
  • Universidade de Franca (Brazil)
  • Deutsches Krebsforschungszentrum (Germany)
  • University of Vigo (Spain)
  • Uniwersytet Medyczny w ?odzi (Poland)
  • Ateneo de Manila University (Philippines)
  • Uniwersytet Gdański (Poland)
  • Universiti Malaysia Pahang (Malaysia)
  • CSIRO - Agriculture Flagship (Australia)
  • Funda??o Universitária de Desenvolvimento (Brazil)
  • University of Toulouse (France)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Immunol.2023, ji2200727.
  • Trop J Nat Prod Res.2019, 3(1):6-9
  • J Applied Biological Chemistry2021, 64(2):185-192
  • J Food Biochem.2021, 45(7):e13774.
  • Pharmacognosy Journal.2020, 12(2), p232-235.
  • Phytomedicine.2022, 102:154183.
  • Int J Mol Sci.2021, 22(21):11447.
  • Biochem Biophys Res Commun.2021, 534:802-807.
  • J of App. Res. on Med&Aromatic Plants2020, 100291.
  • J Sci Food Agric.2023, 103(1):213-220.
  • Int J Mol Sci.2017, 19(1)
  • Emirates Journal of Food and Agriculture.2022, 34(6): 528-536.
  • Molecules.2021, 26(2):313.
  • Bull. Pharm. Sci., Assiut University2020, 43(2):149-155.
  • Molecules.2019, 24(1):E159
  • J Pharm Pharmacol.2022, rgac033.
  • Biology (Basel).2020, 9(11):363.
  • Phytomedicine.2019, 58:152893
  • Nutrients2020, 12(3):811.
  • Molecules 2022, 27(3),960.
  • Front Microbiol.2019, 10:2806
  • Sci Rep. 2017, 8207(7)
  • J Ethnopharmacol.2020, 269:113752.
  • ...
  • 生物活性
    Description: Galanthaminone (Narwedin) is a competitive and reversible cholinesterase (AChE) inhibitor; is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments.
    Targets: AChR | IL Receptor
    In vitro:
    European Journal of Drug Metabolism and Pharmacokinetics,1987,12(1):25-30.
    In vitro metabolism of galanthamine hydrobromide (Nivalin®) by rat and rabbit liver homogenate[Reference: WebLink]
    The metabolism of galanthamine hydrobromide (Nivalin®) was investigated in rat and rabbit liver homogenates.
    METHODS AND RESULTS:
    Experiments were carried out varying several parameters of incubation: substrate (galanthamine hydrobromide, galanthamine, Galanthaminone and epigalanthamine), cofactor enrichment (NADPH, NADP/G-6-P, NAD), pH (7.4 and 9.3), time of incubation. Substrates and metabolites were identified and quantitatively determined by GC/MS. In vitro metabolism in rat liver homogenate was negligible. The experiments with rabbit liver homogenate indicated, that galanthamine was actively metabolised the major metabolites being the oxidised product — Galanthaminone, and the isomer of galanthamine — epigalantamine.
    CONCLUSIONS:
    The experimental results show that the metabolism of galanthamine is substrate and product stereoselective.
    In vivo:
    Clin Pharmacol Ther. 1991 Oct;50(4):420-8.
    Pharmacokinetics of galanthamine in humans and corresponding cholinesterase inhibition.[Pubmed: 1914378]

    METHODS AND RESULTS:
    Measurements were done to determine the plasma concentrations of galanthamine and two of its metabolites, as well as the corresponding inhibition of acetylcholinesterase activity in erythrocytes after applying 5 and 10 mg galanthamine hydrobromide as a constant-rate intravenous infusion for 30 minutes and single oral doses of 10 mg in eight healthy male volunteers. The data obtained revealed first-order pharmacokinetics, complete oral bioavailability, and a mean terminal half-life of 5.68 hours (95% confidence interval, 5.17 to 6.25 hours). Renal clearance accounted for only 25% of the total plasma clearance (CL = 0.34 L.kg-1.hr-1). Only negligible quantities of the putative metabolites, epigalanthamine and Galanthaminone, were detected in blood and urine. The inhibition of acetylcholinesterase activity was closely correlated with the pharmacokinetics of galanthamine, a median maximal value of 53% being achieved by applying 10 mg galanthamine intravenously.
    CONCLUSIONS:
    Analysis of in vitro and ex vivo concentration responses revealed no differences, indicating that no metabolites of galanthamine exert additional inhibition of acetylcholinesterase activity.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.5051 mL 17.5254 mL 35.0508 mL 70.1016 mL 87.6271 mL
    5 mM 0.701 mL 3.5051 mL 7.0102 mL 14.0203 mL 17.5254 mL
    10 mM 0.3505 mL 1.7525 mL 3.5051 mL 7.0102 mL 8.7627 mL
    50 mM 0.0701 mL 0.3505 mL 0.701 mL 1.402 mL 1.7525 mL
    100 mM 0.0351 mL 0.1753 mL 0.3505 mL 0.701 mL 0.8763 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    伪石蒜碱; Pseudolycorine CFN98548 29429-03-6 C16H19NO4 = 289.33 5mg QQ客服:215959384
    盐酸石蒜碱; Lycorine chloride CFN99730 2188-68-3 C16H17NO4Cl = 323.78 20mg QQ客服:2056216494
    氧化石蒜碱; Ungeremine CFN93030 72510-04-4 C16H12NO3+ = 266.27 20mg QQ客服:2159513211
    二氢加兰他敏; Lycoramine CFN90745 21133-52-8 C17H23NO3 = 289.4 5mg QQ客服:2159513211
    O-去甲基加兰他敏; O-Desmethyl galanthamine CFN91708 60755-80-8 C16H19NO3 = 273.3 5mg QQ客服:2159513211
    加兰他敏; Galantamine CFN90743 357-70-0 C17H21NO3 = 287.4 5mg QQ客服:2056216494
    氢溴酸加兰他敏; Galantamine hydrobromide CFN90744 1953-04-4 C17H22BrNO3 = 368.3 20mg QQ客服:2056216494
    加兰他敏N-氧化物; Galanthamine 10-Oxide(Galanthamine N-Oxide) CFN91709 134332-50-6 C17H21NO4 = 303.4 5mg QQ客服:2159513211
    乙酰加兰他敏; O-Acetylgalanthamine CFN91707 25650-83-3 C19H23NO4 = 329.4 5mg QQ客服:3257982914
    那维定; Galanthaminone CFN90742 510-77-0 C17H19NO3 = 285.3 10mg QQ客服:1457312923

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