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  • 漆黄素

    Fisetin

    漆黄素
    产品编号 CFN98176
    CAS编号 528-48-3
    分子式 = 分子量 C15H10O6 = 286.24
    产品纯度 >=98%
    物理属性 Yellow cryst.
    化合物类型 Flavonoids
    植物来源 The herbs of Rhus succedanea L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    漆黄素 CFN98176 528-48-3 10mg QQ客服:2932563308
    漆黄素 CFN98176 528-48-3 20mg QQ客服:2932563308
    漆黄素 CFN98176 528-48-3 50mg QQ客服:2932563308
    漆黄素 CFN98176 528-48-3 100mg QQ客服:2932563308
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Dicle (Turkey)
  • Heinrich-Heine-University Düsseldorf (Germany)
  • National Chung Hsing University (Taiwan)
  • Chungnam National University (Korea)
  • Agricultural Research Organization (ARO) (Israel)
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • Rio de Janeiro State University (Brazil)
  • University of Melbourne (Australia)
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
  • Mahidol University (Thailand)
  • University of Vigo (Spain)
  • University of Brasilia (Brazil)
  • Universidad de La Salle (Mexico)
  • Heidelberg University (Germany)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • China Pharmacy2015, 26(27)
  • Acta Physiologiae Plantarum2015, 37:1736
  • Br J Pharmacol.2016, 173(2):396-410
  • The Korea Journal of Herbology2016, 29-35
  • J Ethnopharmacol.2017, 206:327-336
  • Invest New Drugs.2017, 35(2):166-179
  • J Chromatogr B Analyt Technol Biomed Life Sci.2018, 1080:27-36
  • Chem Biol Interact.2018, 283:59-74
  • Biol Pharm Bull.2018, 41(11):1685-1693
  • J Sep Sci.2018, 41(11):2488-2497
  • Sci Rep. 2018, 462(8)
  • Journal of Life Science2018, 917-922
  • Saf Health Work.2019, 10(2):196-204
  • Front Pharmacol.2019, 10:1355
  • Nutrients.2019, 11(11):E2694
  • Analytical methods2019, 11(6)
  • Int J Biol Macromol.2019, 126:653-661
  • Int J Mol Sci.2019, 21(1):E265
  • Molecules.2019, 24(22):E4022
  • Molecules.2019, 24(9):E1719
  • J Ethnopharmacol.2019, 241:112025
  • Comput Biol Chem.2019, 83:107096
  • J Pharmaceut Biomed2020, 178:112894
  • ...
  • 生物活性
    Description: Fisetin is an antimetastatic,antifungal, anti-inflammatory, antioxidant flavonoid, it has beneficial effect on periodontal disease, may via inhibiting MAPK activation and COX-2 expression without affecting cell viability. Fisetin can ameliorate photodamage by suppressing the mitogen-activated protein Kinase/Matrix metalloproteinase pathway and nuclear factor-κB pathways. Fisetin suppresses the accumulation of intracellular lipids by inhibiting GLUT4-mediated glucose uptake through inhibition of the mTOR-C/EBPα signaling in 3T3-L1 cells.
    Targets: COX | Caspase | GLUT | mTOR | PI3K | Akt | AMPK | NF-kB | PKC | ERK | p38MAPK | MMP(e.g.TIMP) | PGE | ERK | JNK | NO | ROS | Antifection
    In vitro:
    Arch Biochem Biophys. 2014 Dec 1;563:108-17.
    Involvement of ER stress and activation of apoptotic pathways in fisetin induced cytotoxicity in human melanoma.[Pubmed: 25016296]
    Fisetin, a dietary flavonoid is currently being investigated for its growth inhibitory properties in various cancer models. We previously showed that Fisetin inhibited melanoma growth in vitro and in vivo.
    METHODS AND RESULTS:
    Here, we evaluated the molecular basis of Fisetin induced cytotoxicity in metastatic human melanoma cells. Fisetin treatment induced endoplasmic reticulum (ER) stress in highly aggressive A375 and 451Lu human melanoma cells, as revealed by up-regulation of ER stress markers including IRE1α, XBP1s, ATF4 and GRP78. Time course analysis indicated that the ER stress was associated with activation of the extrinsic and intrinsic apoptotic pathways. Fisetin treated 2-D melanoma cultures displayed autophagic response concomitant with induction of apoptosis. Prolonged treatment (16days) with Fisetin in a 3-D reconstituted melanoma model resulted in inhibition of melanoma progression with significant apoptosis, as evidenced by increased staining of cleaved Caspase-3 in the treated constructs. However, no difference in the expression of autophagic marker LC-3 was noted between treated and control groups. Fisetin treatment to 2-D melanoma cultures resulted in phosphorylation and activation of the multifunctional AMP-activated protein kinase (AMPK) involved in the regulation of diverse cellular processes, including autophagy and apoptosis. Silencing of AMPK failed to prevent cell death indicating that Fisetin induced cytotoxicity is mediated through both AMPK-dependent and -independent mechanisms.
    CONCLUSIONS:
    Taken together, our studies confirm apoptosis as the primary mechanism through which Fisetin inhibits melanoma cell growth and that activation of both extrinsic and intrinsic pathways contributes to Fisetin induced cytotoxicity.
    J Med Chem. 2012 Jan 12;55(1):378-89.
    Chemical modification of the multitarget neuroprotective compound fisetin.[Pubmed: 22192055 ]
    Many factors are implicated in age-related central nervous system (CNS) disorders, making it unlikely that modulating only a single factor will provide effective treatment. Perhaps a better approach is to identify small molecules that have multiple biological activities relevant to the maintenance of brain function.
    METHODS AND RESULTS:
    Recently, we identified an orally active, neuroprotective, and cognition-enhancing molecule, the flavonoid fisetin, that is effective in several animal models of CNS disorders. Fisetin has direct antioxidant activity and can also increase the intracellular levels of glutathione (GSH), the major endogenous antioxidant. In addition, fisetin has both neurotrophic and anti-inflammatory activity. However, its relatively high EC(50) in cell based assays, low lipophilicity, high topological polar surface area (tPSA), and poor bioavailability suggest that there is room for medicinal chemical improvement.
    CONCLUSIONS:
    Here we describe a multitiered approach to screening that has allowed us to identify fisetin derivatives with significantly enhanced activity in an in vitro neuroprotection model while at the same time maintaining other key activities.
    BMC Complement Altern Med. 2014 Jul 16;14:245.
    Antifungal and cytotoxicity activities of the fresh xylem sap of Hymenaea courbaril L. and its major constituent fisetin.[Pubmed: 25027026 ]
    The great potential of plants as Hymenaea courbaril L (jatoba) has not yet been throughly explored scientifically and therefore it is very important to investigate their pharmacological and toxicological activities to establish their real efficacy and safety. This study investigated the cytotoxicity of xylem sap of Hymenaea courbaril L and its bioactivity against the fungi Cryptococcus neoformans species complex and dermatophytes.
    METHODS AND RESULTS:
    The fresh xylem sap of H. courbaril was filtered resulting in an insoluble brown color precipitate and was identified as fisetin. In the filtrate was identified the mixture of fisetinediol, fustin, 3-O-methyl-2,3-trans-fustin and taxifolin, which were evaluated by broth microdilution antifungal susceptibility testing against C. neoformans species complex and dermatophytes. The fresh xylem sap and fisetin were screened for cytotoxicity against the 3T3-A31 cells of Balb/c using neutral red uptake (NRU) assay. The fresh xylem sap and the fisetin showed higher in vitro activity than the filtrate. The xylem sap of H. courbaril inhibited the growth of dermatophytes and of C. neoformans with minimal inhibition concentration (MIC) < 256 μg/mL, while the fisetin showed MIC < 128 μg/mL for these fungi. Fisetin showed lower toxicity (IC50 = 158 μg/mL) than the fresh xylem sap (IC50 = 109 μg/mL).
    CONCLUSIONS:
    Naturally occurring fisetin can provide excellent starting points for clinical application and can certainly represent a therapeutic potential against fungal infections, because it showed in vitro antifungal activity and low toxicity on animal cells.
    In vivo:
    Eur J Pharmacol. 2015 Jun 20;764:79-86.
    Fisetin regulates TPA-induced breast cell invasion by suppressing matrix metalloproteinase-9 activation via the PKC/ROS/MAPK pathways.[Pubmed: 26101063]
    Invasion and metastasis are among the main causes of death in patients with malignant tumors. Fisetin (3,3',4',7-tetrahydroxyflavone), a natural flavonoid found in the smoke tree (Cotinus coggygria), is known to have antimetastatic effects on prostate and lung cancers; however, the effect of fisetin on breast cancer metastasis is unknown.
    METHODS AND RESULTS:
    The aim of this study was to determine the anti-invasive activity of fisetin in human breast cancer cells. Matrix metalloproteinase (MMP)-9 is a major component facilitating the invasion of many cancer tumor cell types, and thus the inhibitory effect of fisetin on MMP-9 expression in 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated human breast cancer cells was investigated in this study. Fisetin significantly attenuated TPA-induced cell invasion in MCF-7 human breast cancer cells, and was found to inhibit the activation of the PKCα/ROS/ERK1/2 and p38 MAPK signaling pathways. This effect was furthermore associated with reduced NF-κB activation, suggesting that the anti-invasive effect of fisetin on MCF-7 cells may result from inhibited TPA activation of NF-κB and reduced TPA activation of PKCα/ROS/ERK1/2 and p38 MAPK signals, ultimately leading to the downregulation of MMP-9 expression.
    CONCLUSIONS:
    Our findings indicate the role of fisetin in MCF-7 cell invasion, and clarify the underlying molecular mechanisms of this role, suggesting fisetin as a potential chemopreventive agent for breast cancer metastasis.
    J Agric Food Chem. 2015 May 13;63(18):4551-60.
    Fisetin Ameliorated Photodamage by Suppressing the Mitogen-Activated Protein Kinase/Matrix Metalloproteinase Pathway and Nuclear Factor-κB Pathways.[Pubmed: 25882230]
    Ultraviolet (UV) irradiation is one of the most important extrinsic factors contributing to skin photodamage. After UV irradiation, a series of signal transductions in the skin will be activated, leading to inflammatory response and photoaged skin. In this study, Fisetin, a flavonol that exists in fruits and vegetables, was investigated for its photoprotective effects.
    METHODS AND RESULTS:
    The results revealed that 5-25 μM Fisetin inhibits cyclooxygenase-2 (COX-2) and matrix metalloproteinase (MMP)-1, MMP-3, MMP-9 expression induced by ultraviolet B (UVB) irradiation in human skin fibroblasts. In addition, Fisetin suppressed UVB-induced collagen degradation. With regard to its effect on upper-stream signal transduction, we found that Fisetin reduced the expression of ultraviolet (UV)-induced ERK, JNK, and p38 phosphorylation in the mitogen-activated protein kinase (MAP kinase) pathway. Furthermore, Fisetin reduced inhibitor κB (IκB) degradation and increased the amount of p65, which is a major subunit of nuclear factor-κB (NF-κB), in cytoplasm. It also suppressed NF-κB translocated to the nucleus and inhibited cAMP response element-binding protein (CREB) Ser-133 phosphorylation level in the phosphoinositide 3-kinase/protein kinase B/CREB (PI3K/AKT/CREB) pathway.
    CONCLUSIONS:
    Finally, Fisetin inhibited UV-induced intracellular reactive oxygen species (ROS), prostaglandin E2 (PGE2), and nitric oxide (NO) generation. The mentioned effects and mechanisms suggest that Fisetin can be used in the development of photoprotective agents.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.4936 mL 17.4679 mL 34.9357 mL 69.8714 mL 87.3393 mL
    5 mM 0.6987 mL 3.4936 mL 6.9871 mL 13.9743 mL 17.4679 mL
    10 mM 0.3494 mL 1.7468 mL 3.4936 mL 6.9871 mL 8.7339 mL
    50 mM 0.0699 mL 0.3494 mL 0.6987 mL 1.3974 mL 1.7468 mL
    100 mM 0.0349 mL 0.1747 mL 0.3494 mL 0.6987 mL 0.8734 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    乙酰艾黄素; 乙酸六棱菊亭酯; Artemetin acetate CFN97530 95135-98-1 C22H22O9 = 430.4 5mg QQ客服:1148253675
    槲皮素; Quercetin CFN99272 117-39-5 C15H10O7 = 302.2 20mg QQ客服:215959384
    杜鹃黄素; Azaleatin CFN91007 529-51-1 C16H12O7 = 316.3 10mg QQ客服:2159513211
    3-O-甲基槲皮素; 3-O-Methylquercetin CFN99616 1486-70-0 C16H12O7 = 316.3 5mg QQ客服:2932563308
    四乙酸3-O-甲基槲皮素酯; 3-O-Methylquercetin tetraacetate CFN99615 1486-69-7 C24H20O11 = 484.4 5mg QQ客服:2159513211
    beta-鼠李素; beta-Rhamnocitrin CFN92328 90-19-7 C16H12O7 = 316.3 5mg QQ客服:2932563308
    3,7-二-O-甲基槲皮素; 3,7-Di-O-methylquercetin CFN96221 2068-02-2 C17H14O7 = 330.3 5mg QQ客服:1413575084
    5,7-二甲氧基-3,3',4'-三羟基黄酮; 5,7-Di-O-methylquercetin CFN92429 13459-07-9 C17H14O7 = 330.3 5mg QQ客服:3257982914
    棉花素; Gossypetin CFN91897 489-35-0 C15H10O8 = 318.24 5mg QQ客服:215959384
    棉花皮素 3-甲醚; Gossypetin 3-methylether CFN70462 86749-51-1 C16H12O8 = 332.3 5mg QQ客服:215959384

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