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  • 桉脂素

    Eudesmin

    桉脂素
    产品编号 CFN96266
    CAS编号 526-06-7
    分子式 = 分子量 C22H26O6 = 386.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Lignans
    植物来源 The dry leaves of Haplophyllum perforatum Kar.et Kir.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    桉脂素 CFN96266 526-06-7 10mg QQ客服:2159513211
    桉脂素 CFN96266 526-06-7 20mg QQ客服:2159513211
    桉脂素 CFN96266 526-06-7 50mg QQ客服:2159513211
    桉脂素 CFN96266 526-06-7 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Vigo (Spain)
  • University of Limpopo (South Africa)
  • University of Medicine and Pharmacy (Romania)
  • Worcester Polytechnic Institute (USA)
  • Center for protein Engineering (CIP) (Belgium)
  • University of Illinois at Chicago (USA)
  • Wageningen University (Netherlands)
  • Universiti Kebangsaan Malaysia (Malaysia)
  • Medical University of South Carolina (USA)
  • Florida International University (USA)
  • Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)
  • Istanbul University (Turkey)
  • University Medical Center Mainz (Germany)
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules.2017, 22(3)
  • J Sep Sci.2020, 201901140
  • Phytochem Anal.2021, 32(6):970-981.
  • Antioxidants.2022, 11(3):491.
  • Front Immunol.2020, 11:598556.
  • Kaohsiung J Med Sci.2023, 10.1002/kjm2.12764
  • Antioxidants (Basel).2021, 10(11): 1802.
  • Biomed Chromatogr.2020, e5021.
  • Microbiol. Biotechnol. Lett.2022, 50(2): 193-201.
  • Asian Pac J Cancer Prev.2021, 22(S1):97-106.
  • Acta Physiologiae Plantarum2016, 38:7
  • QASCF2022, 14(4).
  • Plant Biotechnology Reports 2021, 15:117-124.
  • Food Chem.2020, 332:127412
  • Food and Fermentation Industries2019, 45(7):45-51
  • Plants (Basel).2021, 10(5):951.
  • J Bone Miner Res.2017, 32(12):2415-2430
  • J. of Med. Plant Research.2013, 90-151
  • Planta Med.2018, 84(6-07):465-474
  • J Korean Med Ophthalmol Otolaryngol Dermatol2023, 36(1):21-39.
  • Hindawi J of Food Biochemistry2023, P17:8883860
  • Industrial Food Engineering2015, 19(4):408-413
  • Nutrients.2020, 12(12):3638.
  • ...
  • 生物活性
    Description: Eudesmin shows antiinflammatory, neuritogenic, anticonvulsant and sedative effects, the mechanism of eudesmin may be related to up-regulation of GABAA and GAD65 expressions, and anti-apoptosis of neuron the in brain.50 microM (+)-eudesmin can induce neurite outgrowth and enhance nerve growth factor (NGF)-mediated neurite outgrowth from PC12 cells by stimulating up-stream MAPK, PKC and PKA pathways.
    Targets: TNF-α | MAPK | PKC | PKA | GABA Receptor | NGF
    In vitro:
    Arch Pharm Res. 1999 Aug;22(4):348-53.
    Eudesmin inhibits tumor necrosis factor-alpha production and T cell proliferation.[Pubmed: 10489872]
    Possible antiinflammatory effects of eudesmin were examined by assessing the effects on tumor necrosis factor (TNF)-alpha production and lymphocyte proliferation as well as cytotoxicity against murine and human macrophages.
    METHODS AND RESULTS:
    The compound significantly inhibited TNF-alpha production by lipopolysaccharide (LPS)-stimulated murine macrophage RAW264.7 without displaying cytotoxicity suggesting that eudesmin may inhibit TNF-alpha production without any interference of normal cell function. It also significantly attenuated T cell proliferation stimulated by concanavalin A (Con A) in a dose-dependent manner.
    Arch Pharm Res. 2006 Dec;29(12):1114-8.
    Effects of (+)-eudesmin from the stem bark of magnolia kobus DC. var. borealis Sarg. on neurite outgrowth in PC12 cells.[Pubmed: 17225460]

    METHODS AND RESULTS:
    (+)-Eudesmin [4,8-bis(3,4-dimethoxyphenyl)-3,7-dioxabicyclo[3.3.0]octane] was isolated from the stem bark of Magnolia kobus DC. var. borealis Sarg. and found to have neuritogenic activity. 50 microM (+)-eudesmin induced neurite outgrowth and enhanced nerve growth factor (NGF)-mediated neurite outgrowth from PC12 cells. At this concentration, (+)-eudesmin also enhanced NGF-induced neurite-bearing activity and this activity was partially blocked by various protein kinase inhibitors. These included PD98059, a mitogen-activated protein kinase (MAPK) kinase inhibitor. GF109203X, a protein kinase C (PKC) inhibitor and H89, a protein kinase A (PKA) inhibitor.
    CONCLUSIONS:
    These results suggest that (+)-eudesmin can induce neurite outgrowth from PC12 cells by stimulating up-stream MAPK, PKC and PKA pathways.
    In vivo:
    Phytother Res. 2015 Jul;29(7):996-1003
    Anticonvulsant and Sedative Effects of Eudesmin isolated from Acorus tatarinowii on mice and rats.[Pubmed: 25851178 ]
    This paper was designed to investigate anticonvulsant and sedative effects of eudesmin isolated from Acorus tatarinowii.
    METHODS AND RESULTS:
    The eudesmin (5, 10, and 20 mg/kg) was administered intraperitoneally (i.p.). The maximal electroshock test (MES) and pentylenetertrazole (PTZ)-induced seizures in male mice were used to evaluate anticonvulsant activities of eudesmin, and sedative effects of eudesmin were evaluated by pentobarbital sodium-induced sleeping time (PST) and locomotor activity in mice. Finally, the mechanisms of eudesmin were investigated by determining contents of glutamic acid (Glu) and gamma-aminobutyric acid (GABA) in epileptic mice, and expressions of glutamate decarboxylase 65 (GAD65), GABAA , Bcl-2, and caspase-3 in the brain of chronic epileptic rats. Results of MES and PTZ tests revealed that eudesmin possesses significant anticonvulsant effects, and the PST and locomotor activity tests demonstrated that eudesmin has significant sedative effects. Furthermore, our study revealed that after treatment with eudesmin, GABA contents increased, whereas Glu contents decreased, and ratio of Glu/GABA decreased. Our results also indicated that expressions of GAD65, GABAA, and Bcl-2 were up-regulated by treating with eudesmin, whereas the caspase-3 obviously was down-regulated.
    CONCLUSIONS:
    In conclusion, eudesmin has significant anticonvulsant and sedative effects, and the mechanism of eudesmin may be related to up-regulation of GABAA and GAD65 expressions, and anti-apoptosis of neuron the in brain.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.588 mL 12.94 mL 25.8799 mL 51.7598 mL 64.6998 mL
    5 mM 0.5176 mL 2.588 mL 5.176 mL 10.352 mL 12.94 mL
    10 mM 0.2588 mL 1.294 mL 2.588 mL 5.176 mL 6.47 mL
    50 mM 0.0518 mL 0.2588 mL 0.5176 mL 1.0352 mL 1.294 mL
    100 mM 0.0259 mL 0.1294 mL 0.2588 mL 0.5176 mL 0.647 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    松脂醇二葡萄糖苷; Pinoresinol diglucoside CFN99994 63902-38-5 C32H42O16 = 682.67 20mg QQ客服:1413575084
    8-羟基松脂醇-4'-O-beta-D-吡喃葡萄糖苷; 8-Hydroxypinoresinol-4'-O-beta-D-glucopyranoside CFN95356 102582-69-4 C26H32O12 = 536.5 5mg QQ客服:1457312923
    8-羟基松脂醇二葡萄糖苷; 8-Hydroxypinoresinol diglucoside CFN95083 112747-99-6 C32H42O17 = 698.7 5mg QQ客服:1457312923
    8-羟基松脂醇; 8-Hydroxypinoresinol CFN92432 81426-17-7 C20H22O7 = 374.4 5mg QQ客服:1457312923
    8-乙酰氧基松脂醇; 8-Acetoxypinoresinol CFN00449 81426-14-4 C22H24O8 = 416.43 5mg QQ客服:215959384
    波棱酮; Herpetone CFN90676 951677-22-8 C29H30O9 = 522.54 5mg QQ客服:2159513211
    O,O-二甲基鹅掌楸树脂醇 B; Yangambin CFN96416 13060-14-5 C24H30O8 = 446.49 10mg QQ客服:2159513211
    O,O-二甲基鹅掌楸树脂醇 A; Epiyangambin CFN96723 24192-64-1 C24H30O8 = 446.49 5mg QQ客服:3257982914
    松脂素二甲醚; Pinoresinol dimethyl ether CFN90879 29106-36-3 C22H26O6 = 386.4 20mg QQ客服:1413575084
    桉脂素; Eudesmin CFN96266 526-06-7 C22H26O6 = 386.4 20mg QQ客服:3257982914

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