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  • 过氧麦角甾醇

    Ergosterol peroxide

    产品编号 CFN98035
    CAS编号 2061-64-5
    分子式 = 分子量 C28H44O3 = 428.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Steroids
    植物来源 The herbs of Isodon eriocalyx
    产品名称 产品编号 CAS编号 包装 QQ客服
    过氧麦角甾醇 CFN98035 2061-64-5 1mg QQ客服:3257982914
    过氧麦角甾醇 CFN98035 2061-64-5 5mg QQ客服:3257982914
    过氧麦角甾醇 CFN98035 2061-64-5 10mg QQ客服:3257982914
    过氧麦角甾醇 CFN98035 2061-64-5 20mg QQ客服:3257982914
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  • Heinrich-Heine-University Düsseldorf (Germany)
  • Lodz University of Technology (Poland)
  • Melbourne University (Australia)
  • Massachusetts General Hospital (USA)
  • Universidad Industrial de Santander (Colombia)
  • University of Pretoria (South Africa)
  • Medizinische Universit?t Wien (Austria)
  • Helmholtz Zentrum München (Germany)
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • University of Lodz (Poland)
  • Kyung Hee University (Korea)
  • Kamphaengphet Rajabhat University (Thailand)
  • University of Maryland School of Medicine (USA)
  • National Cancer Center Research Institute (Japan)
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  • Phytomedicine.2018, 47:48-57
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  • ...
  • 生物活性
    Description: Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Foxo3a activity by inhibiting pAKT and c-Myc and activating pro-apoptotic protein Puma and Bax to induce cancer cell death.Ergosterol peroxide can ameliorate TGF-β1-induced activation of kidney fibroblasts, it has the potential to be developed as a therapeutic agent to prevent renal fibrosis.
    Targets: TGF-β/Smad | ERK | p38MAPK | JNK | STAT | JAK | VEGFR | Akt | CDK | Wnt/β-catenin | Antifection
    In vitro:
    Phytother Res. 2012 Jun;26(6):938-43.
    Trypanocidal activity of ergosterol peroxide from Pleurotus ostreatus.[Pubmed: 22083593]
    Chagas' disease, which is caused by the protozoan parasite Trypanosoma cruzi, is a public health problem in South America affecting millions of people, and more recently several thousands in countries where the disease is not endemic. Due to the magnitude of the problem, finding a cure for this disease remains a major challenge.
    The aim of this study is to evaluate the trypanocidal activity of Ergosterol peroxide (5α, 8α-epidioxy-22E-ergosta-6, 22-dien-3β-ol) isolated from Pleurotus ostreatus (Jacq.) P. Kumm. f. sp. Florida. The Ergosterol peroxide showed strong trypanocidal activity on the intracellular form of T. cruzi. Ergosterol peroxide had an inhibitory concentration (IC₅₀) of 6.74 µg/mL on T. cruzi, but showed no lytic action on erythrocytes and no cytotoxic effect on mammalian cells at concentrations higher than 1600 µg/mL. The interaction of Trypanosoma cruzi with Ergosterol peroxide in vitro resulted in a strong lytic activity possibly due to the disruption of the parasite membrane.
    This is the first report of trypanocidal activity, a new biological property of Ergosterol peroxide isolated from Pleurotus ostreatus (Jacq.) P. Kumm. f. sp. Florida.
    PLoS One. 2012;7(8):e44579.
    Ergosterol peroxide isolated from Ganoderma lucidum abolishes microRNA miR-378-mediated tumor cells on chemoresistance.[Pubmed: 22952996]
    Due to an altered expression of oncogenic factors and tumor suppressors, aggressive cancer cells have an intrinsic or acquired resistance to chemotherapeutic agents. This typically contributes to cancer recurrence after chemotherapy. microRNAs are short non-coding RNAs that are involved in both cell self-renewal and cancer development.
    Here we report that tumor cells transfected with miR-378 acquired properties of aggressive cancer cells. Overexpression of miR-378 enhanced both cell survival and colony formation, and contributed to multiple drug resistance. Higher concentrations of chemotherapeutic drugs were needed to induce death of miR-378-transfected cells than to induce death of control cells. We found that the biologically active component isolated from Ganoderma lucidum could overcome the drug-resistance conferred by miR-378. We purified and identified the biologically active component of Ganoderma lucidum as ergosterol peroxide.
    We demonstrated that ergosterol peroxide produced greater activity in inducing death of miR-378 cells than the GFP cells. Lower concentrations of ergosterol peroxide were needed to induce death of the miR-378-transfected cells than in the control cells. With further clinical development, ergosterol peroxide represents a promising new reagent that can overcome the drug-resistance of tumor cells.
    Bmc Cancer, 2012, 12(1):1-11.
    Inhibition of STAT3 signaling and induction of SHP1 mediate antiangiogenic and antitumor activities of ergosterol peroxide in U266 multiple myeloma cells[Pubmed: 22260501]
    Ergosterol peroxide (EP) derived from edible mushroom has been shown to exert anti-tumor activity in several cancer cells. In the present study, anti-angiogenic activity of EP was investigated with the underlying molecular mechanisms in human multiple myeloma U266 cells.
    Despite weak cytotoxicity against U266 cells, EP suppressed phosphorylation, DNA binding activity and nuclear translocalization of signal transducer and activator of transcription 3 (STAT3) in U266 cells at nontoxic concentrations. Also, EP inhibited phosphorylation of the upstream kinases Janus kinase 2 (JAK2) and Src in a time-dependent manner. Furthermore, EP increased the expression of protein tyrosine phosphatase SHP-1 at protein and mRNA levels, and conversely silencing of the SHP-1 gene clearly blocked EP-mediated STAT3 inactivation. In addition, EP significantly decreased vascular endothelial growth factor (VEGF), one of STAT3 target genes at cellular and protein levels as well as disrupted in vitro tube formation assay. Moreover, EP significantly suppressed the growth of U266 cells inoculated in female BALB/c athymic nude mice and immunohistochemistry revealed that EP effectively reduced the expression of STAT3 and CD34 in tumor sections compared to untreated control.
    These findings suggest that EP can exert antitumor activity in multiple myeloma U266 cells partly with antiangiogenic activity targeting JAK2/STAT3 signaling pathway as a potent cancer preventive agent for treatment of multiple myeloma cells.
    Pharmazie, 1989, 44(44):579-80.
    Antiviral activity of ergosterol peroxide.[Reference: WebLink]
    Antiviral activity of ergosterol peroxide.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.3326 mL 11.6632 mL 23.3263 mL 46.6527 mL 58.3158 mL
    5 mM 0.4665 mL 2.3326 mL 4.6653 mL 9.3305 mL 11.6632 mL
    10 mM 0.2333 mL 1.1663 mL 2.3326 mL 4.6653 mL 5.8316 mL
    50 mM 0.0467 mL 0.2333 mL 0.4665 mL 0.9331 mL 1.1663 mL
    100 mM 0.0233 mL 0.1166 mL 0.2333 mL 0.4665 mL 0.5832 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    麦角甾-5,24(28)-二烯-3,7,16-三醇; Ergosta-5,24(28)-diene-3,7,16-triol CFN98357 289054-34-8 C28H46O3 = 430.7 5mg QQ客服:215959384
    3Beta-羟基麦角甾-5-烯-7-酮; 3-beta-Hydroxyergost-5-en-7-one CFN99665 156767-69-0 C28H46O2 = 414.7 5mg QQ客服:1148253675
    麦角甾-4,6,8(14),22-四烯-3-酮; Ergosta-4,6,8(14),22-tetraen-3-one CFN99889 19254-69-4 C28H40O = 392.6 5mg QQ客服:215959384
    啤酒甾醇; Cerevisterol CFN98825 516-37-0 C28H46O3 = 430.7 5mg QQ客服:2159513211
    6-O-甲基啤酒甾醇; 6-O-Methylcerevisterol CFN99372 126060-09-1 C29H48O3 = 444.7 5mg QQ客服:1413575084
    3,5-二羟基麦角甾醇-7,22-二烯-6-酮; 3,5-Dihydroxyergosta-7,22-dien-6-one CFN99614 14858-07-2 C28H44O3 = 428.7 5mg QQ客服:1413575084
    3,5,9-三羟基麦角甾-7,22-二烯-6-酮; 3,5,9-Trihydroxyergosta-7,22-dien-6-one CFN97449 88191-14-4 C28H44O4 = 444.7 5mg QQ客服:1413575084
    马克甾酮A-20,22-单丙酮化物; Makisterone A 20,22-monoacetonide CFN96788 245323-24-4 C31H50O7 = 534.73 5mg QQ客服:3257982914
    (14beta,22E)-8,14-环氧基麦角甾-4,22-二烯-3,6-二酮; 8,14-Epoxyergosta-4,22-diene-3,6-dione CFN97834 1265908-20-0 C28H40O3 = 424.62 5mg QQ客服:2159513211
    3,5-环麦角甾烷-6,8(14),22-三烯; 3,5-Cycloergosta-6,8(14),22-triene CFN98257 24352-51-0 C28H42 = 378.6 5mg QQ客服:3257982914





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