• 中药标准品生产商,产品定制服务
  • 过氧麦角甾醇

    Ergosterol peroxide

    过氧麦角甾醇
    产品编号 CFN98035
    CAS编号 2061-64-5
    分子式 = 分子量 C28H44O3 = 428.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Steroids
    植物来源 The herbs of Isodon eriocalyx
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    过氧麦角甾醇 CFN98035 2061-64-5 1mg QQ客服:3257982914
    过氧麦角甾醇 CFN98035 2061-64-5 5mg QQ客服:3257982914
    过氧麦角甾醇 CFN98035 2061-64-5 10mg QQ客服:3257982914
    过氧麦角甾醇 CFN98035 2061-64-5 20mg QQ客服:3257982914
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Heinrich-Heine-University Düsseldorf (Germany)
  • Lodz University of Technology (Poland)
  • Melbourne University (Australia)
  • Massachusetts General Hospital (USA)
  • Universidad Industrial de Santander (Colombia)
  • University of Pretoria (South Africa)
  • Medizinische Universit?t Wien (Austria)
  • Helmholtz Zentrum München (Germany)
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • University of Lodz (Poland)
  • Kyung Hee University (Korea)
  • Kamphaengphet Rajabhat University (Thailand)
  • University of Maryland School of Medicine (USA)
  • National Cancer Center Research Institute (Japan)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Breast Cancer.2015, 18(2):112-118
  • The Journal of Internal Korean Medicine2015, 36(4):486-497
  • Food Analytical Methods2017, 10:3225–3234
  • Onco Targets Ther.2017, 10:3467-3474
  • Current Pharmaceutical Analysis2017, 13(5)
  • Preprints2017, 2017120176
  • Srinagarind Medical Journal2017, 32(1)
  • Front Pharmacol.2017, 8:205
  • Food Res Int.2018, 106:909-919
  • Lab Chip.2018, 18(6):971-978
  • Chem Biol Interact.2018, 290:44-51
  • Sci Adv.2018, 4(10)
  • Sci Rep. 2018, 462(8)
  • Phytomedicine.2018, 47:48-57
  • J Chromatogr B Analyt Technol Biomed Life Sci.2019, 1126-1127:121743
  • Molecules.2019, 24(6):E1177
  • Molecules.2019, 24(7):E1290
  • Exp Biol Med (Maywood).2019, 244(18):1665-1679
  • J Mol Histol.2019, 50(4):343-354
  • Phytomedicine.2019, 58:152893
  • J Clin Med.2019, 8(10):E1664
  • Br J Pharmacol.2020, 10.1111
  • J Ethnopharmacol.2020, 249:112396
  • ...
  • 生物活性
    Description: Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Foxo3a activity by inhibiting pAKT and c-Myc and activating pro-apoptotic protein Puma and Bax to induce cancer cell death.Ergosterol peroxide can ameliorate TGF-β1-induced activation of kidney fibroblasts, it has the potential to be developed as a therapeutic agent to prevent renal fibrosis.
    Targets: TGF-β/Smad | ERK | p38MAPK | JNK | STAT | JAK | VEGFR | Akt | CDK | Wnt/β-catenin | Antifection
    In vitro:
    Phytother Res. 2012 Jun;26(6):938-43.
    Trypanocidal activity of ergosterol peroxide from Pleurotus ostreatus.[Pubmed: 22083593]
    Chagas' disease, which is caused by the protozoan parasite Trypanosoma cruzi, is a public health problem in South America affecting millions of people, and more recently several thousands in countries where the disease is not endemic. Due to the magnitude of the problem, finding a cure for this disease remains a major challenge.
    METHODS AND RESULTS:
    The aim of this study is to evaluate the trypanocidal activity of Ergosterol peroxide (5α, 8α-epidioxy-22E-ergosta-6, 22-dien-3β-ol) isolated from Pleurotus ostreatus (Jacq.) P. Kumm. f. sp. Florida. The Ergosterol peroxide showed strong trypanocidal activity on the intracellular form of T. cruzi. Ergosterol peroxide had an inhibitory concentration (IC₅₀) of 6.74 µg/mL on T. cruzi, but showed no lytic action on erythrocytes and no cytotoxic effect on mammalian cells at concentrations higher than 1600 µg/mL. The interaction of Trypanosoma cruzi with Ergosterol peroxide in vitro resulted in a strong lytic activity possibly due to the disruption of the parasite membrane.
    CONCLUSIONS:
    This is the first report of trypanocidal activity, a new biological property of Ergosterol peroxide isolated from Pleurotus ostreatus (Jacq.) P. Kumm. f. sp. Florida.
    PLoS One. 2012;7(8):e44579.
    Ergosterol peroxide isolated from Ganoderma lucidum abolishes microRNA miR-378-mediated tumor cells on chemoresistance.[Pubmed: 22952996]
    Due to an altered expression of oncogenic factors and tumor suppressors, aggressive cancer cells have an intrinsic or acquired resistance to chemotherapeutic agents. This typically contributes to cancer recurrence after chemotherapy. microRNAs are short non-coding RNAs that are involved in both cell self-renewal and cancer development.
    METHODS AND RESULTS:
    Here we report that tumor cells transfected with miR-378 acquired properties of aggressive cancer cells. Overexpression of miR-378 enhanced both cell survival and colony formation, and contributed to multiple drug resistance. Higher concentrations of chemotherapeutic drugs were needed to induce death of miR-378-transfected cells than to induce death of control cells. We found that the biologically active component isolated from Ganoderma lucidum could overcome the drug-resistance conferred by miR-378. We purified and identified the biologically active component of Ganoderma lucidum as ergosterol peroxide.
    CONCLUSIONS:
    We demonstrated that ergosterol peroxide produced greater activity in inducing death of miR-378 cells than the GFP cells. Lower concentrations of ergosterol peroxide were needed to induce death of the miR-378-transfected cells than in the control cells. With further clinical development, ergosterol peroxide represents a promising new reagent that can overcome the drug-resistance of tumor cells.
    Bmc Cancer, 2012, 12(1):1-11.
    Inhibition of STAT3 signaling and induction of SHP1 mediate antiangiogenic and antitumor activities of ergosterol peroxide in U266 multiple myeloma cells[Pubmed: 22260501]
    Ergosterol peroxide (EP) derived from edible mushroom has been shown to exert anti-tumor activity in several cancer cells. In the present study, anti-angiogenic activity of EP was investigated with the underlying molecular mechanisms in human multiple myeloma U266 cells.
    METHODS AND RESULTS:
    Despite weak cytotoxicity against U266 cells, EP suppressed phosphorylation, DNA binding activity and nuclear translocalization of signal transducer and activator of transcription 3 (STAT3) in U266 cells at nontoxic concentrations. Also, EP inhibited phosphorylation of the upstream kinases Janus kinase 2 (JAK2) and Src in a time-dependent manner. Furthermore, EP increased the expression of protein tyrosine phosphatase SHP-1 at protein and mRNA levels, and conversely silencing of the SHP-1 gene clearly blocked EP-mediated STAT3 inactivation. In addition, EP significantly decreased vascular endothelial growth factor (VEGF), one of STAT3 target genes at cellular and protein levels as well as disrupted in vitro tube formation assay. Moreover, EP significantly suppressed the growth of U266 cells inoculated in female BALB/c athymic nude mice and immunohistochemistry revealed that EP effectively reduced the expression of STAT3 and CD34 in tumor sections compared to untreated control.
    CONCLUSIONS:
    These findings suggest that EP can exert antitumor activity in multiple myeloma U266 cells partly with antiangiogenic activity targeting JAK2/STAT3 signaling pathway as a potent cancer preventive agent for treatment of multiple myeloma cells.
    Pharmazie, 1989, 44(44):579-80.
    Antiviral activity of ergosterol peroxide.[Reference: WebLink]
    Antiviral activity of ergosterol peroxide.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.3326 mL 11.6632 mL 23.3263 mL 46.6527 mL 58.3158 mL
    5 mM 0.4665 mL 2.3326 mL 4.6653 mL 9.3305 mL 11.6632 mL
    10 mM 0.2333 mL 1.1663 mL 2.3326 mL 4.6653 mL 5.8316 mL
    50 mM 0.0467 mL 0.2333 mL 0.4665 mL 0.9331 mL 1.1663 mL
    100 mM 0.0233 mL 0.1166 mL 0.2333 mL 0.4665 mL 0.5832 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    麦角甾-5,24(28)-二烯-3,7,16-三醇; Ergosta-5,24(28)-diene-3,7,16-triol CFN98357 289054-34-8 C28H46O3 = 430.7 5mg QQ客服:215959384
    3Beta-羟基麦角甾-5-烯-7-酮; 3-beta-Hydroxyergost-5-en-7-one CFN99665 156767-69-0 C28H46O2 = 414.7 5mg QQ客服:1148253675
    麦角甾-4,6,8(14),22-四烯-3-酮; Ergosta-4,6,8(14),22-tetraen-3-one CFN99889 19254-69-4 C28H40O = 392.6 5mg QQ客服:215959384
    啤酒甾醇; Cerevisterol CFN98825 516-37-0 C28H46O3 = 430.7 5mg QQ客服:2159513211
    6-O-甲基啤酒甾醇; 6-O-Methylcerevisterol CFN99372 126060-09-1 C29H48O3 = 444.7 5mg QQ客服:1413575084
    3,5-二羟基麦角甾醇-7,22-二烯-6-酮; 3,5-Dihydroxyergosta-7,22-dien-6-one CFN99614 14858-07-2 C28H44O3 = 428.7 5mg QQ客服:1413575084
    3,5,9-三羟基麦角甾-7,22-二烯-6-酮; 3,5,9-Trihydroxyergosta-7,22-dien-6-one CFN97449 88191-14-4 C28H44O4 = 444.7 5mg QQ客服:1413575084
    马克甾酮A-20,22-单丙酮化物; Makisterone A 20,22-monoacetonide CFN96788 245323-24-4 C31H50O7 = 534.73 5mg QQ客服:3257982914
    (14beta,22E)-8,14-环氧基麦角甾-4,22-二烯-3,6-二酮; 8,14-Epoxyergosta-4,22-diene-3,6-dione CFN97834 1265908-20-0 C28H40O3 = 424.62 5mg QQ客服:2159513211
    3,5-环麦角甾烷-6,8(14),22-三烯; 3,5-Cycloergosta-6,8(14),22-triene CFN98257 24352-51-0 C28H42 = 378.6 5mg QQ客服:3257982914

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产