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  • 麦角甾-4,6,8(14),22-四烯-3-酮

    Ergosta-4,6,8(14),22-tetraen-3-one

    麦角甾-4,6,8(14),22-四烯-3-酮
    产品编号 CFN99889
    CAS编号 19254-69-4
    分子式 = 分子量 C28H40O = 392.6
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Steroids
    植物来源 The fruit body of Polyporus umbellatus
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    麦角甾-4,6,8(14),22-四烯-3-酮 CFN99889 19254-69-4 1mg QQ客服:1413575084
    麦角甾-4,6,8(14),22-四烯-3-酮 CFN99889 19254-69-4 5mg QQ客服:1413575084
    麦角甾-4,6,8(14),22-四烯-3-酮 CFN99889 19254-69-4 10mg QQ客服:1413575084
    麦角甾-4,6,8(14),22-四烯-3-酮 CFN99889 19254-69-4 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Plant Foods Hum Nutr.2021, 76(4):472-477.
  • Heliyon.2022, e12337.
  • ACS Pharmacol. Transl. Sci.2022, 5,7,479-490
  • J Ethnopharmacol.2022, 289:115018.
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  • Antioxidants.2022, 11(3):491.
  • Int J Mol Sci.2020, 21(24):9369.
  • Plants (Basel).2021, 10(4):702.
  • Oxid Med Cell Longev.2021, 2021:4883398.
  • Planta Med.2018, 84(15):1101-1109
  • Auburn University2015, 1-58
  • The Korea Journal of Herbology2016, 29-35
  • Oncology Letters2018, 4690-4696
  • Int J Mol Sci.2019, 21(1):E265
  • Processes2021, 9(11),2065.
  • Journal of Oil Palm Research2019, 31(2):238-247
  • J Nat Med.2017, 71(2):457-462
  • J Cell Mol Med.2023, jcmm.18071.
  • ...
  • 生物活性
    Description: Ergosta-4,6,8(14),22-tetraen-3-one has cytotoxic activity against human gastric cancer cell, it can induce G2/M cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells, these results would be useful for the further utilization of many medicinal fungi in cancer treatment. Ergosta-4,6,8(14),22-tetraen-3-one treatment can confer protection against early renal injury in a rat model of aristolochic acid (AA) nephropathy, early administration of it may prevent the progression of renal injury and the subsequent renal fibrosis in AA nephropathy. It has inhibitory activity of nitric oxide production in RAW 264.7 cells stimulated by lipopolysaccharide was examined and shows a potential activity with the IC(50) value of 28.96 microM.
    Targets: Bcl-2/Bax | p53 | Caspase | PARP | NO
    In vitro:
    Biochim Biophys Acta. 2011 Apr;1810(4):384-90.
    Ergosta-4,6,8(14),22-tetraen-3-one induces G2/M cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells.[Pubmed: 21241775]
    Mushrooms have been used in Asia as traditional foods and medicines for a long time. Ergosta-4,6,8(14),22-tetraen-3-one (ergone) is one of the well-known bioactive steroids, which exists widely in various medicinal fungi such as Polyporus umbellatus, Russula cyanoxantha, and Cordyceps sinensis. Ergone has been demonstrated to possess cytotoxic activity. However, the molecular mechanisms by which ergone exerts its cytotoxic activity are currently unknown.
    METHODS AND RESULTS:
    In the present study, ergone possessed a remarkable anti-proliferative activity toward human hepatocellular carcinoma HepG2 cells. We assayed the cell cycle by flow cytometry using PI staining; investigated the exposure of phosphatidylserine at the outer layer of the cytoplasmic membrane by the FITC-annexin V/PI staining; observed the nuclear fragmentation by Hoechst 33258 staining and studied the protein expression of Bax, Bcl-2, p-53, procaspase-3, -8, -9, PARP and cleaved PARP by Western blotting analysis. Cells treated with ergone showed typical markers of apoptosis: G2/M cell cycle arrest, chromatin condensation, nuclear fragmentation, and phosphatidylserine exposure. Furthermore, PARP-cleavage; activation of caspase-3, -8, -9; up-regulation of Bax and down-regulation of Bcl-2 were observed in HepG2 cells treated with ergone, which show that both the intrinsic and extrinsic apoptotic pathways are involved in ergone-induced apoptosis in HepG2 cells. Ergosta-4,6,8(14),22-tetraen-3-one induces G2/M cell cycle arrest and apoptosis in HepG2 cells in a caspase-dependent manner.
    CONCLUSIONS:
    In this study, we reported for the first time that ergone-induced apoptosis through activating the caspase. These results would be useful for the further utilization of many medicinal fungi in cancer treatment.
    Nat Prod Res. 2008;22(10):901-6
    Ergosta-4,6,8(14),22-tetraen-3-one from Vietnamese Xylaria sp. possessing inhibitory activity of nitric oxide production.[Pubmed: 18626826 ]

    METHODS AND RESULTS:
    From the methanolic extract of Xylaria sp. collected in Vietnam, a fluorescent constituent, Ergosta-4,6,8(14),22-tetraen-3-one (1) was isolated and elucidated by the combination of 2D NMR, high resolution MS, IR and UV spectroscopy. Its inhibitory activity of nitric oxide production in RAW 264.7 cells stimulated by lipopolysaccharide was examined and showed a potential activity with the IC(50) value of 28.96 microM.
    Bull. Korean Chem. Soc., 2005, 26(9):1464-6.
    Cytotoxic Activity of Ergosta-4,6,8(14),22-tetraen-3-one from the Sclerotia of Polyporus umbellatus.[Reference: WebLink]
    Cytotoxic Activity of Ergosta-4,6,8(14),22-tetraen-3-one from the Sclerotia of Polyporus umbellatus.
    In vivo:
    J Pharm Pharmacol. 2011 Dec;63(12):1581-6.
    Ergosta-4,6,8(14),22-tetraen-3-one isolated from Polyporus umbellatus prevents early renal injury in aristolochic acid-induced nephropathy rats.[Pubmed: 22060289]
    Aristolochic acid (AA) nephropathy, first reported as Chinese herbs nephropathy, is a rapidly progressive tubulointerstitial nephropathy that results in severe anemia, interstitial fibrosis and end-stage renal disease. Tubulointerstitial injury was studied in a rat model of AA nephropathy to determine whether Ergosta-4,6,8(14),22-tetraen-3-one (ergone) treatment prevents early renal injury in rats with aristolochic acid I-induced nephropathy.
    METHODS AND RESULTS:
    Early renal injury via renal interstitial fibrosis was induced in rats by administration of aristolochic acid I (AAI) solution intragastrically for 8 weeks. Ninety-six rats were randomly divided into four groups (n = 24/group): (1) control (2) AAI (3) AAI + ergone (10 mg/kg) and (4) AAI + ergone (20 mg/kg). Blood and urine samples were collected and rat were sacrificed for histological assessment of the kidneys on at the end of weeks 2, 4, 6 and 8. AAI caused progressive elevation of blood urea nitrogen, creatinine, potassium, sodium, chlorine, proteinuria and urinary N-acetyl-β-D-glucosaminidase (NAG). Ergone suppressed elevation of blood urea, nitrogen, creatinine, proteinuria and urinary NAG to some degree, but the AAI-ergone-treated group did not differ from AAI-treated group for body weight, serum potassium, sodium and chlorine. The progress of the lesions in the kidney after AAI administration was also observed by histopathological examinations, but kidneys from rats of AAI-ergone-treated group displayed fewer lesions.
    CONCLUSIONS:
    Ergone treatment conferred protection against early renal injury in a rat model of AA nephropathy. Early administration of ergone may prevent the progression of renal injury and the subsequent renal fibrosis in AA nephropathy.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.5471 mL 12.7356 mL 25.4712 mL 50.9424 mL 63.678 mL
    5 mM 0.5094 mL 2.5471 mL 5.0942 mL 10.1885 mL 12.7356 mL
    10 mM 0.2547 mL 1.2736 mL 2.5471 mL 5.0942 mL 6.3678 mL
    50 mM 0.0509 mL 0.2547 mL 0.5094 mL 1.0188 mL 1.2736 mL
    100 mM 0.0255 mL 0.1274 mL 0.2547 mL 0.5094 mL 0.6368 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    过氧麦角甾醇; Ergosterol peroxide CFN98035 2061-64-5 C28H44O3 = 428.7 10mg QQ客服:3257982914
    过氧麦角甾醇 3-O-beta-D-吡喃葡萄糖苷; Ergosterol peroxide glucoside CFN99458 140447-22-9 C34H54O8 = 590.8 5mg QQ客服:215959384
    表油菜素内酯; Epibrassinolide CFN80268 72962-43-7 C28H48O6 = 480.34 5mg QQ客服:2056216494
    猪苓酮A; Polyporusterone A CFN91564 141360-88-5 C28H46O6 = 478.7 10mg QQ客服:1457312923
    猪苓酮B; Polyporusterone B CFN91703 141360-89-6 C28H44O6 = 476.7 10mg QQ客服:1457312923
    菜油甾醇; Campesterol CFN92204 474-62-4 C28H48O = 400.7 10mg QQ客服:3257982914
    菜籽甾醇; Brassicasterol CFN90471 474-67-9 C28H46O = 398.66 5mg QQ客服:215959384
    星鱼甾醇; Stellasterol CFN98267 2465-11-4 C28H46O = 398.7 20mg QQ客服:1457312923
    麦角甾-7,22-二烯-3-酮; Ergosta-7,22-dien-3-one CFN96785 32507-77-0 C28H44O = 396.65 5mg QQ客服:2056216494
    麦角固醇; 麦角甾醇; Ergosterol CFN98980 57-87-4 C28H44O = 396.7 20mg QQ客服:2056216494

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