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  • (-)-表阿夫儿茶精

    (-)-Epiafzelechin

    (-)-表阿夫儿茶精
    产品编号 CFN98271
    CAS编号 24808-04-6
    分子式 = 分子量 C15H14O5 = 274.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The herbs of Celastrus orbiculatus
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    (-)-表阿夫儿茶精 CFN98271 24808-04-6 1mg QQ客服:1457312923
    (-)-表阿夫儿茶精 CFN98271 24808-04-6 5mg QQ客服:1457312923
    (-)-表阿夫儿茶精 CFN98271 24808-04-6 10mg QQ客服:1457312923
    (-)-表阿夫儿茶精 CFN98271 24808-04-6 20mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
  • University Medical Center Mainz (Germany)
  • Chinese University of Hong Kong (China)
  • Srinakharinwirot University (Thailand)
  • Aveiro University (Portugal)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Korean J. of Horticultural Sci. & Tech. 2017, 793-804
  • Natural Product Communications2021, 16(9):1-10.
  • Oncotarget.2017, 9(3):4161-4172
  • Molecules.2019, 24(20):3755
  • Phytochemistry Letters2015, 243-247
  • Food Chem. 2020, 320:126530
  • PLoS One.2022, 17(6):e0268505.
  • Appl. Sci.2021, 11(24),12080
  • Arch Biochem Biophys.2020, 687:108363.
  • Int. J. of Food Properties2017, S108-S118
  • PLoS One.2018, 13(3):e0193386
  • Arch Pharm Res.2015, 38(6):1080-9
  • Front Immunol. 2020, 11:62.
  • Cancer Manag Res.2019, 11:483-500
  • J Health Sci Med Res.2023, 31584.
  • Phytomedicine.2015, 22(14):1262-8
  • The Japan Society for Analytical Chemistry2017, 613-617
  • Oncol Rep.2021, 46(2):166.
  • J Food Sci.2022, 87(11):4905-4916.
  • Plants (Basel).2023, 12(22):3877.
  • Auburn University2015, 1-58
  • Chem Biol Interact.2019, 298:1-7
  • Foods.2021, 10(11):2754.
  • ...
  • 生物活性
    Description: (-)-Epiafzelechin exhibits significant anti-inflammatory activity on carrageenin-induced mouse paw edema, it exhibits a dose-dependent inhibition on the COX activity with an IC50 value of 15 microM, it exhibits about 3-fold weaker inhibitory potency on the enzyme activity than indomethacin as a positive control. (-)-Epicatechin shows zero and/or the lowest activities against pancreatic lipase (IC50 > 20 microM). Epiafzelechin has antioxidant properties.
    Targets: COX
    In vitro:
    J Agric Food Chem. 2005 Jun 1;53(11):4593-8.
    Inhibitory effects of oolong tea polyphenols on pancreatic lipase in vitro.[Pubmed: 15913331]
    Fifty-four polyphenols isolated from tea leaves were evaluated for their inhibitory activities against pancreatic lipase, the key enzyme of lipid absorption in the gut.
    METHODS AND RESULTS:
    (-)-Epigallocatechin 3-O-gallate (EGCG), which is one of major polyphenols in green tea, showed lipase inhibition with an IC50 of 0.349 microM. Moreover, flavan-3-ol digallate esters, such as (-)-epigallocatechin-3,5-digallate, showed higher activities of inhibition on lipase with an IC50 of 0.098 microM. On the other hand, nonesterified flavan-3-ols, such as (+)-catechin, (-)-epicatechin, (+)-gallocatechin, and (-)-epigallocatechin, showed zero and/or the lowest activities against pancreatic lipase (IC50 > 20 microM). These data suggested that the presence of galloyl moieties within the structure was required for enhancement of pancreatic lipase inhibition. It is well-known that flavan-3-ols are polymerized by polyphenol oxidase and/or heating in a manufacturing process of oolong tea. Oolonghomobisflavans A and B and oolongtheanin 3'-O-gallate, which are typical in oolong tea leaves, showed strong inhibitory activities with IC50 values of 0.048, 0.108, and 0.068 microM, respectively, even higher than that of EGCG. The oolong tea polymerized polyphenols (OTPP) were prepared for the assay from oolong tea extract, from which the preparation effectively subtracted the zero and/or less-active monomeric flavan-3-ols by preparative high-performance liquid chromatography. The weight-average molecular weight (Mw) and number-average molecular-weight (Mn) values of OTPP were 2017 and 903, respectively, by using gel permeation choromatography. OTPP showed a 5-fold stronger inhibition against pancreatic lipase (IC50 = 0.28 microg/mL) by comparison with that of the tannase-treated OTPP (IC50 = 1.38 microg/mL).
    CONCLUSIONS:
    These data suggested that the presence of galloyl moieties within their chemical structures and/or the polymerization of flavan-3-ols were required for enhancement of pancreatic lipase inhibition.
    Nat Prod Res . 2018 Feb;32(4):453-456.
    Antioxidant phenolic compounds from the rhizomes of Astilbe rivularis[Pubmed: 28361551]
    Abstract The rhizomes of Astilbe rivularis, commonly known as 'Thulo Okhati' are widely used in Nepal as tonic for uterine and menstrual disorders. In our preliminary study, the 70% MeOH extract of the rhizomes showed potent antioxidant activity. Hence, present study was aimed for the isolation of potent antioxidant constituents. Bergenin (1), 11-O-galloylbergenin (2), (+)-catechin (3), (-)-catechin (4), (-)-afzelechin (5), (-)-epiafzelechin (6) and 2-(β-D-glucopyranosyloxy)-4-hydroxylbenzenacetonitrile (7) were isolated from the rhizomes. Structures of these compounds were elucidated on the basis of spectroscopic methods. All these isolated compounds were evaluated for their in vitro antioxidant activity by 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay. 11-O-Galloylbergenin (2), (+)-catechin (3), (-)-catechin (4), (-)-afzelechin (5) and (-)-epiafzelechin (6) showed potent antioxidant activity. Keywords: Astilbe rivularis; Thulo Okhati; antioxidant activity; bergenin.
    In vivo:
    Planta Med. 1999 Jun;65(5):460-2.
    (-)-Epiafzelechin: cyclooxygenase-1 inhibitor and anti-inflammatory agent from aerial parts of Celastrus orbiculatus.[Pubmed: 10418338]

    METHODS AND RESULTS:
    An inhibitor of cyclooxygenase (COX)-1 activity of prostaglandin H2 synthase was isolated from aerial parts of Celastrus orbiculatus Thunb. (Celastraceae), an oriental folk medicine for rheumatoid arthritis by activity-guided column chromatographic methods. The COX inhibitor was identified as (-)-epiafzelechin, a member of flavan-3-ols by the structural analysis with HR-EI-mass, 1H-NMR and 13C-NMR spectral data.
    CONCLUSIONS:
    The compound exhibited a dose-dependent inhibition on the COX activity with an IC50 value of 15 microM. (-)-Epiafzelechin exhibited about 3-fold weaker inhibitory potency on the enzyme activity than indomethacin as a positive control. (-)-Epiafzelechin exhibited significant anti-inflammatory activity on carrageenin-induced mouse paw edema when the compound (100 mg/kg) was orally administrated at 1 h before carrageenin treatment.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.6456 mL 18.2282 mL 36.4564 mL 72.9129 mL 91.1411 mL
    5 mM 0.7291 mL 3.6456 mL 7.2913 mL 14.5826 mL 18.2282 mL
    10 mM 0.3646 mL 1.8228 mL 3.6456 mL 7.2913 mL 9.1141 mL
    50 mM 0.0729 mL 0.3646 mL 0.7291 mL 1.4583 mL 1.8228 mL
    100 mM 0.0365 mL 0.1823 mL 0.3646 mL 0.7291 mL 0.9114 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    乙酰化表没食子儿茶素没食子酸酯; Epigallocatechin gallate octaacetate CFN91644 148707-39-5 C38H34O19 = 794.7 5mg QQ客服:2159513211
    表没食子儿茶素3-O-(3''-O-甲基)没食子酸酯; (-)-Epigallocatechin-3-(3''-O-methyl) gallate CFN92081 83104-87-4 C23H20O11 = 472.4 10mg QQ客服:1413575084
    (-)-表阿夫儿茶精; (-)-Epiafzelechin CFN98271 24808-04-6 C15H14O5 = 274.3 10mg QQ客服:1413575084
    3-羟基-4',5,7-三甲氧基黄烷; 3-Hydroxy-4',5,7-trimethoxyflavan CFN95680 3143-21-3 C18H20O5 = 316.4 5mg QQ客服:215959384
    3,3'-二羟基-4',5,7-三甲氧基黄烷; 3,3'-Dihydroxy-4',5,7-trimethoxyflavan CFN95679 97914-22-2 C18H20O6 = 332.4 5mg QQ客服:2159513211
    3,4'-二羟基-3',5,7-三甲氧基黄烷; 3,4'-Dihydroxy-3,5',7-trimethoxyflavan CFN97558 97914-19-7 C18H20O6 = 332.4 5mg QQ客服:2056216494
    (2R-cis)-2-(1,3-苯并二恶茂-5-基)-3,4-二氢-5,7-二甲氧基-2H-1-苯并吡喃-3-醇; 3-Hydroxy-5,7-dimethoxy-3',4'-methylenedioxyflavan CFN99685 162602-04-2 C18H18O6 = 330.3 5mg QQ客服:3257982914
    表儿茶素; Epicatechin CFN98781 490-46-0 C15H14O6 = 290.3 20mg QQ客服:2056216494
    (-)-表儿茶精五乙酸酯; Epicatechin pentaacetate CFN98020 20194-41-6 C25H24O11 = 500.5 5mg QQ客服:1457312923
    表儿茶素没食子酸酯; (-)-Epicatechin gallate CFN99570 1257-08-5 C22H18O10 = 442.38 20mg QQ客服:2159513211

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