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  • 血竭素高氯酸盐

    Dracorhodin perchlorate

    血竭素高氯酸盐
    产品编号 CFN90486
    CAS编号 125536-25-6
    分子式 = 分子量 C17H15ClO7 = 366.75
    产品纯度 >=98%
    物理属性 Red powder
    化合物类型 Flavonoids
    植物来源 The herbs of Daemonorops draco Bl.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    血竭素高氯酸盐 CFN90486 125536-25-6 10mg QQ客服:2056216494
    血竭素高氯酸盐 CFN90486 125536-25-6 20mg QQ客服:2056216494
    血竭素高氯酸盐 CFN90486 125536-25-6 50mg QQ客服:2056216494
    血竭素高氯酸盐 CFN90486 125536-25-6 100mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Sanford Burnham Medical Research Institute (USA)
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  • University of Padjajaran (Indonesia)
  • Medizinische Universit?t Wien (Austria)
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  • Chinese University of Hong Kong (China)
  • Yale University (USA)
  • Universitas islam negeri Jakarta (Indonesia)
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  • Korea Institute of Oriental Medicine (Korea)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Bioorg Med Chem.2018, 26(14):4201-4208
  • Molecules.2019, 24(10):E1926
  • J Ethnopharmacol.2023, 317:116789.
  • Int J Mol Sci.2022, 23(10):5468.
  • Nutrients.2019, 11(6):E1380
  • QASCF2022, 14(4).
  • SBRAS2016, 12
  • Int J Mol Sci.2018, 19(9):E2601
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  • Process Biochemistry2019, 87:213-220
  • Food Chem Toxicol.2023, 176:113802.
  • Food Bioscience2023, 56:103311.
  • J Agric Food Chem.2019, 67(27):7748-7754
  • Research Square2021, March 3rd.
  • The Korea Journal of Herbology2019, 34(2):25-32
  • Turk J Med Sci.2023 53: 1312-1320.
  • Separations2021, 8(7),90.
  • Tokyo Pharmaceutical University2020, 500001431953.
  • International. J. of Food Properties 2017, 20:S131-S140
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  • ...
  • 生物活性
    Description: Dracorhodin perchlorate inhibits cell growth, and induces apoptosis in fibroblasts in a dose-and time-dependent manner, arresting cell cycle at G1 phase, may as a candidate for anti-breast cancer. Dracorhodin perchlorate can inhibit high glucose-induced serum and glucocorticoid induced protein kinase 1 (SGK1) and fibronectin(FN) expression in human mesangial cells, and this may be part of the mechanism of preventing and treating renal fibrosis of DN.
    Targets: Caspase | PI3K | Akt | NF-kB | p53 | Bcl-2/Bax | p21 | TNF-α | PARP | MMP(e.g.TIMP) | P450 (e.g. CYP17)
    In vitro:
    Eur J Pharmacol. 2014 Apr 5;728:82-92.
    Dracorhodin perchlorate induces apoptosis in primary fibroblasts from human skin hypertrophic scars via participation of caspase-3.[Pubmed: 24525335]
    Hypertrophic scar (HS) is an abnormally proliferative disorder characterized by excessive proliferation of fibroblasts and redundant deposition of extracellular matrix. An unbalance between fibroblast proliferation and apoptosis has been assumed to play an important role in HS formation.
    METHODS AND RESULTS:
    To explore the regulative effects of dracorhodin perchlorate (Dp), one of the derivants of dracorhodin that is a major constituent in the traditional Chinese medicine, on primary fibroblasts from human skin hypertrophic scars, 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay and flow cytometric analysis were respectively used to evaluate the inhibitory effect of Dp on the cells and to determine cell cycle distribution. Additionally, cellular apoptosis was separately detected with Hoechst 33258 staining and terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling (TUNEL) assay. The expression levels of caspase-3 mRNA and protein were respectively measured with reverse transcription-polymerase chain reaction and western blot analysis, and caspase-3 activity were determined using a colorimetric assay kit. The results showed that Dp significantly inhibited cell growth, and induced apoptosis in fibroblasts in a dose-and time-dependent manner, arresting cell cycle at G1 phase. Additionally, Dp slightly up-regulated caspase-3 mRNA expression in fibroblasts, but significantly down-regulated caspase-3 protein expression in a dose- and time-dependent manner, and concurrently elevated caspase-3 activity.
    CONCLUSIONS:
    Taken together, these data indicated that Dp could effectively inhibit cell proliferation, and induced cell cycle arrest and apoptosis in fibroblasts, at least partially via modulation of caspase-3 expression and its activity, which suggests that Dp is an effective and potential candidate to develop for HS treatment.
    Zhongguo Zhong Yao Za Zhi. 2010 Aug;35(15):1996-2000.
    Dracorhodin perchlorate inhibit high glucose induce serum and glucocorticoid induced protein kinase 1 and fibronectin expression in human mesangial cells.[Pubmed: 20931854]
    To investigate the effect of dracorhodin perchlorate (DP) on inhibiting high glucose-induced serum and glucocorticoid induced protein kinase 1 (SGK1) and fibronectin (FN) expression in human mesangial cells (HMC), and its mechanism of prevention and treatment on renal fibrosis in diabetic nephropathy (DN) .
    METHODS AND RESULTS:
    The HMC were divided into normal glucose group (NG group, 5.5 mmol x L(-1) D-glucose), normal glucose +low DP group (NG + LDP group, 5.5 mmol x L(-1) D-glucose +7.5 micromol x L(-1) DP), normal glucose +high DP group (NG + HDP group, 5.5 mmol x L(-1) D-glucose + 15 micromol x L(-1) DP), high glucose group (HG group,25 mmol x L(-1) D-glucose), high glucose +low DP group (HG + LDP group, 25 mmol x L(-1) D-glucose + 7.5 micromol x L(-1) DP)and high glucose +high DP group (HG +HDP group, 25 mmol x L(-1) D-glucose + 15 micromol x L(-1) DP). Each group was examined at 24 hours. The levels of SGK1 and FN mRNA was detected by real-time fluorescence quantitative PCR,and the expression of SGK1 and FN protein was detected by Western blot or indirect immunofluorescence. A basal level of SGK1 and FN in HMC were detected in NG group, and the level of SGK1 and FN mRNA and protein were not evidently different compared to that of NG group adding 7.5 micromol x L(-1) DP for 24 hours. On the other hand, the levels of SGK1 and FN mRNA and protein were obviously decreased by adding 15 micromol x L(-1) DP for 24 hours. Compared to NG group, the levels of SGK1 and FN mRNA and protein were increased in HG group after stimulating for 24 hours (P < 0.01). Compared to HG group, the level of SGK1 and FN mRNA and protein were evidently reduced in HG + LDP and HG + HDP groups by adding 7.5 micromol x L(-1) DP and 15 micromol x L(-1) DP for 24 hours (P < 0.01).
    CONCLUSIONS:
    Dracorhodin perchlorate can inhibit high glucose-induced serum and glucocorticoid induced protein kinase 1 (SGK1) and fibronectin(FN) expression in human mesangial cells, and this may be part of the mechanism of preventing and treating renal fibrosis of DN.
    J Huazhong Univ Sci Technolog Med Sci. 2011 Apr;31(2):215-9.
    Dracorhodin perchlorate suppresses proliferation and induces apoptosis in human prostate cancer cell line PC-3.[Pubmed: 21505988]

    METHODS AND RESULTS:
    The growth inhibition and pro-apoptosis effects of dracorhodin perchlorate on human prostate cancer PC-3 cell line were examined. After administration of 10-80 μmol/L dracorhodin perchlorate for 12-48 h, cell viability of PC-3 cells was measured by MTT colorimetry. Cell proliferation ability was detected by colony formation assay. Cellular apoptosis was inspected by acridine orange-ethidium bromide fluorescent staining, Hoechst 33258 fluorescent staining, and flow cytometry (FCM) with annexin V-FITC/propidium iodide dual staining. The results showed that dracorhodin perchlorate inhibited the growth of PC-3 in a dose- and time-dependent manner. IC50 of dracorhodin perchlorate on PC-3 cells at 24 h was 40.18 μmol/L. Cell clone formation rate was decreased by 86% after treatment with 20 μmol/L of dracorhodin perchlorate. Some cells presented the characteristic apoptotic changes. The cellular apoptotic rates induced by 10-40 μmol/L dracorhodin perchlorate for 24 h were 8.43% to 47.71% respectively.
    CONCLUSIONS:
    It was concluded that dracorhodin perchlorate significantly inhibited the growth of PC-3 cells by suppressing proliferation and inducing apoptosis of the cells.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.7267 mL 13.6333 mL 27.2665 mL 54.5331 mL 68.1663 mL
    5 mM 0.5453 mL 2.7267 mL 5.4533 mL 10.9066 mL 13.6333 mL
    10 mM 0.2727 mL 1.3633 mL 2.7267 mL 5.4533 mL 6.8166 mL
    50 mM 0.0545 mL 0.2727 mL 0.5453 mL 1.0907 mL 1.3633 mL
    100 mM 0.0273 mL 0.1363 mL 0.2727 mL 0.5453 mL 0.6817 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    氯化矢车菊素-3-O-阿拉伯糖苷; Cyanidin-3-O-arabinoside chloride CFN92041 111613-04-8 C20H19ClO10 = 454.8 10mg QQ客服:215959384
    矢车菊素-3-O-鼠李糖苷氯化物; Cyanidin-3-O-rhamnoside chloride CFN91188 38533-30-1 C21H21ClO10 = 468.8 5mg QQ客服:2159513211
    氯化失车菊素-3-O-半乳糖苷; Cyanidin-3-O-galactoside chloride CFN92040 27661-36-5 C21H21ClO11 = 484.9 10mg QQ客服:215959384
    氯化失车菊素-3-O-葡萄糖苷; Cyanidin-3-O-glucoside chloride CFN99740 7084-24-4 C21H21O11 = 449.38 20mg QQ客服:3257982914
    氯化矢车菊素-3-O-(6''-丙二酰葡糖苷); Cyanidin-3-O-(6''-malonylglucoside) chloride CFN91864 171828-62-9 C24H23ClO14 = 570.9 5mg QQ客服:3257982914
    氯化失车菊素-3,5-O-双葡萄糖苷; Cyanidin-3,5-O-diglucoside chloride CFN92138 2611-67-8 C27H31O16Cl = 647.0 10mg QQ客服:2056216494
    氯化失车菊素-3-O-桑布双糖苷; Cyanidin-3-O-sambubioside chloride CFN92173 33012-73-6 C26H29ClO15 = 617.0 10mg QQ客服:2159513211
    矢车菊素-3-O-半乳糖酸木糖甙氯化物; Cyanidin-3-O-lathyroside chloride CFN91866 31073-32-2 C26H29ClO15 = 617.0 5mg QQ客服:215959384
    氯化矢车菊素-3-O-槐糖苷; Cyanidin 3-sophoroside chloride CFN90469 18376-31-3 C27H31O16.Cl = 646.99 5mg QQ客服:3257982914
    氯化失车菊素-3-O-芸香糖苷; Cyanidin-3-O-rutinoside chloride CFN92135 18719-76-1 C27H31O15Cl = 630.98 10mg QQ客服:2159513211

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