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    黄独素D

    Diosbulbin D

    黄独素D
    产品编号 CFN97140
    CAS编号 66756-57-8
    分子式 = 分子量 C19H20O6 = 344.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Diterpenoids
    植物来源 The roots of Dioscorea bulbifera
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    黄独素D CFN97140 66756-57-8 1mg QQ客服:1413575084
    黄独素D CFN97140 66756-57-8 5mg QQ客服:1413575084
    黄独素D CFN97140 66756-57-8 10mg QQ客服:1413575084
    黄独素D CFN97140 66756-57-8 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
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    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
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    doi: 10.1021/acsnano.7b08969.
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    Nature Plants. 2016 Dec 22;3: 16206.
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  • Molecules. 2013, 18(7):7376-88
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  • ...
  • 生物活性
    Description: Diosbulbin D shows direct toxic effect on hepatocytes, the mechanism could be associated with oxidative stress.
    Targets: ROS
    In vitro:
    Chinese Journal of Natural Medicines, 2011, 9(4):280-5.
    Toxicity of a Diterpene Lactone Isolated from Dioscorea bulbifera on Hepatocytes[Reference: WebLink]
    To test the toxic effects of a diterpene lactone, diosbulbin-D, isolated from Dioscorea bulbifera L. on hepatocytes.
    METHODS AND RESULTS:
    Using the MTT assay to test the effect of Diosbulbin D on hepatocytes.Selected intracellular enzymes release levels by diosbulbin-D were determined to further validate the toxic effect on hepatocytes.Furthermore,the level of intracellular glutathione and the induction of reactive oxygen species(ROS) by diosbulbin-D were measured by fluorometric and flow cytometry methods. Diosbulbin-D showed toxic effect on hepatocytes and a significant increase in intracellular release levels of LDH and the liver enzymes,alanine aminotransferase and aspartate aminotransferase confirmed diosbulbin-D's toxic effect.ROS increase was related to the decrease in level of GSH.Cell pretreated NAC almost completely blocked the ROS fluorescence and recovered the cell growth inhibition induced by diosbulbin-D.
    CONCLUSIONS:
    Diosbulbin-D shows direct toxic effect on hepatocytes.The mechanism could be associated with oxidative stress.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.9036 mL 14.518 mL 29.036 mL 58.072 mL 72.59 mL
    5 mM 0.5807 mL 2.9036 mL 5.8072 mL 11.6144 mL 14.518 mL
    10 mM 0.2904 mL 1.4518 mL 2.9036 mL 5.8072 mL 7.259 mL
    50 mM 0.0581 mL 0.2904 mL 0.5807 mL 1.1614 mL 1.4518 mL
    100 mM 0.029 mL 0.1452 mL 0.2904 mL 0.5807 mL 0.7259 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Borapetoside F; Borapetoside F CFN96279 151200-50-9 C27H34O11 = 534.6 5mg QQ客服:2159513211
    Borapetoside E; Borapetoside E CFN96274 151200-49-6 C27H36O11 = 536.6 5mg QQ客服:3257982914
    Borapetoside D; Borapetoside D CFN96317 151200-48-5 C33H46O16 = 698.7 5mg QQ客服:2159513211
    黄独素C; Diosbulbin C CFN98015 20086-07-1 C19H22O7 = 362.4 5mg QQ客服:2932563308
    黄独素B; 黄独乙素; 黄药子素B; Diosbulbin B CFN98014 20086-06-0 C19H20O6 = 344.4 20mg QQ客服:1413575084
    Methyl-Dodovisate A; Methyl-Dodovisate A CFN97837 1246937-33-6 C21H26O3 = 326.43 5mg QQ客服:2056216494
    Isosalvipuberulin; Isosalvipuberulin CFN99251 115321-32-9 C20H14O5 = 334.3 5mg QQ客服:2056216494
    Tilifodiolide; Tilifodiolide CFN99378 126724-95-6 C20H16O5 = 336.3 5mg QQ客服:2159513211
    Dodonolide; Dodonolide CFN97753 349534-73-2 C20H24O3 = 312.41 5mg QQ客服:2159513211
    黄独素D; Diosbulbin D CFN97140 66756-57-8 C19H20O6 = 344.4 5mg QQ客服:1457312923

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