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  • 二氢藜芦醇

    Dihydroresveratrol

    二氢藜芦醇
    产品编号 CFN98987
    CAS编号 58436-28-5
    分子式 = 分子量 C14H14O3 = 230.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenols
    植物来源 The roots of Dioscorea bulbifera
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    二氢藜芦醇 CFN98987 58436-28-5 10mg QQ客服:2159513211
    二氢藜芦醇 CFN98987 58436-28-5 20mg QQ客服:2159513211
    二氢藜芦醇 CFN98987 58436-28-5 50mg QQ客服:2159513211
    二氢藜芦醇 CFN98987 58436-28-5 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universit?t Basel (Switzerland)
  • University of Limpopo (South Africa)
  • University of Wuerzburg (Germany)
  • China Medical University (Taiwan)
  • University of Medicine and Pharmacy (Romania)
  • Korea Food Research Institute(KFRI) (Korea)
  • Copenhagen University (Denmark)
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  • Tokyo Woman's Christian University (Japan)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Journal of Chromatography A2020, 460942
  • Int Immunopharmacol.2020, 90:107268.
  • J of the Korean Society of Food Science and Nutrition2016, 45(7):1017-1025
  • Front Microbiol.2022, 12:833233.
  • Green Chemistry2021, ISSUE 2.
  • Turkish Journal of Pharmaceutical Sciences2022, DOI: 10.4274
  • Asian Pac J Cancer Prev. 2020, 21(4):935-941.
  • Front Pharmacol.2018, 9:756
  • Biosci Rep.2018, 38(4)
  • University of Limpopo2016, 1777
  • J Sep Sci.2018, 41(9):1938-1946
  • J Holistic Integrative Pharm.2023, 4(1):14-28
  • Acta Edulis Fungi2020, 27(02):63-76.
  • Plants (Basel).2023, 12(22):3877.
  • Int Immunopharmacol.2019, 71:22-31
  • Aquaculture2017, 481:94-102
  • Cosmetics2021, 8(3),91.
  • J Nat Prod.2022, 85(5):1351-1362.
  • Chem Res Toxicol. 2022, acs.chemrestox.2c00049.
  • Horticulturae2022, 8(10), 975.
  • Journal of Analytical Chemistry2017, 854-861
  • Biomed Pharmacother.2023, 163:114785.
  • Molecules.2021, 26(19):6032.
  • ...
  • 生物活性
    Description: Dihydroresveratrol has antiproliferative activity against human prostate cancer PC3 cell line in vitro, it can ameliorate acute pancreatitis-associated lung injury via an inhibitory modulation of pro-inflammatory response, which is associated with a suppression of the NF-κB signaling pathway.
    Targets: p38MAPK | PI3K | NADPH-oxidase | NF-kB | Serine kinase | Threonin kinase
    In vitro:
    Age (Dordr). 2011 Dec;33(4):555-64.
    Resveratrol, but not dihydroresveratrol, induces premature senescence in primary human fibroblasts.[Pubmed: 21318333]
    Resveratrol, trans-3,5,4'-trihydroxystilbene, is a polyphenolic compound which has been reported to mimic the gene expression patterns seen in whole animals undergoing dietary restriction. The mechanism of action of resveratrol remains poorly understood, but modulation of both cellular proliferation and apoptosis has been proposed as important routes by which the molecule may exert its effects. This study reports the effects of both resveratrol and dihydroresveratrol (a primary in vivo metabolite) on the proliferative capacity of human primary fibroblasts.
    METHODS AND RESULTS:
    No generalised reduction in the growth fraction was observed when fibroblasts derived from three different tissues were treated with resveratrol at concentrations of 10 μm or less. However, concentrations above 25 μm produced a dose-dependent reduction in proliferation. This loss of the growth fraction was paralleled by an increase in the senescent fraction as determined by staining for senescence associated beta galactosidase and dose recovery studies conducted over a 7-day period. Entry into senescence in response to treatment with resveratrol could be blocked by a 30-min preincubation with the p38 MAP kinase inhibitor SB203580. No effects on proliferation were observed when cells were treated with dihydroresveratrol at concentrations of up to 100 μm.
    In vivo:
    Sci Rep. 2016 Mar 14;6:22859.
    Inhibition of pancreatic oxidative damage by stilbene derivative dihydro-resveratrol: implication for treatment of acute pancreatitis.[Pubmed: 26971398]
    Trans-resveratrol is a natural stilbenoid possessing multifarious pharmacological benefits; however, when orally consumed, it is rapidly metabolised by colonic microflora and converted to dihydroresveratrol. Thus, this microbial metabolite is of great therapeutic relevance.
    METHODS AND RESULTS:
    In the present study, upon the oral administration of dihydroresveratrol (10-50 mg/kg), the severity of acute pancreatitis in the cerulein-treated rats was significantly ameliorated as evidenced by decreased α-amylase activities in the plasma and lessened oedema formation in the pancreatic parenchyma. In addition, the generation of intracellular reactive oxidative products, including malondialdehyde and protein carbonyls, was accordingly reduced, so as the production of pro-inflammatory cytokines. While inhibiting the activities of NADPH oxidase and myeloperoxidase, the depletion of glutathione was considerably restored. Importantly, the attenuation of pancreatic oxidative damage by dihydroresveratrol was associated with a down-regulation of the nuclear factor-kappaB and phosphatidylinositol 3'-kinase-serine/threonine kinase signalling pathways. Furthermore, we demonstrated that the solubility of dihydroresveratrol was at least 5 times higher than trans-resveratrol whilst exhibiting a much lower cytotoxicity.
    CONCLUSIONS:
    Collectively, the current findings accentuate new mechanistic insight of dihydroresveratrol in pancreatic oxidative damage, and advocate its therapeutic potential for the management of acute pancreatitis, particularly for patients unresponsive to trans-resveratrol due to the lack of proper microbial strains.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.3422 mL 21.7108 mL 43.4216 mL 86.8432 mL 108.5541 mL
    5 mM 0.8684 mL 4.3422 mL 8.6843 mL 17.3686 mL 21.7108 mL
    10 mM 0.4342 mL 2.1711 mL 4.3422 mL 8.6843 mL 10.8554 mL
    50 mM 0.0868 mL 0.4342 mL 0.8684 mL 1.7369 mL 2.1711 mL
    100 mM 0.0434 mL 0.2171 mL 0.4342 mL 0.8684 mL 1.0855 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    去氧土大黄苷元; Desoxyrhapontigenin CFN90854 33626-08-3 C15H14O3 = 242.3 20mg QQ客服:2056216494
    去氧土大黄苷; Desoxyrhaponticin CFN90911 30197-14-9 C21H24O8 = 404.4 20mg QQ客服:1457312923
    土大黄苷 6''-O-没食子酸酯; Rhaponticin 6''-O-gallate CFN91099 94356-23-7 C28H28O13 = 572.51 5mg QQ客服:2056216494
    土大黄苷 2''-O-没食子酸酯; Rhaponticin 2''-O-gallate CFN91100 94356-24-8 C28H28O13 = 572.51 5mg QQ客服:2056216494
    2,3,5,4-四羟基二苯乙烯葡萄糖苷; 2,3,5,4'-Tetrahydroxyl diphenylethylene-2-O-glucoside CFN99995 82373-94-2 C20H22O9 = 406.39 20mg QQ客服:2159513211
    松茋; Pinostilbene CFN98662 42438-89-1 C15H14O3 = 242.3 5mg QQ客服:2159513211
    1-(3',5'-dimethoxy)phenyl-2-[4''-O-beta-D-glucopyranosyl (6→1)-O-α-L-rhamnopyranosyl]phenylethane; 1-(3',5'-dimethoxy)phenyl-2-[4''-O-beta-D-glucopyranosyl (6->1)-O-alpha-L-rhamnopyranosyl]phenylethane CFN95285 1338076-61-1 C28H38O12 = 566.6 5mg QQ客服:2159513211
    Pinostilbenoside; Pinostilbenoside CFN98995 58762-96-2 C21H24O8 = 404.4 5mg QQ客服:2056216494
    3-羟基-5-甲氧基二苯乙烯; 5-Methoxy-3-stilbenol CFN92587 5150-38-9 C15H14O2 = 226.3 5mg QQ客服:2159513211
    Thunalbene; Thunalbene CFN92783 220862-05-5 C15H14O3 = 242.3 5mg QQ客服:1413575084

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