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  • 去氧苦地胆苦素

    Deoxyelephantopin

    去氧苦地胆苦素
    产品编号 CFN97764
    CAS编号 29307-03-7
    分子式 = 分子量 C19H20O6 = 344.36
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Sesquiterpenoids
    植物来源 The herbs of Elephantopus scaber Linn.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    去氧苦地胆苦素 CFN97764 29307-03-7 1mg QQ客服:1413575084
    去氧苦地胆苦素 CFN97764 29307-03-7 5mg QQ客服:1413575084
    去氧苦地胆苦素 CFN97764 29307-03-7 10mg QQ客服:1413575084
    去氧苦地胆苦素 CFN97764 29307-03-7 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Regional Crop Research Institute (Korea)
  • University of Wisconsin-Madison (USA)
  • University of Toulouse (France)
  • Ain Shams University (Egypt)
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • MTT Agrifood Research Finland (Finland)
  • Universidad Industrial de Santander (Colombia)
  • Imperial College London (United Kingdom)
  • Amity University (India)
  • Cancer Research Initatives Foundation(CARIF) (Malaysia)
  • Universidade Federal de Santa Catarina (Brazil)
  • University of Pretoria (South Africa)
  • Korea Intitute of Science and Technology (KIST) (Korea)
  • The Ohio State University (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int J Mol Sci.2022, 23(24):16000.
  • J Pharm Biomed Anal.2019, 172:268-277
  • Ann Transl Med.2019, 7(23):731
  • Exp Parasitol.2015, 153:160-4
  • Braz J Med Biol Res.2021, 54(12):e11183.
  • Nutrients.2020, 12(12):3607.
  • Journal of Life Science2018, 917-922
  • Biochem Biophys Res Commun.2018, 505(1):194-200
  • Molecules.2021, 26(2):E255.
  • Int J Mol Sci. 2014, 15(5):8443-57
  • Front Microbiol.2021, 12:736780.
  • J Ethnopharmacol.2020, 249:112396
  • Front Pharmacol.2023, 14:1095083.
  • Eur J Pharmacol.2018, 832:96-103
  • Korean Journal of Pharmacognosy.2019, 50(1):65-71
  • J Biol Chem.2021, 297(6):101362.
  • Metabolites.2020, 11(1):E11.
  • J Ethnopharmacol.2017, 198:91-97
  • Phytomedicine.2019, 57:95-104
  • Tissue Cell.2022, 78:101901.
  • Food Chem.2019, 290:286-294
  • Cancers (Basel).2023, 15(1):37.
  • J.of Traditional&Complementary Med.2022, 10.1016:j.jtcme.
  • ...
  • 生物活性
    Description: Deoxyelephantopin has anti-inflammatory, hepatoprotective, and wound healing activities; it also has antitumor activity, by inhibiting metastatic, inducing apoptosis, modulating oxidative stress , STAT3/p53/p21 signaling, MAPK pathway, PI3k/Akt/mTOR pathway, caspase cascades, and ROS .
    Targets: ROS | Bcl-2/Bax | Caspase | p53 | p21 | PI3K | mTOR | Akt | STAT | p38MAPK | JNK | ERK | ROS | P450 (e.g. CYP17) | MMP(e.g.TIMP) | NF-kB | EGFR
    In vitro:
    Food Chem Toxicol. 2013 Oct;60:98-108.
    Evaluation of in vitro cytochrome P450 induction and inhibition activity of deoxyelephantopin, a sesquiterpene lactone from Elephantopus scaber L.[Pubmed: 23876819 ]
    Drug metabolism involving cytochrome P450 (CYP) enzymes is a key determinant of significant drug interactions.
    METHODS AND RESULTS:
    Deoxyelephantopin was evaluated for its effects on the expression of mRNAs encoding CYP1A2, CYP2D6 and CYP3A4, and protein expression and resultant enzymatic activity. The mRNA and protein expression of cytochrome isoforms were carried out using an optimized multiplex qRT-PCR assay and Western blot analysis, respectively. Human CYP3A4 protein expression was determined using an optimized hCYP3A4-HepG2 cell-based assay and the enzymatic activity was evaluated using P450-Glo™ CYP3A4 assay. The molecular interaction and possible inhibition of Deoxyelephantopin of the CYP3A4 enzyme was determined in silico and further validated using substrate-specific CYP3A4 inhibition assays. Deoxyelephantopin produced no significant effect on the CYP1A2 and CYP2D6 mRNA and protein expression. However, it has a weak induction effect on CYP3A4 at the transcriptional level.
    CONCLUSIONS:
    In silico docking simulation showed that Deoxyelephantopin has a weak interaction with CYP3A4 enzyme and it minimally affects the metabolism of CYP3A4 substrates. Deoxyelephantopin is not an in vitro CYP1A2 and CYP2D6 inducer. It is both a weak in vitro CYP3A4 inducer and inhibitor and is unlikely to elicit a clinically significant effect in human.
    Nat Prod Res. 2015 Feb 17:1-5.
    Anti-metastatic effect of deoxyelephantopin from Elephantopus scaber in A549 lung cancer cells in vitro.[Pubmed: 25686703]

    METHODS AND RESULTS:
    In this study, we focused on the in vitro anti-metastatic effects of deoxyelephantopin (DOE), a sesquiterpene lactone from Elephantopus scaber on lung cancer A549 cells. DOE significantly decreased the metastatic potential of A549 cells as demonstrated by transwell invasion and migration assay. DOE inhibited the expression of matrix metalloproteinase-2 (MMP-2), MMP-9, urokinase-type plasminogen activator and urokinase-type plasminogen activator receptor at transcript level. Tissue inhibitors of metalloproteinase-2 (TIMP-2) mRNA levels was up-regulated in A549 tumour cells without any change in TIMP-1 expression after DOE treatment. DOE inhibited the protein levels of p-ERK1/2 and p-Akt in A549 cells but it activated p-JNK, p-p38 protein expression. NF-κB and IκBα expressions were down-regulated in DOE-treated cells.
    CONCLUSIONS:
    All these results demonstrated that DOE has shown anti-metastatic activity against A549 tumour cells.
    In vivo:
    Indian J. Pharmacol., 2005, 37(4):238-42.
    Wound healing activity of the leaf extracts and deoxyelephantopin isolated from Elephantopus scaber Linn.[Reference: WebLink]
    To evaluate the wound healing activity of the leaf extracts and Deoxyelephantopin isolated from Elephantopus scaber Linn.
    METHODS AND RESULTS:
    The effect of aqueous ethanol extracts and the isolated compound Deoxyelephantopin from E. scaber Linn. (Asteraceae) was evaluated on excision, incision, and dead space wound models in rats. The wound-healing activity was assessed by the rate of wound contraction, period of epithelialization, skin-breaking strength, weight of the granulation tissue, and collagen content. Histological study of the granulation tissue was carried out to know the extent of collagen formation in the wound tissue. The ethanol extract and the isolated constituent Deoxyelephantopin of E. scaber promoted wound-healing activity in all the three wound models. Significant ( P <0.01) increase in the rate of wound contraction on day 16 (98.8%, P <0.01), skin-breaking strength (412 g, P <0.01), and weight of the granulation tissue on day 10 (74 mg/100 g, P <0.01) were observed with Deoxyelephantopin-treated animals. In ethanol extract-treated animals, the rate of wound contraction on day 16, skin-breaking strength, and weight of the granulation tissue on day 10 ( P <0.01) were 92.4%, 380 g, and 61.67 mg/100 g, respectively. Histological studies of the granulation tissue also evidenced the healing process by the presence of a lesser number of chronic inflammatory cells, lesser edema, and increased collagenation than the control.
    CONCLUSIONS:
    The wound-healing activity was more significant in Deoxyelephantopin-treated animals.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.9039 mL 14.5197 mL 29.0394 mL 58.0788 mL 72.5984 mL
    5 mM 0.5808 mL 2.9039 mL 5.8079 mL 11.6158 mL 14.5197 mL
    10 mM 0.2904 mL 1.452 mL 2.9039 mL 5.8079 mL 7.2598 mL
    50 mM 0.0581 mL 0.2904 mL 0.5808 mL 1.1616 mL 1.452 mL
    100 mM 0.029 mL 0.1452 mL 0.2904 mL 0.5808 mL 0.726 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    表美国鹅掌楸内酯; Epitulipinolide CFN98252 24164-13-4 C17H22O4 = 290.4 5mg QQ客服:215959384
    小白菊内酯; Parthenolide CFN98034 20554-84-1 C15H20O3 = 248.3 20mg QQ客服:1457312923
    鹅掌揪内酯; Lipiferolide CFN98642 41059-80-7 C17H22O5 = 306.4 5mg QQ客服:215959384
    环氧表美国鹅掌楸内酯; Epitulipinolide diepoxide CFN98630 39815-40-2 C17H22O6 = 322.4 5mg QQ客服:2159513211
    Heliangin; Heliangin CFN96222 13323-48-3 C20H26O6 = 362.4 5mg QQ客服:2159513211
    8beta-(4-Hydroxytigloyloxy)ovatifolin; 8beta-(4-Hydroxytigloyloxy)ovatifolin CFN96820 554449-27-3 C22H28O7 = 404.45 5mg QQ客服:2056216494
    Demethylsonchifolin; Demethylsonchifolin CFN97591 956384-55-7 C20H24O6 = 360.41 5mg QQ客服:1413575084
    Uvedalin; Uvedalin CFN97776 24694-79-9 C23H28O9 = 448.47 5mg QQ客服:215959384
    沼菊素氯海德林; Enhydrin chlorohydrin CFN97746 38230-99-8 C23H29ClO10 = 500.93 5mg QQ客服:2056216494
    Chlorouvedalin; Chlorouvedalin CFN97775 24694-80-2 C23H29ClO9 = 484.93 5mg QQ客服:215959384

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