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  • 去氢二松柏醇

    Dehydrodiconiferyl alcohol

    去氢二松柏醇
    产品编号 CFN96567
    CAS编号 4263-87-0
    分子式 = 分子量 C20H22O6 = 358.39
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Lignans
    植物来源 The stems of Cucurbita moschata.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
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    去氢二松柏醇 CFN96567 4263-87-0 1mg QQ客服:1413575084
    去氢二松柏醇 CFN96567 4263-87-0 5mg QQ客服:1413575084
    去氢二松柏醇 CFN96567 4263-87-0 10mg QQ客服:1413575084
    去氢二松柏醇 CFN96567 4263-87-0 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Ethnopharmacol.2022, 291:115159.
  • J Korean Med Obes Res.2023, 23:10-7
  • Front Neurosci.2019, 13:1091
  • Nat Commun.2021, 12(1):681.
  • J Ethnopharmacol.2017, 196:75-83
  • Nutr Res Pract.2020, 14(3):203-217.
  • FEBS Lett.2015, 589(1):182-7
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  • Cytotechnology.2017, 69(5):765-773
  • Anal Chim Acta.2021, 1180:338874.
  • Anal Bioanal Chem.2023, 415(9):1641-1655.
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  • ...
  • 生物活性
    Description: Dehydrodiconiferyl alcohol shows anti-adipogenic and anti-lipogenic effects in 3T3-L1 cells and primary mouse embryonic fibroblasts. Dehydrodiconiferyl alcohol can modulate the differentiation of Th17 and Th1 cells and suppress experimental autoimmune encephalomyelitis, it may be a potential candidate as an agent for the control of Th17 and Th1-mediated inflammatory diseases. (+)-(2S,3R)-Dehydrodiconiferyl alcohol is an antioxidant, it has an inhibitory effect on VCAM-1 expression via JNK pathway in endothelial cells and therefore may serve as a novel pharmacological agent to improve endothelial dysfunction.
    Targets: CDK | DNA/RNA Synthesis | IL Receptor | NF-kB | IFN-γ | JNK
    In vitro:
    Journal of Biological Chemistry, 2012, 287(12):8839-51.
    Dehydrodiconiferyl Alcohol Isolated from Cucurbita moschata Shows Anti-adipogenic and Anti-lipogenic Effects in 3T3-L1 Cells and Primary Mouse Embryonic Fibroblasts*[Reference: WebLink]
    A water-soluble extract from the stems of Cucurbita moschata, code named PG105, was previously found to contain strong anti-obesity activities in a high fat diet-induced obesity mouse model. One of its biological characteristics is that it inhibits 3T3-L1 adipocyte differentiation.
    METHODS AND RESULTS:
    To isolate the biologically active compound(s), conventional solvent fractionation was performed, and the various fractions were tested for anti-adipogenic activity using Oil Red O staining method. A single spot on thin layer chromatography of the chloroform fraction showed a potent anti-adipogenic activity. When purified, the structure of its major component was resolved as dehydrodiconiferyl alcohol (DHCA), a lignan, by NMR and mass spectrometry analysis. In 3T3-L1 cells, synthesized DHCA significantly reduced the expression of several adipocyte marker genes, including peroxisome proliferator-activated receptor γ (Pparg), CCAAT/enhancer-binding protein α (Cebpa), fatty acid-binding protein 4 (Fabp4), sterol response element-binding protein-1c (Srebp1c), and stearoyl-coenzyme A desaturase-1 (Scd), and decreased lipid accumulation without affecting cell viability. DHCA also suppressed the mitotic clonal expansion of preadipocytes (an early event of adipogenesis), probably by suppressing the DNA binding activity of C/EBPβ, and lowered the production level of cyclinA and cyclin-dependent kinase 2 (Cdk2), coinciding with the decrease in DNA synthesis and cell division. In addition, DHCA directly inhibited the expression of SREBP-1c and SCD-1. Similar observations were made, using primary mouse embryonic fibroblasts.
    CONCLUSIONS:
    Taken together, our data indicate that DHCA may contain dual activities, affecting both adipogenesis and lipogenesis.
    In vivo:
    Mol Immunol. 2015 Dec;68(2 Pt B):434-44.
    Dehydrodiconiferyl alcohol (DHCA) modulates the differentiation of Th17 and Th1 cells and suppresses experimental autoimmune encephalomyelitis.[Pubmed: 26477735]
    Dehydrodiconiferyl alcohol (DHCA), originally isolated from the stems of Cucurbita moschata, has previously been shown to exhibit anti-adipogenic and anti-lipogenic effects in 3T3-L1 cells and primary mouse embryonic fibroblasts (MEFs) (Lee et al., 2012).
    METHODS AND RESULTS:
    Here, we investigated whether synthetic DHCA could suppress the CD4 T helper 17 (Th17)-mediated production of the interleukin (IL)-17 protein. The results from RT-qPCR suggest that DHCA-mediated down-regulation of IL-17 occurred at the transcriptional level by suppressing the expression of RAR-related orphan receptor (ROR)γt, the master transcription factor involved in the differentiation of Th17 cells. Furthermore, such inhibition was mediated by the suppression of NF-κB activity. DHCA also inhibited the Th1-mediated production of interferon (IFN) γ by controlling the expression of a key transcription factor known to regulate the production of this cytokine, T-bet. In the mouse experimental autoimmune encephalomyelitis (EAE) model, DHCA showed significant therapeutic effects by inhibiting the infiltration of immune cells into the spinal cords, decreasing the differentiation of pathogenic Th17 and Th1 cells, suppressing the expression of various pro-inflammatory cytokines, and eventually ameliorating the clinical symptoms of EAE mice.
    CONCLUSIONS:
    Taken together, our data indicate that DHCA may be a potential candidate as an agent for the control of Th17 and Th1-mediated inflammatory diseases.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.7903 mL 13.9513 mL 27.9026 mL 55.8051 mL 69.7564 mL
    5 mM 0.5581 mL 2.7903 mL 5.5805 mL 11.161 mL 13.9513 mL
    10 mM 0.279 mL 1.3951 mL 2.7903 mL 5.5805 mL 6.9756 mL
    50 mM 0.0558 mL 0.279 mL 0.5581 mL 1.1161 mL 1.3951 mL
    100 mM 0.0279 mL 0.1395 mL 0.279 mL 0.5581 mL 0.6976 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    (3beta,4alpha)-3-羟基-24-亚甲基-9,19-环羊毛甾烷-28-酸; 1-Dehydroxy-23-deoxojessic acid CFN99619 149252-87-9 C31H50O3 = 470.7 5mg QQ客服:3257982914
    Drahebenine ; Drahebenine CFN96739 1399049-43-4 C13H16N2O2 = 232.28 5mg QQ客服:2056216494
    1,5,7'-联大黄素甲醚; Floribundone 1 CFN97845 118555-84-3 C32H22O10 = 566.52 5mg QQ客服:2159513211
    Ustusol C; Ustusol C CFN96463 1188398-13-1 C16H28O4 = 284.39 5mg QQ客服:1457312923

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