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  • 去氢苦木碱

    Dehydrocrenatidine

    去氢苦木碱
    产品编号 CFN97116
    CAS编号 65236-62-6
    分子式 = 分子量 C15H14N2O2 = 254.3
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Alkaloids
    植物来源 The barks of Picrasma quassioides
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    去氢苦木碱 CFN97116 65236-62-6 1mg QQ客服:2056216494
    去氢苦木碱 CFN97116 65236-62-6 5mg QQ客服:2056216494
    去氢苦木碱 CFN97116 65236-62-6 10mg QQ客服:2056216494
    去氢苦木碱 CFN97116 65236-62-6 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Pak J Pharm Sci.2023, 36(1):51-57.
  • Int J Mol Sci.2019, 20(16):E4015
  • Antioxidants (Basel).2021, 10(1):112.
  • Plant Methods.2017, 13:108
  • Front Pharmacol.2022, 13:906763.
  • Acta Pharm Sin B.2015, 5(4):323-9.
  • Anal Bioanal Chem.2018, 410(5):1561-1569
  • Journal of Ginseng Research2019, 10.1016
  • Front Microbiol.2022, 13:835463.
  • Int J Mol Sci.2022, 23(21):12816.
  • Korean Journal of Pharmacognosy2018, 49(1):76-83
  • Natural Product Communications2020, doi: 10.1177.
  • J Traditional Thai Medical Res.2022, 8(1):pp1-14.
  • Applied Biological Chemistry2023, 66:42.
  • Polytechnic University of Catalonia2017, 105826
  • Molecules.2020, 25(11):2599.
  • Srinagarind Medical Journal2019, 34(1)
  • Cancers (Basel).2023, 15(1):293.
  • Mol Divers.2022, s11030-022-10586-3.
  • Journal of Physiology & Pathology in Korean Medicine.2018, 32(2): 106-112
  • Toxins (Basel).2020, 12(4):210.
  • Front Pharmacol.2021, 12:635510.
  • Evid Based Complement Alternat Med.2017, 2017:6360836
  • ...
  • 生物活性
    Description: Dehydrocrenatidine is a JAK-specific inhibitor, can inhibit JAK-STAT3-dependent DU145 and MDA-MB-468 cell survival and induce cell apoptosis.
    Targets: JAK | STAT | IL Receptor
    In vitro:
    Mol Pharmacol. 2015 Apr;87(4):572-81.
    Dehydrocrenatidine is a novel janus kinase inhibitor.[Pubmed: 25583084]
    Janus kinase (JAK) 2 plays a pivotal role in the tumorigenesis of signal transducers and activators of transcription (STAT) 3 constitutively activated solid tumors. JAK2 mutations are involved in the pathogenesis of various types of hematopoietic disorders, such as myeloproliferative disorders, polycythemia vera, essential thrombocythemia, and primary myelofibrosis. Thus, small-molecular inhibitors targeting JAK2 are potent for therapy of these diseases.
    METHODS AND RESULTS:
    In this study, we screened 1,062,608 drug-like molecules from the ZINC database and 2080 natural product chemicals. We identified a novel JAK family kinase inhibitor, Dehydrocrenatidine, that inhibits JAK-STAT3-dependent DU145 and MDA-MB-468 cell survival and induces cell apoptosis. Dehydrocrenatidine represses constitutively activated JAK2 and STAT3, as well as interleukin-6-, interferon-α-, and interferon-γ-stimulated JAK activity, and STAT phosphorylation, and suppresses STAT3 and STAT1 downstream gene expression. Dehydrocrenatidine inhibits JAKs-JH1 domain overexpression-induced STAT3 and STAT1 phosphorylation. In addition, Dehydrocrenatidine inhibits JAK2-JH1 kinase activity in vitro. Importantly, Dehydrocrenatidine does not show significant effect on Src overexpression and epidermal growth factor-induced STAT3 activation.
    CONCLUSIONS:
    Our results indicate that Dehydrocrenatidine is a JAK-specific inhibitor.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.9324 mL 19.6618 mL 39.3236 mL 78.6473 mL 98.3091 mL
    5 mM 0.7865 mL 3.9324 mL 7.8647 mL 15.7295 mL 19.6618 mL
    10 mM 0.3932 mL 1.9662 mL 3.9324 mL 7.8647 mL 9.8309 mL
    50 mM 0.0786 mL 0.3932 mL 0.7865 mL 1.5729 mL 1.9662 mL
    100 mM 0.0393 mL 0.1966 mL 0.3932 mL 0.7865 mL 0.9831 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    苦木西碱I; Picrasidine I CFN99019 100234-59-1 C14H12N2O2 = 240.3 5mg QQ客服:1413575084
    苦木西碱J; Picrasidine J CFN99020 100234-62-6 C14H14N2O2 = 242.3 5mg QQ客服:215959384
    去氢苦木碱; Dehydrocrenatidine CFN97116 65236-62-6 C15H14N2O2 = 254.3 5mg QQ客服:1457312923
    1-乙酰基-beta-咔啉; 1-Acetyl-beta-carboline CFN92122 50892-83-6 C13H10N2O = 210.2 5mg QQ客服:1413575084
    苦木碱B;1-甲氧基羰基-beta-咔啉; 1-Methoxycarbonyl-beta-carboline CFN98456 3464-66-2 C13H10N2O2 = 226.2 5mg QQ客服:3257982914
    苦木碱C; 1-Formyl-beta-carboline CFN91567 20127-63-3 C12H8N2O = 196.2 20mg QQ客服:3257982914
    川芎哚; Perlolyrine CFN95291 29700-20-7 C16H12N2O2 = 264.3 5mg QQ客服:215959384
    1-甲氧基羰基-beta-咔啉-N-z氧化物; 1-Methoxycarbonyl-beta-carboline-N-oxide CFN95023 74690-74-7 C13H10N2O3 = 242.2 5mg QQ客服:215959384
    苦木碱A;1-乙氧基羰基-beta-咔啉; 1-Ethoxycarbonyl-beta-carboline CFN92123 72755-19-2 C14H12N2O2 = 240.3 5mg QQ客服:1457312923
    4-羟基-1-甲氧基羰基-beta-咔啉; 4-Hydroxy-1-methoxycarbonyl-beta-carboline CFN92929 74690-72-5 C13H10N2O3 = 242.23 5mg QQ客服:2056216494

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