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  • 癸二酸

    Decanedioic acid

    癸二酸
    产品编号 CFN99210
    CAS编号 111-20-6
    分子式 = 分子量 C10H18O4 = 202.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Lipids
    植物来源 The herbs of Piper cubeba.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    癸二酸 CFN99210 111-20-6 10mg QQ客服:2159513211
    癸二酸 CFN99210 111-20-6 20mg QQ客服:2159513211
    癸二酸 CFN99210 111-20-6 50mg QQ客服:2159513211
    癸二酸 CFN99210 111-20-6 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Siksha O Anusandhan University (India)
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  • Helmholtz Zentrum München (Germany)
  • University of Wollongong (Australia)
  • University of Vienna (Austria)
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  • Massachusetts General Hospital (USA)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Biofactors.2018, 44(2):168-179
  • Int J Mol Sci.2021, 22(2):770.
  • Biomedicines.2022, 10(5):1170
  • Int J Mol Med.2016, 37(2):501-8
  • Int J Biol Macromol.2021, 199:189-200.
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  • Hum Exp Toxicol.2023, 42:9603271231171642.
  • Pak J Pharm Sci.2019, 32(6):2879-2885
  • Archives of Biological sciences2022, 00:21-21
  • Nutraceuticals2022, 2(3),150-161
  • ACS Synth Biol.2022, 11(10):3296-3304.
  • Molecules.2019, 24(19):E3417
  • J. Soc. Cosmet. Sci. Korea2021, 47(1):57-63
  • Clin Transl Med.2021, 11(5):e392.
  • Korean J. Medicinal Crop Sci2021, 10:345-352.
  • The Malaysian journal of pathology2019, 41(3):243-251
  • J Food Biochem.2019, 43(9):e12970
  • Pharmaceutics.2020, 12(9):882.
  • Front Pharmacol.2021, 12:765521.
  • ACS Pharmacol. Transl. Sci.2023, 3c00129.
  • Nutrients.2023, 15(6):1335.
  • Int J Mol Sci.2021, 22(17):9400.
  • Korean J. Medicinal Crop Sci.2022, 30(2):124-133
  • ...
  • 生物活性
    Description: Decanedioic acid is a saturated, straight-chain naturally occurring dicarboxylic acid, it exhibits significantly higher anti-HIV activity.
    Targets: HIV
    In vitro:
    Tetrahedron Lett. 2014 Mar 19;55(12):1983-1986.
    Synthesis and Biological Evaluation of 5'-O-Dicarboxylic Fatty Acyl Monoester Derivatives of Anti-HIV Nucleoside Reverse Transcriptase Inhibitors.[Pubmed: 24791029]
    A number of 5'-O-dicarboxylic fatty acyl monoester derivatives of 3'-azido-3'-deoxythymidine (zidovudine, AZT), 2',3'-didehydro-2',3'-dideoxythymidine (stavudine, d4T), and 3'-fluoro-3'-deoxythymidine (alovudine, FLT) were synthesized to improve the lipophilicity and potentially the cellular delivery of parent polar 2', 3'-dideoxynucleoside (ddN) analogues.
    METHODS AND RESULTS:
    The compounds were evaluated for their anti-HIV activity. Three different fatty acids with varying chain length of suberic acid (octanedioic acid), sebacic acid (decanedioic acid), and dodecanedioic acid were used for the conjugation with the nucleosides. The compounds were evaluated for anti-HIV activity and cytotoxicity. All dicarboxylic ester conjugates of nucleosides exhibited significantly higher anti-HIV activity than that of the corresponding parent nucleoside analogs.
    CONCLUSIONS:
    Among all the tested conjugates, 5'-O-suberate derivative of AZT (EC50 = 0.10 nM) was found to be the most potent compound and showed 80-fold higher anti-HIV activity than AZT without any significant toxicity (TC50 > 500 nM).
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.9432 mL 24.7158 mL 49.4315 mL 98.8631 mL 123.5788 mL
    5 mM 0.9886 mL 4.9432 mL 9.8863 mL 19.7726 mL 24.7158 mL
    10 mM 0.4943 mL 2.4716 mL 4.9432 mL 9.8863 mL 12.3579 mL
    50 mM 0.0989 mL 0.4943 mL 0.9886 mL 1.9773 mL 2.4716 mL
    100 mM 0.0494 mL 0.2472 mL 0.4943 mL 0.9886 mL 1.2358 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    花生四烯酸; Arachidonic acid CFN90058 506-32-1 C20H32O2 = 304.47 20mg QQ客服:1457312923
    月桂酸; Lauric acid CFN90493 143-07-7 C12H24O2 = 200.31 20mg QQ客服:1457312923
    棕榈酸; 十六酸; 软脂酸; Palmitic acid CFN99716 57-10-3 C16H32O2 = 256.42 20mg QQ客服:2159513211
    二十三碳酸; Tricosanoic acid CFN98571 2433-96-7 C23H46O2 = 354.61 20mg QQ客服:3257982914
    二十八烷酸; Octacosanoic Acid CFN98572 506-48-9 C28H56O2 = 424.74 20mg QQ客服:2056216494
    硬脂酸,十八碳酸,十八酸,十八(烷)酸; Stearic Acid CFN93165 57-11-4 C18H36O2 = 284.5 20mg QQ客服:1457312923
    亚油酸; Linoleic acid CFN93168 60-33-3 C18H32O2 = 280.5 20mg QQ客服:215959384
    油酸; Oleic acid CFN94800 112-80-1 C18H34O2 = 282.5 20mg QQ客服:2056216494
    9,16-二氧代-10,12,14-十八碳三烯酸; 9,16-Dioxo-10,12,14-octadecatrienoic acid CFN98082 217810-46-3 C18H26O4 = 306.4 5mg QQ客服:1457312923
    2-羟基二十四烷酸乙酯; 2-Hydroxytetracosanoic acid ethyl ester CFN99353 124111-47-3 C26H52O3 = 412.7 5mg QQ客服:215959384

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