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  • 丹参素

    Danshensu

    丹参素
    产品编号 CFN99539
    CAS编号 22681-72-7
    分子式 = 分子量 C9H10O5 = 198.17
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenylpropanoids
    植物来源 The roots of Salvia miltiorrhiza Bge.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    丹参素 CFN99539 22681-72-7 10mg QQ客服:215959384
    丹参素 CFN99539 22681-72-7 20mg QQ客服:215959384
    丹参素 CFN99539 22681-72-7 50mg QQ客服:215959384
    丹参素 CFN99539 22681-72-7 100mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Minnesota (USA)
  • Northeast Normal University Changchun (China)
  • Charles Sturt University (Denmark)
  • Weizmann Institute of Science (Israel)
  • The Australian National University (Australia)
  • University of Madras (India)
  • Wroclaw Medical University (Poland)
  • Universitas islam negeri Jakarta (Indonesia)
  • Martin Luther University of Halle-Wittenberg (Germany)
  • Stanford University (USA)
  • Tohoku University (Japan)
  • Agricultural Research Organization (ARO) (Israel)
  • Monash University (Australia)
  • Chiang Mai University (Thailand)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules.2017, 22(2)
  • J of the Korean Society of Cosmetics and Cosmetology2018, 399-406
  • Biomimetics (Basel).2022, 7(4):154.
  • Biochem Pharmacol.2017, 130:10-20
  • LWT2021, 150:112021.
  • Oncol Rep.2019, 41(4):2453-2463
  • Front Microbiol.2023, 14:1232039.
  • American Association for Anatomy2020, doi: 10.1002.
  • Phytother Res.2020, 34(4):788-795.
  • PLoS One.2017, 12(3):e0173585
  • Regul Toxicol Pharmacol.2023, 142:105433.
  • J Pharmaceut Biomed2020, 178:112894
  • Asian J Beauty Cosmetol2022, 20(2):183-191
  • Molecules.2021, 26(16):4722.
  • BMC Complement Altern Med.2014, 14:352
  • Molecules.2023, 28(9):3685.
  • Anal Bioanal Chem.2018, 410(5):1561-1569
  • Vietnam Journal of Food Control.2022, 5(3):pp.488-497.
  • J Appl Biol Chem2023, 66:455−461
  • The Korea Journal of Herbology2016, 29-35
  • Molecular & Cellular Toxicology2022, 10.1007:s13273-022-00277-3
  • Malaysian J of Fundamental and Applied Sciences 2018, 14(3):368-373
  • Process Biochemistry2019, 85:106-115
  • ...
  • 生物活性
    Description: Danshensu has anxiolytic-like, cardioprotective, neuroprotective, and antioxidant activities. It can enhance HO-1 expression to suppress 6-OHDA-induced oxidative damage via PI3K/Akt/Nrf2 signaling pathways and can reduce 6-OHDA-induced dopaminergic neuronal loss in zebrafish. Chronic treatment with danshensu can prevent/attenuate the formation of atherosclerosis.
    Targets: 5-HT Receptor | PI3K | Akt | GSK-3 | Nrf2 | HO-1 | TNF-α | NO
    In vitro:
    Neurosci Lett. 2013 May 24;543:121-5.
    Danshensu protects against 6-hydroxydopamine-induced damage of PC12 cells in vitro and dopaminergic neurons in zebrafish.[Pubmed: 23562886]
    The overproduction of reactive oxygen species (ROS) has been implicated in the development of neurodegenerative diseases such as Parkinson's disease (PD) and Alzheimer's disease (AD). Previous studies have indicated that danshensu (beta-3,4-dihydroxyphenyl-lactic acid), a main hydrophilic component of the Chinese materia medica Radix Salviae Miltiorrhizae (Danshen, Pharmacopoeia of PR China), has ROS scavenging and antioxidant activities, however its mechanism of action was not clear.
    METHODS AND RESULTS:
    In this study, we investigated whether the protective effects of danshensu against neurotoxin 6-hydroxydopamine (6-OHDA)-induced oxidative stress involved the Nrf2/HO-1 pathways. Pretreatment with danshensu in PC12 cells significantly attenuated 6-OHDA-induced cytotoxicity and the production of ROS. Danshensu activated the nuclear translocation of Nrf2 to increase heme oxygenase-1 (HO-1), conferring protection against ROS. Danshensu induced the phosphorylation of Akt, and its cytoprotective effect was abolished by PI3K, Akt and HO-1 inhibitors. These results confirmed the crucial role of PI3K/Akt and HO-1 signaling pathways as the underlying mechanistic action of danshensu.
    CONCLUSIONS:
    Taken together, the results suggest that danshensu enhances HO-1 expression to suppress 6-OHDA-induced oxidative damage via PI3K/Akt/Nrf2 signaling pathways. Moreover, 6-OHDA-induced dopaminergic neuronal loss in zebrafish could be reduced by danshensu, further supporting the neuroprotective potential of danshensu.
    In vivo:
    Life Sci. 2014 Apr 17;101(1-2):73-8.
    Anxiolytic-like effect of danshensu [(3-(3,4-dihydroxyphenyl)-lactic acid)] in mice.[Pubmed: 24582592]
    Danshensu [3-(3,4-dihydroxyphenyl)-lactic acid], a phenylpropanoid compound isolated from Prunella vulgaris var. lilacina, is a well-known antioxidant. Although its antioxidant activity and cardioprotective effect have been reported, the pharmacological properties of danshensu in the central nervous system remain unclear. We investigated whether danshensu exerts anxiolytic-like activity in mice.
    METHODS AND RESULTS:
    We conducted monoamine oxidase A (MAO-A) inhibition assay on danshensu in vitro, and behavioral tests including the elevated plus-maze test (EPM), the hole-board test, the rotarod test and the open field test were employed. We found that danshensu significantly inhibited the activity of MAO-A in vitro. The administration of danshensu (3 or 10mg/kg) produced a significant anxiolytic-like effect in the EPM and hole-board test. In addition, no changes in the spontaneous locomotor activity and no myorelaxant effects were observed compared to the control group; these effects were confirmed with the open field test and the rotarod test. Moreover, the anxiolytic-like properties of danshensu were antagonized by a dopamine D1 receptor antagonist (SCH 23390) but not by a 5-HT1A receptor antagonist (WAY 100635) or an α1-adrenergic receptor antagonist (prazosin).
    CONCLUSIONS:
    These results indicate that danshensu exerts its anxiolytic-like properties, in part, through dopaminergic neurotransmitter signaling.
    Acta Pharmacol Sin. 2010 Oct;31(10):1395-400.
    Danshensu protects vascular endothelia in a rat model of hyperhomocysteinemia.[Pubmed: 20871618 ]
    To examine whether danshensu could protect vascular endothelia in a rat model of hyperhomocysteinemia.
    METHODS AND RESULTS:
    The model was established by feeding rats with a methionine-rich diet (1 g·kg⁻1·d⁻1) for 3 months. Immediately following the discontinuation of methionine-rich diet, rats were treated with danshensu (67.5 mg·kg⁻1·d⁻1, po) or saline for 3 additional months. One group of rats receiving vitamin mixture (folic acid, vitamin B12 and vitamin B6) was included as a positive control. One group of rats not exposed to methionine-rich diet was also included as a blank control. The expression of tumor necrosis factor-alpha (TNF-alpha) and intercellular adhesion molecule-1 (ICAM-1) protein in the descending aorta was examined using immunohistochemistry and Western blot. Homocysteine and blood concentration of endothelin and nitric oxide (NO) was also examined. Methionine-rich diet resulted in accumulation of "foam cells", up-regulated expression of TNF-alpha and ICAM-1 in the descending aorta, and significantly increased serum homocysteine. Plasma endothelin concentration was significantly increased; NO was decreased. Danshensu treatment, either simultaneous to methionine-rich diet or afterwards, attenuated the above mentioned changes.
    CONCLUSIONS:
    Chronic treatment with danshensu could prevent/attenuate the formation of atherosclerosis. Potential mechanisms include inhibited expression of representative proinflammatory cytokines and adhesion molecules in arterial endothelia. Changes in homocysteine and circulating molecules that control vascular contraction/relaxation via endothelial cells (eg, endothelin and NO) were also implicated.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 5.0462 mL 25.2309 mL 50.4617 mL 100.9234 mL 126.1543 mL
    5 mM 1.0092 mL 5.0462 mL 10.0923 mL 20.1847 mL 25.2309 mL
    10 mM 0.5046 mL 2.5231 mL 5.0462 mL 10.0923 mL 12.6154 mL
    50 mM 0.1009 mL 0.5046 mL 1.0092 mL 2.0185 mL 2.5231 mL
    100 mM 0.0505 mL 0.2523 mL 0.5046 mL 1.0092 mL 1.2615 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    异阿魏酸肉桂酯; Cinnamyl isoferulate CFN89441 115610-31-6 C19H18O4 = 310.34 5mg QQ客服:1457312923
    升麻消旋体A; Cimiracemate A CFN95608 478294-16-5 C19H18O7 = 358.4 10mg QQ客服:215959384
    3-(2,4-二羟基苯基)丙酸; 3-(2,4-Dihydroxyphenyl)propionic acid CFN98940 5631-68-5 C9H10O4 = 182.2 20mg QQ客服:1413575084
    3-(2,4-二羟基苯基)丙酸甲酯; Methyl 3-(2,4-dihydroxyphenyl)propionate CFN99823 17422-90-1 C10H12O4 = 196.2 5mg QQ客服:3257982914
    丹参素; Danshensu CFN99539 22681-72-7 C9H10O5 = 198.17 20mg QQ客服:3257982914
    丹参素钠; Sodium Danshensu CFN99163 67920-52-9 C9H9O5Na = 220.2 20mg QQ客服:2159513211
    左旋多巴; Levodopa CFN99800 59-92-7 C9H11NO4 = 197.20 20mg QQ客服:3257982914
    Trans-咖啡酸; Trans-caffeic acid CFN92549 501-16-6 C9H8O4 = 180.2 20mg QQ客服:1413575084
    咖啡酸甲酯; Methyl caffeate acid CFN95561 3843-74-1 C10H10O4 = 194.18 5mg QQ客服:215959384
    咖啡酸乙酯; Ethyl caffeate CFN97136 66648-50-8 C11H12O4 = 208.2 20mg QQ客服:3257982914

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