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  • 丹参醇B

    Danshenol B

    丹参醇B
    产品编号 CFN90474
    CAS编号 189308-09-6
    分子式 = 分子量 C22H26O4 = 354.43
    产品纯度 >=98%
    物理属性 Cryst.
    化合物类型 Diterpenoids
    植物来源 The roots of Salvia miltiorrhiza
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    丹参醇B CFN90474 189308-09-6 1mg QQ客服:1413575084
    丹参醇B CFN90474 189308-09-6 5mg QQ客服:1413575084
    丹参醇B CFN90474 189308-09-6 10mg QQ客服:1413575084
    丹参醇B CFN90474 189308-09-6 20mg QQ客服:1413575084
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
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    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
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  • Phytochemistry2018, 15:83-92
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  • ...
  • 生物活性
    Description: Danshenol B has aldose reductase(AR) inhibitory activity.
    In vitro:
    Chem Pharm Bull (Tokyo). 1997 Aug;45(8):1306-11.
    Aldose reductase inhibitory constituents of the root of Salvia miltiorhiza Bunge.[Pubmed: 9377780]

    METHODS AND RESULTS:
    The constituents of the MeOH extract of Salvia miltiorhiza BUNGE, which showed strong aldose reductase (AR) inhibitory activity, were examined, and two new abietane-type diterpenoids, danshenol A (1) and Danshenol B (2), were isolated together with six known ones: dihydrotanshimme I (3), cryptotanshinone (4), tanshinone I (5), tanshinone IIA (6), (-)-danshexinkun A (7), and sugiol (8). Among them, 4, 5, and 8 were weak AR inhibitors with IC50 from 4.80 to > 10.0 microM, while 1, 2, 3, 6, and 7 were strong inhibitors (IC50 from 0.10 to 1.75 microM).
    CONCLUSIONS:
    Danshenol A (1), the strongest inhibitor, had IC50 of 0.10 microM which is comparable to that of epalrestat in clinical use. Moreover, from a consideration of IC50, and yield of each compound, it was concluded that tanshinone IIA (6) is the major active constituent of the MeOH extract and danshenol A (I) and (-)danshexinkun A(7) are the minor ones.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.8214 mL 14.1072 mL 28.2143 mL 56.4286 mL 70.5358 mL
    5 mM 0.5643 mL 2.8214 mL 5.6429 mL 11.2857 mL 14.1072 mL
    10 mM 0.2821 mL 1.4107 mL 2.8214 mL 5.6429 mL 7.0536 mL
    50 mM 0.0564 mL 0.2821 mL 0.5643 mL 1.1286 mL 1.4107 mL
    100 mM 0.0282 mL 0.1411 mL 0.2821 mL 0.5643 mL 0.7054 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    去氢丹参新酮; Dehydromiltirone CFN98532 116064-77-8 C19H20O2 = 282.38 5mg QQ客服:215959384
    丹参新酮, 次丹参醌; Miltirone CFN98531 27210-57-7 C19H22O2 = 282.38 10mg QQ客服:1413575084
    1,2-二去氢隐丹参酮; 1,2-Didehydrocryptotanshinone CFN92144 891854-92-5 C19H18O3 = 294.4 5mg QQ客服:3257982914
    隐丹参酮; Cryptotanshinone CFN98478 35825-57-1 C19H20O3 = 296.4 20mg QQ客服:2159513211
    Salvianan; Salvianan CFN92637 862832-46-0 C21H23NO2 = 321.4 5mg QQ客服:1457312923
    Neosalvianen; Neosalvianen CFN91827 790673-00-6 C21H21NO2 = 319.4 5mg QQ客服:2159513211
    小红参醌丙; Trijuganone C CFN92780 135247-94-8 C20H20O5 = 340.4 5mg QQ客服:2056216494
    丹参醇B; Danshenol B CFN90474 189308-09-6 C22H26O4 = 354.43 5mg QQ客服:1413575084
    鼠尾草酚酮; Salviolone CFN92163 119400-86-1 C18H20O2 = 268.4 5mg QQ客服:2056216494

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