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  • DL-丁香树脂酚

    DL-Syringaresinol

    DL-丁香树脂酚
    产品编号 CFN99276
    CAS编号 1177-14-6
    分子式 = 分子量 C22H26O8 = 418.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Lignans
    植物来源 The herbs of Liriodendron tulipifera
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    DL-丁香树脂酚 CFN99276 1177-14-6 1mg QQ客服:1457312923
    DL-丁香树脂酚 CFN99276 1177-14-6 5mg QQ客服:1457312923
    DL-丁香树脂酚 CFN99276 1177-14-6 10mg QQ客服:1457312923
    DL-丁香树脂酚 CFN99276 1177-14-6 20mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universit?t Basel (Switzerland)
  • Amity University (India)
  • Max-Planck-Insitut (Germany)
  • University of Mysore (India)
  • Celltrion Chemical Research Institute (Korea)
  • Instytut Nawozów Sztucznych w Pu?awach (Poland)
  • Universidad Industrial de Santander (Colombia)
  • Institute of Chinese Materia Medica (China)
  • Wageningen University (Netherlands)
  • Anna University (India)
  • Mendel University in Brno (Czech Republic)
  • Univerzita Karlova v Praze (Czech Republic)
  • University of Bonn (Germany)
  • VIT University (India)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • BMC Complement Altern Med.2019, 19(1):11
  • Molecules2020, 25(4):892
  • Processes 2021, 9(5),894.
  • Int J Mol Sci.2017, 18(12)
  • Pharmaceuticals (Basel).2021, 14(3):260.
  • Molecules.2019, 24(2):E343
  • J Korean Society of Food Science & Nutrition2021, 50(9): 962-970
  • Chem Biol Interact.2020, 328:109200.
  • Molecules.2021, 26(9):2791.
  • SBRAS2016, 12
  • Molecules.2021, 26(23):7390.
  • South African J of Plant&Soil2018, 29-32
  • JPC-Journal of Planar Chromatography 2017, 30(4)
  • Eur Rev Med Pharmacol Sci.2020, 24(9):5127-5139.
  • J Food Sci Technol.2019, 56(5):2712-2720
  • Chem Biol Interact.2019, 315:108910
  • Theranostics.2023, 13(9):3103-3116.
  • Gene.2022, 815:146178.
  • Antiviral Res.2021, 193:105142.
  • Int J Mol Sci.2022, 23(10):5468.
  • Inflammation2015, 38(1):445-55
  • Am J Chin Med.2016, 44(6):1255-1271
  • American Association for Anatomy2020, doi: 10.1002.
  • ...
  • 生物活性
    Description: (+)-Syringaresinol shows inhibitory activity of Helicobacter pylori motility with the IC50 value is 50 microg/ml. (-)-Syringaresinol has been reported to potently inhibit the proliferation of human promyelocytic HL-60 cells through G 1 arrest and induction of apoptosis, suggests that it may be a potential chemotherapeutic agent for the treatment of cancer. Syringaresinol induces vasorelaxation by enhancing NO production in endothelial cells via two distinct mechanisms, phosphatidylinositol 3-kinase/Akt- and (PLC)/Ca2+/CaMKKβ -dependent eNOS phosphorylation and Ca(2+)-dependent eNOS dimerization. Syringaresinol also can protect against hypoxia/reoxygenation-induced cardiomyocytes injury and death by destabilization of HIF-1α in a FOXO3-dependent mechanism.
    Targets: Antifection | PI3K | Akt | Calcium Channel | NOS | HIF | NO
    In vitro:
    Biol Pharm Bull. 2006 Jan;29(1):172-3.
    Inhibition of Helicobacter pylori motility by (+)-Syringaresinol from unripe Japanese aprico[Pubmed: 16394533]

    METHODS AND RESULTS:
    A methanol extract from unripe Japanese apricot showed inhibitory activity of Helicobacter pylori motility. Inhibitory compound 1 was isolated and identified as (+)-syringaresinol (1) by spectoroscopic means. (+)-Syringaresinol (1) inhibited >90% of the H. pylori motility at a concentration of 500 microg/ml and the IC50 value was 50 microg/ml.
    Int Immunopharmacol. 2008 Jul;8(7):967-73.
    (-)-Syringaresinol inhibits proliferation of human promyelocytic HL-60 leukemia cells via G1 arrest and apoptosis.[Pubmed: 18486907]

    METHODS AND RESULTS:
    The induction of apoptosis after treatment with (-)-syringaresinol for 24 h was demonstrated by morphological changes, DNA fragmentation, altered ratio of Bax/Bcl-2, cleavage of poly(ADP-ribose) polymerase and flow cytometry analysis. (-)-Syringaresinol also induced cytochrome c release and activation of caspase-3 and caspase-9. To our knowledge, this is the first time that (-)-syringaresinol has been reported to potently inhibit the proliferation of human promyelocytic HL-60 cells through G(1) arrest and induction of apoptosis.
    CONCLUSIONS:
    These findings suggest that (-)-syringaresinol may be a potential chemotherapeutic agent for the treatment of cancer.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.3901 mL 11.9503 mL 23.9006 mL 47.8011 mL 59.7514 mL
    5 mM 0.478 mL 2.3901 mL 4.7801 mL 9.5602 mL 11.9503 mL
    10 mM 0.239 mL 1.195 mL 2.3901 mL 4.7801 mL 5.9751 mL
    50 mM 0.0478 mL 0.239 mL 0.478 mL 0.956 mL 1.195 mL
    100 mM 0.0239 mL 0.1195 mL 0.239 mL 0.478 mL 0.5975 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    De-4'-O-methylyangambin; De-4'-O-methylyangambin CFN99618 149250-48-6 C23H28O8 = 432.5 5mg QQ客服:215959384
    鹅掌楸树脂醇 A ; Episyringaresinol CFN96717 51152-20-6 C22H26O8 = 418.44 5mg QQ客服:1457312923
    DL-丁香树脂酚; DL-Syringaresinol CFN99276 1177-14-6 C22H26O8 = 418.4 5mg QQ客服:1457312923
    丁香树脂酚; Syringaresinol CFN92060 487-35-4 C22H26O8 = 418.4 10mg QQ客服:1413575084
    二乙酸丁香树脂醇酯; Syringaresinol diacetate CFN98009 1990-77-8 C26H30O10 = 502.5 5mg QQ客服:215959384
    刺五加甙E1; Acanthoside B CFN97220 7374-79-0 C28H36O13 = 580.6 20mg QQ客服:1413575084
    (-)-丁香树脂醇二葡萄糖甙; 丁香树脂醇双葡萄糖苷; Syringaresinol-di-O-glucoside CFN90458 66791-77-3 C34H46O18 = 742.71 20mg QQ客服:215959384
    鹅掌楸苦素; Liriodendrin CFN98964 573-44-4 C34H46O18 = 742.7 5mg QQ客服:2056216494

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