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  • 仙茅苷

    Curculigoside

    仙茅苷
    产品编号 CFN97419
    CAS编号 85643-19-2
    分子式 = 分子量 C22H26O11 = 466.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenols
    植物来源 The rhizomes of Curculigo orchioides Gaertn.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
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    仙茅苷 CFN97419 85643-19-2 10mg QQ客服:215959384
    仙茅苷 CFN97419 85643-19-2 20mg QQ客服:215959384
    仙茅苷 CFN97419 85643-19-2 50mg QQ客服:215959384
    仙茅苷 CFN97419 85643-19-2 100mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universidad de Antioquia (Colombia)
  • Universidad Veracuzana (Mexico)
  • University of Perugia (Italy)
  • Celltrion Chemical Research Institute (Korea)
  • Michigan State University (USA)
  • University of Bordeaux (France)
  • Leibniz-Institut für Pflanzenbiochemie (IPB) (Germany)
  • Indian Institute of Science (India)
  • Semmelweis Unicersity (Hungary)
  • Siksha O Anusandhan University (India)
  • Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)
  • Wroclaw Medical University (Poland)
  • University of Zurich (Switzerland)
  • Kazusa DNA Research Institute (Japan)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Nat Prod Commun.2014, 9(5):679-82
  • Pharmacogn Mag.2015, 11:S585-91
  • Sci. Rep.2015, 14-23
  • J Pharm Biomed Anal.2016, 129:50-59
  • Acta horticulturae2017, 1158:257-268
  • Sci Rep. 2017, 17332(7)
  • J Ethnopharmacol.2017, 198:205-213
  • Evid Based Complement Alternat Med.2017, 2017:1401279
  • J Ethnopharmacol.2017, 206:73-77
  • Korean J. of Horticultural Sci. & Tech. 2017, 793-804
  • Front Pharmacol.2017, 8:673
  • Microchemical Journal2018, 137:168-173
  • Mol Pharm.2018, 15(8):3285-3296
  • Cell Biochem Funct.2018, 36(6):303-311
  • Biol Pharm Bull.2018, 41(1):65-72
  • J Sep Sci.2018, 41(7):1682-1690
  • Toxicol In Vitro.2018, 52:94-105
  • Molecules.2019, 24(23):E4303
  • Food Chem.2019, 279:80-87
  • Trop J Nat Prod Res.2019, 3(1):6-9
  • Environ Toxicol.2019, 34(12):1354-1362
  • J Agric Food Chem.2019, 67(27):7748-7754
  • Biomolecules.2019, 9(11):E696
  • ...
  • 生物活性
    Description: Curculigoside has potent antioxidant, anti-osteoporotic, immunomodulatory, and neuroprotective effects. Curculigoside can improve cognitive function in aged animals, possibly by decreasing the activity of AchE in the cerebra and inhibiting the expression of BACE1 in the hippocampus. Curculigoside exhibits potent inhibitory activity against matrix metalloproteinase-1 in cultured human skin fibroblasts, and increases the levels of ALP and Runx2 in osteoblasts under oxidative stress via anti-oxidative character.
    Targets: Wnt/β-catenin | NF-kB | BACE | AChR | Caspase | p53 | ROS | NO | NMDAR | Bcl-2/Bax
    In vitro:
    Stem Cells Dev. 2014 Jan 15;23(2):146-54.
    Curculigoside improves osteogenesis of human amniotic fluid-derived stem cells.[Pubmed: 24007307 ]
    Curculigoside, a phenolic glycoside, is the main active compound of Curculigo orchioides (Amaryllidaceae, rhizome). C. orchioides is a traditional Chinese herbal medicine and has been commonly used to treat orthopedic disorders and bone healing in Asia. This study evaluated the effect of curculigoside on osteogenic differentiation of human amniotic fluid-derived stem cells (hAFSCs).
    METHODS AND RESULTS:
    The results showed that curculigoside stimulated alkaline phosphatase activity and calcium deposition of hAFSCs during osteogenic differentiation in a dose-dependent manner (1-100 μg/mL), while the effects were reduced at the higher concentration of 200 μg/mL. From reverse transcriptase-polymerase chain reaction analysis, the osteogenic genes osteopontin (OPN) and Collagen I were upregulated with curculigoside treatment (1-100 μg/mL). Concurrently, the ratio of osteoprotegerin (OPG) to receptor activator of nuclear factor kappa-B ligand (RANKL) was increased, indicating the inhibition of osteoclastogenesis by curculigoside. Moreover, the role of Wnt/β-catenin signaling during curculigoside treatment was revealed by the upregulation of β-catenin and Cyclin D1.
    CONCLUSIONS:
    In summary, curculigoside improved osteogenesis and inhibited osteoclastogenesis of hAFSCs, suggesting its potential use to regulate hAFSC osteogenic differentiation for treating bone disorders.
    J Ethnopharmacol. 2010 Oct 28;132(1):233-9.
    Curculigoside attenuates human umbilical vein endothelial cell injury induced by H2O2.[Pubmed: 20713149]
    Vessel endothelium injury caused by reactive oxygen species (ROS) including H(2)O(2) plays a critical role in the pathogenesis of cardiovascular disorders. Therefore, agents or antioxidants that can inhibit production of ROS has highly clinical values in cardiovascular therapy. Curculigoside is the major bioactive compounds present in Curculigo orchioides, and possess potent antioxidant properties against oxidative stress insults through undefined mechanism(s). The present study was designed to test the hypothesis that curculigoside can inhibit H(2)O(2)-induced injury in human umbilical vein endothelial cells.
    METHODS AND RESULTS:
    Human umbilical vein endothelial cells (HUVECs) were treated with curculigoside in the presence/absence of hydrogen peroxide (H(2)O(2)). The protective effects of curculigoside OP-D against H(2)O(2) were evaluated. HUVECs incubated with 400 μM H(2)O(2) had significantly decreased the viability of endothelial cells, which was accompanied with apparent cells apoptosis, the activation of caspase-3 and the upregulation of p53 mRNA expression. In addition, H(2)O(2) treatment induced a marked increase of MDA, LDH content and in intracellular ROS, decreased the content of nitric oxide (NO) and GSH-Px activities in endothelial cells. However, pretreatment with 0.5.5,10 μM curculigoside resulted in a significant recovery from H(2)O(2)-induced cell apoptosis. Also, it decreased other H(2)O(2)-induced damages in a concentration-dependent manner. Furthermore, pretreatment with curculigoside decreased the activity of caspase-3 and p53 mRNA expression, which was known to play a key role in H(2)O(2)-induced cell apoptosis.
    CONCLUSIONS:
    The present study shows that curculigoside can protect endothelial cells against oxidative injury induced by H(2)O(2), suggesting that this compound may constitute a promising intervention against cardiovascular disorders.
    Arch Pharm Res. 2009 Oct;32(10):1433-9.
    The effect of curculigoside on the expression of matrix metalloproteinase-1 in cultured human skin fibroblasts.[Pubmed: 19898807 ]
    The dried rhizomes of Curculigo orchioides G. yielded two phenolic glycosides, curculigoside (1), orcinol-beta-D-glucoside (4), and two cycloartane saponins, curculigosaponin G (2), curculigosaponin I (3). The structures were determined using spectroscopic methods.
    METHODS AND RESULTS:
    Among these isolates, compound 1 exhibited potent inhibitory activity against matrix metalloproteinase-1 in cultured human skin fibroblasts. In addition, it increased the level of Bcl-2 protein expression and decreased the level of Bax protein expression. Compound 4 was isolated from this plant for the first time.
    In vivo:
    J Pharm Pharmacol. 2013 Jul;65(7):1005-13.
    Curculigoside promotes osteogenic differentiation of bone marrow stromal cells from ovariectomized rats.[Pubmed: 23738728 ]
    Curculigoside, a natural compound isolated from the medicinal plant Curculigo orchioides has been reported to prevent bone loss in ovariectomized rats. However, the underlying molecular mechanisms are largely unknown. This study investigated the effects of curculigoside on proliferation and osteogenic differentiation of bone marrow stromal cells (BMSCs).
    METHODS AND RESULTS:
    The toxicity, proliferation and osteogenic differentiation of BMSCs cultured with various concentrations (0 as control, 10, 100 and 500 μm) of curculigoside were measured by viability assay, MTT analysis, alkaline phosphatase (ALP) activity assay, alizarin red staining and mineralization assay, real-time PCR analysis on osteogenic genes including ALP, type I collagen (Col I), osteocalcin (OCN) and osteoprotegerin (OPG), runt-related transcription factor 2 (Runx2), as well as OPG enzyme-linked immunosorbent assay. No significant cytotoxicity was observed for BMSCs after supplementation with curculigoside. The proliferation of BMSCs was enhanced after administration of curculigoside, especially 100 μm curculigoside. Moreover, the osteogenic gene expression was significantly enhanced with 100 μm curculigoside treatment. Importantly, curculigoside significantly increased OPG secretion.
    CONCLUSIONS:
    The data indicate that curculigoside could promote BMSC proliferation and induce osteogenic differentiation of BMSCs. The most profound response was observed with 100 μm curculigoside. These findings may be valuable for understanding the mechanism of the effect of curculigoside on bone, especially in relation to osteoporosis.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1441 mL 10.7204 mL 21.4408 mL 42.8816 mL 53.6021 mL
    5 mM 0.4288 mL 2.1441 mL 4.2882 mL 8.5763 mL 10.7204 mL
    10 mM 0.2144 mL 1.072 mL 2.1441 mL 4.2882 mL 5.3602 mL
    50 mM 0.0429 mL 0.2144 mL 0.4288 mL 0.8576 mL 1.072 mL
    100 mM 0.0214 mL 0.1072 mL 0.2144 mL 0.4288 mL 0.536 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    高熊果酚苷; 高熊果酚甙; Homoarbutin CFN90539 25712-94-1 C13H18O7 = 286.27 5mg QQ客服:1148253675
    4-甲氧基苯基β-D-吡喃葡萄糖苷; 4-Methoxyphenyl beta-D-glucopyranoside CFN90721 6032-32-2 C13H18O7 = 286.28 5mg QQ客服:215959384
    草夹竹桃苷; Androsin CFN93252 531-28-2 C15H20O8 = 328.3 10mg QQ客服:2159513211
    D-(-)-水杨苷; D-(-)-水杨甙; D-(-)-Salicin CFN99541 138-52-3 C13H18O7 = 286.27 20mg QQ客服:215959384
    牡丹酚新甙; Apiopaeonoside CFN90664 100291-86-9 C20H28O12 = 460.43 20mg QQ客服:2932563308
    丹皮酚原苷; Paeonolide CFN90668 72520-92-4 C20H28O12 = 460.43 20mg QQ客服:215959384
    二酚基水杨苷; 鄂西香茶菜苷; Henryoside CFN97203 72021-23-9 C26H32O15 = 584.5 5mg QQ客服:2932563308
    柳匍匐次苷; Salirepin CFN98314 26652-12-0 C13H18O8 = 302.3 5mg QQ客服:1148253675
    仙茅苷乙; Curculigoside B CFN92961 143601-09-6 C21H24O11 = 452.41 5mg QQ客服:215959384
    仙茅苷; Curculigoside CFN97419 85643-19-2 C22H26O11 = 466.4 20mg QQ客服:3257982914

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