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  • 柳杉二醇

    Cryptomeridiol

    柳杉二醇
    产品编号 CFN98698
    CAS编号 4666-84-6
    分子式 = 分子量 C15H28O2 = 240.4
    产品纯度 >=98%
    物理属性 Oil
    化合物类型 Sesquiterpenoids
    植物来源 The herbs of Blumea balsamifera DC
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    柳杉二醇 CFN98698 4666-84-6 1mg QQ客服:2056216494
    柳杉二醇 CFN98698 4666-84-6 5mg QQ客服:2056216494
    柳杉二醇 CFN98698 4666-84-6 10mg QQ客服:2056216494
    柳杉二醇 CFN98698 4666-84-6 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Auburn University (USA)
  • Osmania University (India)
  • Ateneo de Manila University (Philippines)
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
  • Universidad de Antioquia (Colombia)
  • University of Zurich (Switzerland)
  • Sant Gadge Baba Amravati University (India)
  • University of Otago (New Zealand)
  • Universitas Airlangga (Indonesia)
  • Universiti Kebangsaan Malaysia (Malaysia)
  • Chulalongkorn University (Thailand)
  • Complutense University of Madrid (Spain)
  • Vin?a Institute of Nuclear Sciences (Serbia)
  • University of Minnesota (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Pharmacol Res.2020, 161:105205.
  • Eur J Pharmacol.2021, 899:174010.
  • Biochem Biophys Res Commun.2018, 505(1):261-266
  • Evid Based Complement Alternat Med.2019, 2019:2135351
  • JAOCS2021, 98(7):779-794.
  • Pharmacol Rep.2022, 74(1):175-188.
  • Compounds.2023, 3(1), 169-179.
  • Chemistry of Plant Raw Materials2019, 4:135-147
  • Environ Toxicol.2019, 34(12):1354-1362
  • Processes2022, 10(10), 2008.
  • Separations2021, 8(6),80.
  • Molecules.2020, 25(21):5087.
  • Chem Biol Interact.2018, 290:44-51
  • Nutrients2020, 12(3):811.
  • J of the Korean Society of Cosmetics and Cosmetology2018, 399-406
  • Plos One.2020, 10.1371
  • Planta Med.2018, 84(15):1101-1109
  • J Chromatogr A.2017, 1518:46-58
  • Biomed Chromatogr.2016, 30(10):1573-81
  • Food and Agriculture Org. Of the UN2019, 151-160
  • Evid-Based Compl Alt2020, 7202519:13
  • RSC Adv.2018, 32621-32636
  • Kasetsart University2022, ethesis.1144.
  • ...
  • 生物活性
    Description: Cryptomeridiol is a potential skin-whitening agent, exhibits melanogenesis inhibitory activity on α-MSH-stimulated B16 melanoma cells. Cryptomeridiol has low activity against A. niger, T. mentagrophytes, and C. albicans. (-)-Cryptomeridiol also exhibits a significant and concentration-dependent inhibitory effect on PAF receptor binding, with inhibitory concentration (IC)(50) values of 17.5 uM.
    Targets: PAFR | Antifection
    In vitro:
    Chem Biodivers. 2012 Aug;9(8):1500-7.
    Melanogenesis inhibitory activity of sesquiterpenes from Canarium ovatum resin in mouse B16 melanoma cells.Melanogenesis inhibitory activity of sesquiterpenes from Canarium ovatum resin in mouse B16 melanoma cells.[Pubmed: 22899610]

    METHODS AND RESULTS:
    Cryptomeridiol (1), 4-epiCryptomeridiol (2), and cadin-1(14)-ene-7α,11-diol (4), exhibited inhibitory effects with 27.4-34.1 and 39.0-56.9% reduction of melanin content at 50 and 100 μM, respectively, with no or very low toxicity to the cells (80.9-103.9% of cell viability at 100 μM). Western-blot analysis revealed that Cryptomeridiol and 4-epiCryptomeridiolreduced the protein levels of MITF (=microphtalmia-associated transcription factor), tyrosinase, and TRP-2 (=tyrosine-related protein 2), mostly in a concentration-dependent manner, suggesting that these compounds exhibit melanogenesis inhibitory activity on α-MSH-stimulated B16 melanoma cells by, at least in part, inhibiting the expression of MITF, followed by decreasing the expression of tyrosinase and TRP-2.
    CONCLUSIONS:
    Three sesquiterpene alcohols, i.e., Cryptomeridiol, 4-epiCryptomeridiol, and 4, are, therefore, considered to be valuable as potential skin-whitening agents.
    Phytother Res. 2012 May;26(5):687-91.
    Inhibitory effect of compounds from Goniothalamus tapis Miq. and Goniothalamus uvaroides King on platelet-activating factor receptor binding.[Pubmed: 22002630]
    Phytochemical investigation on the bark of Goniothalamus tapis Miq. and G. uvaroides King has resulted in the isolation of eight styryl-lactones, (-)-Cryptomeridiol, liriodenine, 3-methyl-1H-benz[f]indole-4,9-dione, (-)-stigmasterol and dimethyl terephthalate.
    METHODS AND RESULTS:
    The structures of the compounds were elucidated by spectroscopic techniques. The compounds were evaluated for their effect on platelet-activating factor (PAF) receptor binding on rabbit platelets using (3) H-PAF as a ligand.
    CONCLUSIONS:
    Among the compounds tested, (-)-Cryptomeridiol, (+)-goniothalamin and (+)-isoaltholactone exhibited a significant and concentration-dependent inhibitory effect on PAF receptor binding, with inhibitory concentration (IC)(50) values of 17.5, 19.7 and 46.5 µm, respectively. The inhibitory effects of the first two compounds were comparable to that obtained from the positive control, cedrol.
    Nat Prod Res. 2005 Apr;19(3):231-7.
    Antifungal metabolites from Blumea balsamifera.[Pubmed: 15702636]

    METHODS AND RESULTS:
    The leaves of Blumea balsamifera afforded icthyothereol acetate, cryptomeridiol, lutein, and beta-carotene. The structures of icthyothereol acetate (1) and cryptomeridiol (2) were elucidated by extensive 1D and 2D NMR spectroscopy, while those of lutein and beta-carotene were identified by comparison with literature data. Antimicrobial tests indicated that 1 has moderate activity against the fungi Aspergillus niger, Trichophyton mentagrophytes, and Candida albicans, while 2 has low activity against A. niger, T. mentagrophytes, and C. albicans.
    CONCLUSIONS:
    Both compounds have no antimicrobial activity against Psuedomonas aeruginosa, Staphylococcus aureus, Bacillus subtilis, and Escherichia coli.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.1597 mL 20.7987 mL 41.5973 mL 83.1947 mL 103.9933 mL
    5 mM 0.8319 mL 4.1597 mL 8.3195 mL 16.6389 mL 20.7987 mL
    10 mM 0.416 mL 2.0799 mL 4.1597 mL 8.3195 mL 10.3993 mL
    50 mM 0.0832 mL 0.416 mL 0.8319 mL 1.6639 mL 2.0799 mL
    100 mM 0.0416 mL 0.208 mL 0.416 mL 0.8319 mL 1.0399 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    橐吾香附酮醇; Ligucyperonol CFN96346 105108-20-1 C15H22O2 = 234.3 5mg QQ客服:2159513211
    Canusesnol A; Canusesnol A CFN97296 816456-90-3 C15H22O3 = 250.3 5mg QQ客服:1457312923
    Eudesma-3,11-dien-2-one; Eudesma-3,11-dien-2-one CFN89327 86917-79-5 C15H22O = 218.34 5mg QQ客服:3257982914
    beta-莎草醇; Beta-Rotunol CFN96335 24405-57-0 C15H22O2 = 234.3 5mg QQ客服:2056216494
    1beta,6alpha-二羟基-4(14)-桉叶烯; Voleneol CFN97192 70389-88-7 C15H26O2 = 238.4 5mg QQ客服:1457312923
    beta-桉叶醇; beta-Eudesmol CFN99537 473-15-4 C15H26O = 222.37 20mg QQ客服:1413575084
    (2R,4aR,5R,8aS)-十氢-5-羟基-alpha,alpha,4a-三甲基-8-亚甲基-2-萘甲醇 ; 1beta-Hydroxy-beta-eudesmol CFN96795 83217-89-4 C15H26O2 = 238.37 5mg QQ客服:2056216494
    Eudesm-4(15)-ene-3alpha,11-diol; Eudesm-4(15)-ene-3alpha,11-diol CFN96161 113773-90-3 C15H26O2 = 238.4 5mg QQ客服:1413575084
    (4aS-顺式)-4,4a,5,6,7,8-六氢-8-羟基-4a,8-二甲基-2(3H)-萘酮; 4-Hydroxy-11,12,13-trinor-5-eudesmen-7-one CFN96334 133369-42-3 C12H18O2 = 194.3 5mg QQ客服:215959384
    Oxyphyllenone A; Oxyphyllenone A CFN96801 363610-34-8 C12H18O3 = 210.27 5mg QQ客服:215959384

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