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  • 西红花苷II

    Crocin II

    西红花苷II
    产品编号 CFN99928
    CAS编号 55750-84-0
    分子式 = 分子量 C38H54O19 = 814.83
    产品纯度 >=98%
    物理属性 Dark red powder
    化合物类型 Diterpenoids
    植物来源 The stigma of Crocus sativus L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    西红花苷II CFN99928 55750-84-0 10mg QQ客服:215959384
    西红花苷II CFN99928 55750-84-0 20mg QQ客服:215959384
    西红花苷II CFN99928 55750-84-0 50mg QQ客服:215959384
    西红花苷II CFN99928 55750-84-0 100mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Illinois (USA)
  • Guangzhou Institutes of Biomedicine and Health (China)
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  • Yale University (USA)
  • University of Padjajaran (Indonesia)
  • Nanjing University of Chinese Medicine (China)
  • University of Wuerzburg (Germany)
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  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Food Chem.2019, 275:746-753
  • J Korean Med Ophthalmol Otolaryngol Dermatol2023, 36(1):1-20.
  • J Pharm Biomed Anal.2021, 196:113931.
  • Current Pharmaceutical Analysis2017, 13(5)
  • Molecules.2018, 23(2)
  • Plants (Basel).2021, 10(11):2525.
  • Cell Rep.2022, 39(1):110643.
  • Biomol Ther (Seoul).2023, 31(1):40-47.
  • Foods.2022, 11(12):1773.
  • Separations2021, 8(1), 1.
  • Biomed Pharmacother.2023, 166:115329.
  • Anticancer Res.2020, 40(10):5529-5538.
  • Pharmacognosy Magazine2017, 13(52):868-874
  • Int Immunopharmacol.2023, 7:127:111322.
  • J Chromatogr B Analyt Technol Biomed Life Sci. 2017, 1064:115-123
  • J Immunol.2023, ji2200727.
  • J Herbmed Pharmacol.2018, 7(4):280-286
  • Molecules.2021, 26(19):6032.
  • J Nat Med.2017, 71(2):457-462
  • Foods.2021, 10(6):1378.
  • Neurochem Int.2018, 121:114-124
  • JAOCS2021, 98(7):779-794.
  • Nutrients.2023, 15(13):2960.
  • ...
  • 生物活性
    Description: Crocin has antihyperlipidemic, antidepressant , anti-inflammatory and anti-apoptotic effects. It can reduce the protein expression of iNOS and caspase-3, and increase CREB, BDNF and VGF levels in hippocampus.
    Targets: NOS | Caspase
    In vivo:
    Braz.J.Pharm.Sci., 2015, 51(3):637-642
    A preliminary study of the anti-inflammatory and anti-apoptotic effects of crocin against gastric ischemia-reperfusion injury in rats[Reference: WebLink]
    The aim of the present study was to investigate the protective effect of crocin on gastric mucosal lesions caused by ischemia-reperfusion (I/R) injury in rats.
    METHODS AND RESULTS:
    Thirty-two male rats were randomly divided into sham, I/R, I/R + crocin pretreatment and crocin alone groups. To induce I/R lesions, the celiac artery was clamped for 30 min, and the clamp was then removed to allow reperfusion for 3 h. Crocin-pretreated rats received crocin (15 mg/kg, i.p.) 30 min prior to the induction of I/R injury. Samples of gastric mucosa were collected to quantify the protein expression of caspase-3, an apoptotic factor, and inducible nitric oxide synthase (iNOS), a pro-inflammatory protein, by Western blot. Pretreatment with crocin decreased the total area of gastric lesions and decreased the protein expression levels of caspase-3 and iNOS induced by I/R injury.
    CONCLUSIONS:
    Our findings showed a protective effect of crocin in gastric mucosa against I/R injury. This effect of crocin was mainly mediated by reducing the protein expression of iNOS and caspase-3.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.2272 mL 6.1362 mL 12.2725 mL 24.545 mL 30.6812 mL
    5 mM 0.2454 mL 1.2272 mL 2.4545 mL 4.909 mL 6.1362 mL
    10 mM 0.1227 mL 0.6136 mL 1.2272 mL 2.4545 mL 3.0681 mL
    50 mM 0.0245 mL 0.1227 mL 0.2454 mL 0.4909 mL 0.6136 mL
    100 mM 0.0123 mL 0.0614 mL 0.1227 mL 0.2454 mL 0.3068 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    植酮; Phytone CFN97734 502-69-2 C18H36O = 268.48 20mg QQ客服:1457312923
    植物醇; Phytol CFN99630 150-86-7 C20H40O = 296.5 20mg QQ客服:3257982914
    藏红花酸; Croceic acid CFN90226 27876-94-4 C20H24O4 = 328.40 20mg QQ客服:3257982914
    Nemoralisin; Nemoralisin CFN97516 942480-13-9 C20H28O4 = 332.4 5mg QQ客服:215959384
    维生素A酸; 视黄酸; Retinoic acid CFN90026 302-79-4 C20H28O2 = 300.44 20mg QQ客服:1413575084
    阿维A; Acitretin CFN93053 55079-83-9 C21H26O3 = 326.43 5mg QQ客服:2056216494
    西红花苷I; Crocin I CFN99927 94238-00-3 C44H64O24 = 976.96 20mg QQ客服:2056216494
    西红花苷II; Crocin II CFN99928 55750-84-0 C38H54O19 = 814.83 20mg QQ客服:2159513211
    降红木素; Bixin CFN91597 6983-79-5 C25H30O4 = 394.5 5mg QQ客服:2159513211

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